The Eaton-Lambert syndrome and autoimmune disorders

Gutmann, Ludwig; Crosby, Thomas W.; Takamori, Masaharu; Martin, James D.

doi:10.1016/0002-9343(72)90179-9

Cited by 90 publications

(23 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients with Lambert Eaton myasthenic syndrome present an increased frequency of autoimmune diseases such as thyroiditis, systemic lupus erythematosus and also positive antibodies for myasthenia gravis 7,9,[16][17][18] . This can be explained by a genetic predisposition to developing autoimmune diseases, which these patients (with primary or paraneoplastic disease) present.…”

Section: Discussionmentioning

confidence: 99%

Lambert-Eaton myasthenic syndrome: Report of two cases

Werneck¹

1997

Electroencephalography and Clinical Neurophysiology

View full text Add to dashboard Cite

-Two cases of Lambert-Eaton myasthenic syndrome, in female patients whose neoplasm investigation was negative, are reported. Repetitive stimulation of ulnar nerve showed an incremental response (+187% and +198%). Needle EMG was normal in one of them, however, the other patient showed fibrillation potentials, positive sharp waves, potentials of low amplitude and short duration. The authors discuss the clinical, electrophysiological, and pathological features of the disease, as well as some aspects of the treatment and follow-up of these patients.KEY WORDS: Lambert-Eaton myasthenic syndrome, neurophysiological study, muscular biopsy, treatment. Síndrome miastênica de Lambert-Eaton: relato de dois casosRESUMO -São descritos dois casos de síndrome miastênica de Lambert-Eaton em pacientes do sexo feminino, nas quais a investigação de neoplasias foi negativa. Os testes de estimulação repetitiva mostraram incrementos de 187 e 198%. A eletromiografia de agulha em um dos casos foi normal e no outro mostrou potenciais de fibrilação, ondas agudas positivas de curta duração e baixa amplitude de potenciais. São discutidos aspectos clínicos, neurofisiológicos, biópsia muscular, tratamento e acompanhamento desta condição rara. PALAVRAS-CHAVE: síndrome miastênica de Lambert-Eaton, estudo neurofisiológico, biópsia muscular, tratamento.Lambert-Eaton myasthenic syndrome is a rare condition, resulting from an acetylcholine release deficiency in the neuromuscular junction. Over 50% of the cases are related with oat cell lung carcinoma [1][2][3] . Lambert-Eaton syndrome has also been associated with squamous cell lung carcinoma, mixed tumors of the parotid glands, systemic mastocytosis, sarcomas, kidney carcinoma and other malignant neoplastic diseases [3][4][5] . As Lambert-Eaton syndrome presents mostly as a paraneoplastic condition, an extensive investigation of malignant tumors should be performed. However, approximately 40% of the patients do not show any evidence of cancer, and in these cases, the disease is considered to be of primary autoimmune origin 1,2 .We report two cases of Lambert-Eaton myasthenic syndrome in female patients whose investigation for neoplastic diseases was negative, and due to the rarity of this type of disease, we found it worth putting on record.

show abstract

Section: Discussionmentioning

confidence: 99%

Lambert-Eaton myasthenic syndrome: Report of two cases

Werneck¹

1997

Electroencephalography and Clinical Neurophysiology

View full text Add to dashboard Cite

show abstract

“…The association of LEMS with autoimmune diseases (Guttmann et al 1972) or organ-specific autoantibodies such as anti-thyroid, anti-gastric, and/or anti-skeletal muscle in LEMS (Lennon et al 1982) have been found. A significant decrease in the proportion of OKT 8+ cells has been described (Robb et al 1985).…”

Section: Discussionmentioning

confidence: 99%

Antibodies to brain proteins in a patient with subacute cerebellar degeneration and Lambert-Eaton myasthenic syndrome.

Tanaka¹,

Tanaka²,

Miyatake³

et al. 1987

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

to Brain Proteins in a Patient with Subacute Cerebellar Degeneration and Lambert -Eaton Myasthenic Syndrome. Tohoku J. exp. Med., 1987, 153 (2), 161-167 The serum IgG of a 50-year-old woman with lung cancer associated with subacute cerebellar degeneration and Lambert-Eaton myasthenic syndrome showed the antibody activity to rat brain proteins.Using an immunoblotting method, the patient serum reacted with 98 kDa neutral cytoplasmic protein and 68 kDa membrane protein.These proteins were different in molecular weight from those we described previously (Tanaka et al. 1986), which suggests that proteins reacting with serum antibody are variable individually among patients with subacute cerebellar degeneration.These proteins from human brain could not be stained by the patient's serum IgG since these antigen proteins needed to be prepared quickly after death under protease inhibitors and were thought to be easily degraded.subacute cerebellar degeneration ; Lambert-Eaton myasthenic syndrome ; serum antibody ; brain protein ; immunoblotting In paraneoplastic syndromes as remote effects of cancer, that involve the nervous system, subacute cerebellar degeneration, Lambert-Eaton myasthenic syndrome (LEMS), visual paraneoplastic syndrome and carcinomatous sensory neuropathy might be mediated by antibodies. We previously investigated the antigenic determinants of serum antibody in a patient with subacute cerebellar degeneration by an immunoblotting method (Tanaka et al. 1986). We here

show abstract

“…Cases have also been reported with cancers of breast, prostate, stomach and rectum [13], non-infiltrating papillary transitional cell carcinoma of bladder [15], reticulum cell sarcoma [24], and in patients suffering from Sjogren's syndrome [3], kidney stones [12], peripheral neuropathy [26] and thyrotoxi cosis (report of 1 patient with benign pros tatic hypertrophy, a past history of excised basal cell carcinomas of the face and excised benign rectal polyps [21]. There is one report of a case of hypothyroidism with per nicious anaemia [10] and several examples of patients in whom despite intensive in vestigation and follow-up (some with post mortem findings included), no other patho logical entity could be discovered [2,12,24].…”

Section: Discussionmentioning

confidence: 99%

“…Despite reports of cases with features of both disor ders [20,28], this contrasts sharply with classical myasthenia gravis, in which muscu lar weakness results from impaired neuro muscular transmission caused by reduced sensitivity of the post-synaptic membrane to acetylcholine (because antibodies cause loss of acetylcholine receptors [4,9,18], and in which there is a well-documented associa tion with autoimmune disorders. We have found only three reports linking myasthenic syndrome to diseases with autoimmune con comitants [3,10,21].…”

Section: Discussionmentioning

confidence: 99%

“…Examina tion of the thymus in patients dying with the myasthenic syndrome does not show histopathological changes of the type seen in myasthenia gravis [13], An association between myasthenic syn drome and bronchial and other malignan cies has been widely reported [2, 6, 7, 13-17, 23, 24], and it has also been de scribed in the absence of neoplastic disease [2,3,10,12,21,26], but myasthenia gravis has been found in connection with neo plasms (thymoma excepted) with only the same frequency that one would expect in the general population [25], Finally, the pathogenic mechanisms of the two condi tions differ (vide infra).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chronic Myeloid Leukaemia and a Myasthenic Syndrome

Wohl¹,

Wood²

1979

Acta Haematol

View full text Add to dashboard Cite

This is the first report of a case of chronic myeloid leukaemia (CML) complicated by myasthenic syndrome. The patient suffered two prolonged periods of idiosyncratic busulphan-induced marrow aplasia, the first occurring 5 months after busulphan was stopped. Between these two episodes, and at a time when no therapy was required for the leukaemia, myasthenic syndrome developed. After the patient recovered from the second episode, the myasthenic syndrome disappeared, and, despite subsequent recrudescence of CML, there were no further myasthenic symptoms, and treatment with neostigmine was discontinued.

show abstract

The Eaton-Lambert syndrome and autoimmune disorders

Cited by 90 publications

References 3 publications

Lambert-Eaton myasthenic syndrome: Report of two cases

Lambert-Eaton myasthenic syndrome: Report of two cases

Antibodies to brain proteins in a patient with subacute cerebellar degeneration and Lambert-Eaton myasthenic syndrome.

Chronic Myeloid Leukaemia and a Myasthenic Syndrome

Contact Info

Product

Resources

About