The Economic Impact of Blindness in Europe

Chakravarthy, Usha; Biundo, Eliana; Saka, Rasit Omer; Fasser, Christina; Bourne, Rupert; Little, Julie‐Anne

doi:10.1080/09286586.2017.1281426

Cited by 50 publications

(41 citation statements)

References 18 publications

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“…Vision loss owing to photoreceptor degeneration is a devastating handicap with far-reaching effects on the quality-of-life of the affected individuals and on society as a whole [2]. Photoreceptor degeneration occurs in etiologically different diseases, with important causes being diabetic retinopathy [3], age-related macular degeneration (AMD) [4] and hereditary retinal degeneration [5].…”

Section: The Retina and Photoreceptor Degenerationmentioning

confidence: 99%

Drug delivery to retinal photoreceptors

Himawan¹,

Ekström

Buzgo³

et al. 2019

Drug Discovery Today

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Section: The Retina and Photoreceptor Degenerationmentioning

confidence: 99%

Drug delivery to retinal photoreceptors

Himawan¹,

Ekström

Buzgo³

et al. 2019

Drug Discovery Today

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“…Owing to an increase in the number of Spanish adults with obesity, 1,17 a relatively high prevalence of poor ocular health, 15,16,[18][19][20][21] an important economic burden associated with eye diseases, 22 and the fact that no studies have been carried out on associations between obesity and ocular health in this country, it is important to investigate these potential relationships in Spain. Thus, the present study aims to investigate associations between obesity and cataract, wearing glasses or contact lenses, and trouble seeing in a large representative sample of the Spanish adult population.…”

Section: Introductionmentioning

confidence: 99%

Associations between obesity and ocular health in Spanish adults

et al. 2020

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Introduction: Obesity has been associated with poor vascular health, but not in a Spanish population. Therefore, the study aimed to investigate associations between obesity and cataract, wearing glasses or contact lenses, and trouble seeing in a large representative sample of the Spanish adult population. Methods: Cross-sectional data from the Spanish National Health Survey 2017 were analyzed. Body mass index (BMI) was calculated and obesity was defined as BMI ≥ 30 kg/m 2. Ocular health included three dichotomous variables (presence vs absence): self-reported cataract, wearing glasses or contact lenses, and trouble seeing. Multivariable logistic regressions were used to assess associations between obesity (independent variable) and ocular health outcomes (dependent variables). Covariates included in the analysis were sex, age, marital status, education, smoking, alcohol, and diabetes. Results: A total of 23 089 participants were included (54.1% female; mean [SD] age = 53.4 [18.9] years). After adjusting for sex, age, marital status, education, smoking, alcohol, diabetes, and wearing glasses or contact lenses (for the trouble seeing analysis only), obesity was found to be a risk factor for cataract (odds ratio [OR] = 1.22; 95% confidence interval [CI], 1.09-1.37) and trouble seeing (OR = 1.20; 95% CI, 1.09-1.32) but not for wearing glasses or contact lenses (OR = 0.99; 95% CI, 0.91-1.08). These findings were corroborated in participants ≥64 years. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…The reduced independence associated with blindness, leading to social isolation, unemployment, and depression, ranks it among the major health concerns, on a level with cancer and Alzheimer's (1). In addition to the personal impact of visual disability, the economic burden on health and social systems is significant (2).…”

mentioning

confidence: 99%

The primate model for understanding and restoring vision

Picaud

Dalkara

Marazova

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

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Retinal degenerative diseases caused by photoreceptor cell death are major causes of irreversible vision loss. As only primates have a macula, the nonhuman primate (NHP) models have a crucial role not only in revealing biological mechanisms underlying high-acuity vision but also in the development of therapies. Successful translation of basic research findings into clinical trials and, moreover, approval of the first therapies for blinding inherited and age-related retinal dystrophies has been reported in recent years. This article explores the value of the NHP models in understanding human vision and reviews their contribution to the development of innovative therapeutic strategies to save and restore vision.

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The Economic Impact of Blindness in Europe

Abstract: The cost of blindness and MSVI in the EU is substantial. Wider use of available cost-effective treatment and prevention strategies may reduce the burden significantly.

Cited by 50 publications

References 18 publications

Drug delivery to retinal photoreceptors

Drug delivery to retinal photoreceptors

Associations between obesity and ocular health in Spanish adults

The primate model for understanding and restoring vision

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