The economic feasibility of various treatment combinations of rice (Oryza sativa L.)

Singh, Shashank Shekher; Singh, Permendra; Singh, Ashutosh; Singh, Anil Kumar

doi:10.22271/chemi.2021.v9.i2d.11813

Cited by 2 publications

(3 citation statements)

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“…Also, the IR spectrum displays the appearance of new bands at 554 and 473 cm −1 . This indicates the coordination of the azomethine nitrogen and the (OH) salicylaldehyde moiety of the ligand with Sn (ph) 2 (IV) ion after its deprotonation 65 . v (SnC) binding was observed at 632 cm −1 65 .…”

Section: Resultsmentioning

confidence: 96%

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Synthesis, anticancer, anti‐inflammatory, antimicrobial activities, molecular docking, and Density functional theory studies of nanometal (IV) glycoconjugates

Al Motwaa,

Al‐Otaibi,

Abubakr

et al. 2024

Applied Organom Chemis

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Oxovanadium (IV) and diphenyltin (IV) complexes were synthesized on the nanoscale based on the Schiff base (H2L) derived from salicylaldehyde and d‐glucosamine. The complexes were formed with a molar ratio of 1:1 and 1:2 (metal: dligand) relative to oxovanadium (IV) and diphenyltin (IV), respectively. Fourier‐transform infrared spectroscopy, 1H and 13C nuclear magnetic resonance, mass fragmentations, electronic transitions, thermogravimetric analysis, and density functional theory were employed to validate the structure of synthesized compounds. The results demonstrated that the ligand (H2L) was successfully attached to oxovanadium (IV) and diphenyltin (IV) as di‐anionic and mono‐anionic ligands, respectively. The size of the complexes was investigated using the transmission scanning microscope. The work presents a prospective concept for the drug design of the targeted anticancer through the glucose moiety. All compounds revealed remarkable anticancer activities against the colorectal (HCT‐116) cell line, recording IC50 values 4.94, 21.73, and 62.5 μg/ml for VO (II)(L), free H2L, and Sn (ph)2(HL)2, respectively. The IC50 value of VO (II)(L) complex was increased after the quercetin inhibitor. Therefore, the sugar‐conjugated compound can be recognized by the glucose recognition binding site of GLUT and their cell‐killing effect depends highly on the GLUT inhibitor, quercetin. The potential GLUT transportability of the compounds was investigated through a molecular docking study. The anti‐migration activity was investigated for VO (II)(L) complex. The free ligand observed the best antimicrobial results. The antibacterial stimulation was investigated and represented different interaction types with the selected ribosyl transferase enzyme.

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Section: Resultsmentioning

confidence: 96%

“…This indicates the coordination of the azomethine nitrogen and the (OH) salicylaldehyde moiety of the ligand with Sn (ph) 2 (IV) ion after its deprotonation 65 . v (SnC) binding was observed at 632 cm −1 65 . (Figures S1–S3) represent the spectra of all compounds.…”

Section: Resultsmentioning

confidence: 96%

Synthesis, anticancer, anti‐inflammatory, antimicrobial activities, molecular docking, and Density functional theory studies of nanometal (IV) glycoconjugates

Al Motwaa,

Al‐Otaibi,

Abubakr

et al. 2024

Applied Organom Chemis

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“…In a previous study, the same observation was made where the melting points of Cu(II)‐Ln(III) containing mixed metal complexes had higher melting points than the mononuclear Cu(II) complex. [ 19 ] The decomposition temperatures and melting points were high due to the predicted neutral nature of the complexes.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, computational drug likeness, DFT studies and in vitro biological activity evaluation of some heteronuclear complexes of functionalized (E)‐2‐(butan‐2‐ylidene) hydrazinecarbothioamide ligand

Khan,

Azad,

Ahmad

et al. 2023

Vietnam Journal of Chemistry

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The dinuclear complexes of Schiff bases possess interesting structures and activity spectrum. Five mixed metal complexes of 2‐butanone thiosemicarbazone were prepared and characterized by different spectroscopic techniques. Molecular docking studies were done with the selected proteins. Computational drug likeness prediction was done using automated softwares. Toxicity assessment and Principal Component Analysis (PCA) was done by OSIRIS 4.6.1 and used to assess the toxicity whereas bioactivity scores and physicochemical properties were predicted by Molinspiration 2016.03. Principal Component Analysis (PCA) was performed using Osiris Property Explorer 4.5.1. Molecular docking studies were performed with three proteins. The anticancer activity was tested against MCF‐7, A549 and HepG‐2 cell lines whereas antibacterial activity was tested against two bacterial strains. The melting points of the complexes were >350oC, indicating high thermal stability. Cu‐Zn‐containing complex showed the least binding energy against the three proteins. The bioactivity scores of the complexes were between ‐0.50 and 0.0. Against A549 Cu‐Zn, Co‐Zn and Fe‐Zn containing complexes showed potential activity. Against MCF‐7, Fe‐Cu containing complex had IC50 of 53.5 whereas Co‐Zn containing complex was active against HepG2. Three complexes were active against S. aureus in the tested range. The dinuclear complexes showed potential biological activity as compared to the mononuclear complexes.

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The economic feasibility of various treatment combinations of rice (Oryza sativa L.)

Cited by 2 publications

References 0 publications

Synthesis, anticancer, anti‐inflammatory, antimicrobial activities, molecular docking, and Density functional theory studies of nanometal (IV) glycoconjugates

Synthesis, anticancer, anti‐inflammatory, antimicrobial activities, molecular docking, and Density functional theory studies of nanometal (IV) glycoconjugates

Synthesis, computational drug likeness, DFT studies and in vitro biological activity evaluation of some heteronuclear complexes of functionalized (E)‐2‐(butan‐2‐ylidene) hydrazinecarbothioamide ligand

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