The ecology of extended-spectrum β-lactamases (ESBLs) in the developed world

Doi, Yohei; Iovleva, Alina; Bonomo, Robert A.

doi:10.1093/jtm/taw102

Cited by 199 publications

(175 citation statements)

References 71 publications

(70 reference statements)

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“…The main mechanisms of resistance to cefotaxime are ESBLs. Different ESBLs have been described to date, with the main types being TEM-type, SHV-type, and CTX-Mtype, with the CTX-M-type being the most currently extended ESBL at a global level (25)(26)(27)(28). Travelers have been shown to be potential carriers of the ESBL-producing Enterobacteriaceae in the intestinal tract, facilitating the dissemination of these microorganisms between countries (8, 28-33).…”

Section: Discussionmentioning

confidence: 99%

Emergence of Resistance to Quinolones and β-Lactam Antibiotics in Enteroaggregative and Enterotoxigenic Escherichia coli Causing Traveler’s Diarrhea

Guiral

Quiles

Muñoz

et al. 2019

Antimicrob Agents Chemother

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The objective of this study was to assess the antimicrobial resistance of enteroaggregative Escherichia coli (EAEC) and enterotoxigenic E. coli (ETEC) strains causing traveler’s diarrhea (TD) and to investigate the molecular characterization of antimicrobial resistance genes to third-generation cephalosporins, cephamycins, and quinolones. Overall, 39 EAEC and 43 ETEC clinical isolates were studied. The susceptibilities of EAEC and ETEC against ampicillin, amoxicillin-clavulanic acid, cefotaxime, imipenem, chloramphenicol, tetracycline, co-trimoxazole, nalidixic acid, ciprofloxacin, azithromycin, and rifaximin were determined. All genes encoding resistance determinants were detected by PCR or PCR plus DNA sequencing. The epidemiology of selected EAEC and ETEC strains was studied using multilocus sequence typing (MLST). The resistance to quinolones of EAEC and ETEC strains causing TD has significantly increased over the last decades, and high percentages have been found especially in patients traveling to India and sub-Saharan Africa. Sequence type 38 (ST38) and ST131, carrying the blaCTX-M-15 and blaCTX-M-27 genes, respectively, are highly prevalent among extended-spectrum β-lactamase (ESBL)-producing EAEC and ETEC strains. The cephamycinase ACT-20 is described in the present study for the first time in EAEC and ETEC strains causing TD in patients who had traveled to Central America. The percentages of resistance to azithromycin in EAEC and ETEC isolates from patients to Southeast Asia/India and Africa are above 25%. Meanwhile, rifaximin is still active against EAEC and ETEC, with the prevalence of resistant strains not being high. In conclusion, fluoroquinolones should no longer be considered the drugs of choice for the prevention or treatment in TD for travelers traveling to India and Africa. Azithromycin and rifaximin are still a good alternative to treat TD caused by EAEC or ETEC.

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Section: Discussionmentioning

confidence: 99%

Emergence of Resistance to Quinolones and β-Lactam Antibiotics in Enteroaggregative and Enterotoxigenic Escherichia coli Causing Traveler’s Diarrhea

Guiral

Quiles

Muñoz

et al. 2019

Antimicrob Agents Chemother

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“…The CRE and NDM-producing plasmids in retail meat might originate from livestock and endanger public health via direct contact, the food chain, and the environment. It is likely that bla NDM-5 -carrying IncX3 might further spread via international travel and trade, as observed in extendedspectrum ␤-lactamase (ESBL)-producing Enterobacteriaceae (21). From the one health perspective, more extensive surveillance and development of multisectoral strategies to control its dissemination are urgently needed.…”

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confidence: 99%

Rapid Increase in Carbapenemase-Producing Enterobacteriaceae in Retail Meat Driven by the Spread of the bla _NDM-5 -Carrying IncX3 Plasmid in China from 2016 to 2018

Zhang

Huang

et al. 2019

Antimicrob Agents Chemother

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The presence and molecular characteristics of carbapenemase-producing Enterobacteriaceae (CPE) among meat products in China were investigated. A total of 110 carbapenem-resistant Enterobacteriaceae (CRE) isolates, including 94 Escherichia coli and 10 Klebsiella pneumoniae isolates, were identified from 105 of 794 (13.2%) samples. The positive rates markedly increased from 2016 (9.4%) to 2018 (22.2%). Only bla NDM genes were detected; 79.1% of bla NDM genes were carried by IncX3 plasmids. Routine monitoring of carbapenemase-producing Enterobacteriaceae in the animal food supply is highly recommended.

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“…As increased usage of carbapenems to treat ESBL-producing pathogens has helped drive carbapenem resistance, "carbapenem-sparing" therapeutic options are required to stem resistance development and dissemination among Gram-negative pathogens (2,32,33). Development of the combination of cefepime with the novel BLI enmetazobactam aims to provide empiric and definitive therapy for infections caused by Enterobacteriaceae, particularly those expressing ESBLs.…”

Section: Discussionmentioning

confidence: 99%

Development of Broth Microdilution MIC and Disk Diffusion Antimicrobial Susceptibility Test Quality Control Ranges for the Combination of Cefepime and the Novel β-Lactamase Inhibitor Enmetazobactam

Belley¹,

Huband

Fedler

et al. 2019

J Clin Microbiol

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Third-generation cephalosporin resistance among Enterobacteriaceae, mediated by the spread of extended-spectrum ␤-lactamases (ESBLs), is a very serious medical concern with limited therapeutic options. Enmetazobactam (formerly AAI101) is a novel penicillanic sulfone ␤-lactamase inhibitor active against a wide range of ESBLs. The combination of enmetazobactam and cefepime has entered phase 3 development in patients with complicated urinary tract infections. Using the Clinical and Laboratory Standards Institute (CLSI) M23 tier 2 study design, broth microdilution MIC and disk diffusion quality control (QC) ranges were determined for cefepime-enmetazobactam. Enmetazobactam was tested at a fixed concentration of 8 g/ml in the MIC assay, and a cefepime-enmetazobactam disk mass of 30/20 g was used in the disk diffusion assay. Escherichia coli ATCC 25922, E. coli ATCC 35218, E. coli NCTC 13353, Klebsiella pneumoniae ATCC 700603, and Pseudomonas aeruginosa ATCC 27853 were chosen as reference strains. The CTX-M-15-producing E. coli NCTC 13353 isolate is recommended for routine testing to control for inhibition of ESBL activity by enmetazobactam. Broth microdilution MIC QC ranges spanned 3 to 4 doubling dilutions and contained 99.6% to 100.0% of obtained MIC values for the five reference strains. Disk diffusion yielded inhibition zone diameter QC ranges that spanned 7 mm and encompassed 97.1% to 100.0% of the obtained values. Quality control ranges were approved by the CLSI in 2017 (broth microdilution MIC) and 2019 (disk diffusion). The established QC ranges will ensure that appropriate assay performance criteria are attained using CLSI reference methodology when determining the susceptibility of clinical isolates to cefepime-enmetazobactam.

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The ecology of extended-spectrum β-lactamases (ESBLs) in the developed world

Abstract: ESBL-producing Enterobacteriaceae has become a major multidrug-resistant pathogen in the last two decades, especially in the community settings. The multifactorial nature of its expansion poses a major challenge in the efforts to control them.

Cited by 199 publications

References 71 publications

Emergence of Resistance to Quinolones and β-Lactam Antibiotics in Enteroaggregative and Enterotoxigenic Escherichia coli Causing Traveler’s Diarrhea

Emergence of Resistance to Quinolones and β-Lactam Antibiotics in Enteroaggregative and Enterotoxigenic Escherichia coli Causing Traveler’s Diarrhea

Rapid Increase in Carbapenemase-Producing Enterobacteriaceae in Retail Meat Driven by the Spread of the bla _NDM-5 -Carrying IncX3 Plasmid in China from 2016 to 2018

Development of Broth Microdilution MIC and Disk Diffusion Antimicrobial Susceptibility Test Quality Control Ranges for the Combination of Cefepime and the Novel β-Lactamase Inhibitor Enmetazobactam

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The ecology of extended-spectrum β-lactamases (ESBLs) in the developed world

Abstract: ESBL-producing Enterobacteriaceae has become a major multidrug-resistant pathogen in the last two decades, especially in the community settings. The multifactorial nature of its expansion poses a major challenge in the efforts to control them.

Cited by 199 publications

References 71 publications

Emergence of Resistance to Quinolones and β-Lactam Antibiotics in Enteroaggregative and Enterotoxigenic Escherichia coli Causing Traveler’s Diarrhea

Emergence of Resistance to Quinolones and β-Lactam Antibiotics in Enteroaggregative and Enterotoxigenic Escherichia coli Causing Traveler’s Diarrhea

Rapid Increase in Carbapenemase-Producing Enterobacteriaceae in Retail Meat Driven by the Spread of the bla NDM-5 -Carrying IncX3 Plasmid in China from 2016 to 2018

Development of Broth Microdilution MIC and Disk Diffusion Antimicrobial Susceptibility Test Quality Control Ranges for the Combination of Cefepime and the Novel β-Lactamase Inhibitor Enmetazobactam

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Product

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Rapid Increase in Carbapenemase-Producing Enterobacteriaceae in Retail Meat Driven by the Spread of the bla _NDM-5 -Carrying IncX3 Plasmid in China from 2016 to 2018