The ECAT HRRT: performance and first clinical application of the new high resolution research tomograph

Wienhard, K.; Schmand, M.; Casey, Michael; Baker, K.; Bao, Jun; Eriksson, Lars; Jones, W. Jeremy; Knoess, C.; Lenox, M.; Lercher, Martin J.; Luk, P.; Michel, Christian; Reed, Julie; Richerzhagen, N.; Treffert, J.; Vollmar, Stefan; Young, John W.; Heiss, Wolf‐Dieter; Nutt, R.

doi:10.1109/tns.2002.998689

Cited by 373 publications

(204 citation statements)

References 13 publications

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“…As mentioned previously, in case of the generally used NAW-OSEM algorithm, the spatial resolution of HR + is approximately 4.1 to 7.8 mm FWHM in 3D mode (Brix et al, 1997b). When using the PVC-NAW-OSEM algorithm on the same scanner, however, the resolution appears to be similar to the resolution obtained with standard OP-OSEM reconstructions on the HRRT (Figure 1), which is approximately 2.3 to 3.4 mm FWHM (de Jong et al, 2007;Wienhard et al, 2002). Interestingly, this large improvement in spatial resolution was not visible for the PVC-reconstructed HRRT data.…”

Section: Phantom Studysupporting

confidence: 55%

“…To this end, normal subjects were subjected to repeat [ 11 C]flumazenil scans on two different scanners with different spatial resolutions, and acquired data were reconstructed with and without PVC. A dedicated high-resolution PET scanner (Wienhard et al, 2002) was used as a gold standard to validate PVC for standard (low-resolution) clinical PET scanners.…”

Section: Introductionmentioning

confidence: 99%

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In vivo Validation of Reconstruction-Based Resolution Recovery for Human Brain Studies

Mourik

Lubberink

Velden

et al. 2009

J Cereb Blood Flow Metab

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The aim of this study was to validate in vivo the accuracy of a reconstruction-based partial volume correction (PVC), which takes into account the point spread function of the imaging system. The NEMA NU2 Image Quality phantom and five healthy volunteers (using [ 11 C]flumazenil) were scanned on both HR + and high-resolution research tomograph (HRRT) scanners. HR + data were reconstructed using normalization and attenuation-weighted ordered subsets expectation maximization (NAW-OSEM) and a PVC algorithm (PVC-NAW-OSEM). HRRT data were reconstructed using 3D ordinary Poisson OSEM (OP-OSEM) and a PVC algorithm (PVC-OP-OSEM). For clinical studies, parametric volume of distribution (V T ) images were generated. For phantom data, good recovery was found for both OP-OSEM (0.84 to 0.97) and PVC-OP-OSEM (0.91 to 0.98) HRRT reconstructions. In addition, for the HR + , good recovery was found for PVC-NAW-OSEM (0.84 to 0.94), corresponding well with OP-OSEM. Finally, for clinical data, good correspondence was found between PVC-NAW-OSEM and OP-OSEM-derived V T values (slope: 1.02 ± 0.08). This study showed that HR + image resolution using PVC-NAW-OSEM was comparable to that of the HRRT scanner. As the HRRT has a higher intrinsic resolution, this agreement validates reconstruction-based PVC as a means of improving the spatial resolution of the HR + scanner and thereby improving the quantitative accuracy of positron emission tomography.

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Section: Phantom Studysupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

In vivo Validation of Reconstruction-Based Resolution Recovery for Human Brain Studies

Mourik

Lubberink

Velden

et al. 2009

J Cereb Blood Flow Metab

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“…Although most attempts toward organ-specific imaging were based on stand-alone PET or SPECT systems [100][101][102][103], significant efforts in fully-integrated, organ-specific imaging technologies were made in recent years. For example, Siemens Healthcare did propose a "Brain PET" system that was based on a PET ring insert for a 3 T MR system [104].…”

Section: Organ-specific System Design and Total-body Systemsmentioning

confidence: 99%

Hybrid Imaging: Instrumentation and Data Processing

et al. 2018

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State-of-the-art patient management frequently requires the use of non-invasive imaging methods to assess the anatomy, function or molecular-biological conditions of patients or study subjects. Such imaging methods can be singular, providing either anatomical or molecular information, or they can be combined, thus, providing "anato-metabolic" information. Hybrid imaging denotes image acquisitions on systems that physically combine complementary imaging modalities for an improved diagnostic accuracy and confidence as well as for increased patient comfort. The physical combination of formerly independent imaging modalities was driven by leading innovators in the field of clinical research and benefited from technological advances that permitted the operation of PET and MR in close physical proximity, for example. This review covers milestones of the development of various hybrid imaging systems for use in clinical practice and small-animal research. Special attention is given to technological advances that helped the adoption of hybrid imaging, as well as to introducing methodological concepts that benefit from the availability of complementary anatomical and biological information, such as new types of image reconstruction and data correction schemes. The ultimate goal of hybrid imaging is to provide useful, complementary and quantitative information during patient work-up. Hybrid imaging also opens the door to multi-parametric assessment of diseases, which will help us better understand the causes of various diseases that currently contribute to a large fraction of healthcare costs.

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“…These characteristics also made lutetium-based scintillators the standard detector in high-end commercial PET scanners [49,50]. The shorter decay time of the scintillator also opened up possibilities for use in ToF-PET detectors.…”

Section: Scintillators For Use In Tof-petmentioning

confidence: 99%

Instrumentation for Time-of-Flight Positron Emission Tomography

Ullah

Pratiwi

Cheon

et al. 2016

Nucl Med Mol Imaging

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Positron emission tomography (PET) is a molecular imaging modality that provides information at the molecular level. This system is composed of radiation detectors to detect incoming coincident annihilation gamma photons emitted from the radiopharmaceutical injected into a patient's body and uses these data to reconstruct images. A major trend in PET instrumentation is the development of time-of-flight positron emission tomography (ToF-PET). In ToF-PET, the time information (the instant the radiation is detected) is incorporated for image reconstruction. Therefore, precise and accurate timing recording is crucial in ToF-PET. ToF-PET leads to better localization of the annihilation event and thus results in overall improvement in the signal-to-noise ratio (SNR) of the reconstructed image. Several factors affect the timing performance of ToF-PET. In this article, the background, early research and recent advances in ToF-PET instrumentation are presented. Emphasis is placed on the various types of scintillators, photodetectors and electronic circuitry for use in ToF-PET, and their impact on timing resolution is discussed.

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The ECAT HRRT: performance and first clinical application of the new high resolution research tomograph

Cited by 373 publications

References 13 publications

In vivo Validation of Reconstruction-Based Resolution Recovery for Human Brain Studies

In vivo Validation of Reconstruction-Based Resolution Recovery for Human Brain Studies

Hybrid Imaging: Instrumentation and Data Processing

Instrumentation for Time-of-Flight Positron Emission Tomography

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