The Eccrine Sweat Glands of Patients in Uremia

Cawley, Edward P.

doi:10.1001/archderm.1961.01580180005001

Cited by 41 publications

(18 citation statements)

References 9 publications

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“…[210–12] Eighteen (64.26%) of our xerotic patients were known cases of diabetes mellitus and the ichthyosis involved large areas of the body as compared to other CRF patients. The pathogenesis of xerosis is unknown; various causes implicated include reduced sweat[13] secondary to high dose diuretic regimens used to treat CRF, elevated plasma vitamin A, elevated retinol binding protein,[14] alkalinity of skin,[15] and protein-calorie malnutrition[16] owing to dietary restrictions. The therapy remains nonspecific and challenging.…”

Section: Discussionmentioning

confidence: 99%

Clinicoepidemiological study of skin manifestations in patients of chronic renal failure on hemodialysis

Deshmukh

Dash

Chaudhari

et al. 2013

Indian Dermatol Online J

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Background:Chronic renal failure (CRF) is associated with a variety of cutaneous manifestations as a result of underlying etiology as well as the various treatment modalities.Aim:To evaluate the prevalence of various dermatoses in patients with CRF on hemodialysis and to study the effect of hemodialysis on the intensity of pruritus.Materials and Methods:A total of 35 patients of CRF on hemodialysis having at least one cutaneous manifestation were included in the study.Results:Twenty-four (68.71%) cases in our study belonged to the age group of 50-69 years, out of which 16 cases were in the sixth decade. Xerosis and pruritus occurred in 80% and 65.71% of cases, respectively. Other common findings included pallor (68.57%), dyspigmentation (34.29%), cutaneous infections (34.39%), acquired perforating dermatosis (17.4%), and nail changes (60%). Hemodialysis failed to improve pruritus in 17 (73.9%) of our patients. Twenty-six patients (74.28%) suffered from hypertension, 13 of them also were known cases of type II diabetes mellitus. Five patients suffered exclusively from type II diabetes mellitus.Conclusions:In our small study, xerosis was the commonest finding and pruritus, the commonest symptom. The intensity of pruritus was largely unaffected by hemodialysis.

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Section: Discussionmentioning

confidence: 99%

Clinicoepidemiological study of skin manifestations in patients of chronic renal failure on hemodialysis

Deshmukh

Dash

Chaudhari

et al. 2013

Indian Dermatol Online J

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“…Xerosis and follicular hyperkeratosis are among the most commonly noted lesions in uremic patients (5,19). These disorders have multifactorial causes that are still largely unknown, but may be related to decreased function of the eccrine sweat glands (20) or to modifications of vitamin A use at the cellular level (2i). Both conditions are quite frequent in children.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous and Oral Lesions in 32 Children After Renal Transplantation

Menni

Beretta

Piccinno

et al. 1991

Pediatric Dermatology

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A variety of skin and oral mucosal lesions appearing in patients after renal transplantation have been reported in the literature. Because most of these data pertain to adults, we studied a group of children with kidney transplants to investigate the occurrence of skin and/or oral mucosal lesions, compare them with those observed in adults, and contribute to the knowledge of the pathogenesis of these disorders. Our series consisted of 32 patients aged 5 to 18 years, all of whom had skin and/or oral mucosal lesions that were classified as being either drug induced, probably related to uremia, or due to other causes. A possible relationship between drug-induced lesions and the therapeutic immunosuppressive regimen in use was investigated. In addition, two formerly unreported lesions were seen in these patients: hypertrophy of lingual fungiform papillae and onychoschizia. The former occurred only in children receiving cyclosporine. Compared with adults, the frequency of gingival hypertrophy was higher and that of infectious disease was lower.

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“…Its prevalence was similar in patients on RHT (66%) and in those on CAPD (75%). The causes of this disorder are largely unknown, but it is possible that it may be referred to an impairment of eccrine sweat gland function [10]. Another possible cause of cutaneous xerosis could be an alteration of vitamin A metabolism.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Abnormalities in Uremic Patients

Bencini¹,

Montagnino

Citterio

et al. 1985

Nephron

136

107

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94 uremic patients, 68 on regular hemodialysis treatment (RHT) and 26 on chronic ambulatory peritoneal dialysis (CAPD), were followed for up to 20 months in search of dermatological manifestations. 79% of RHT and 76% of CAPD patients had some kind of cutaneous lesion. The most characteristic features of cutaneous involvement in RHT and CAPD patients were: cutaneous xerosis, pruritus, infectious manifestations and disorders of pigmentation. In 4 RHT patients, precancerous and cancerous manifestations were also observed.

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The Eccrine Sweat Glands of Patients in Uremia

Cited by 41 publications

References 9 publications

Clinicoepidemiological study of skin manifestations in patients of chronic renal failure on hemodialysis

Clinicoepidemiological study of skin manifestations in patients of chronic renal failure on hemodialysis

Cutaneous and Oral Lesions in 32 Children After Renal Transplantation

Cutaneous Abnormalities in Uremic Patients

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