The early phase response of rat alveolar bone to traumatic occlusion

Abstract

These results suggested that at early phase of the occlusal trauma, osteogenesis in rat's alveolar bone was inhibited, and osteoclastogenesis was not significant.

Occlusal trauma accelerates attachment loss at the onset of experimental periodontitis in rats

“…Methods to induce experimental occlusal trauma by bonding an excessive‐height inlay on rodent molars have been reported . These models are well suited for investigations of periodontal breakdown, but the traumatic forces in these models gradually decrease .…”

β-catenin and Its Relation to Alveolar Bone Mechanical Deformation – A Study Conducted in Rats With Tooth Extraction

“…Animal models provide relevant information about a variety of disorders in dentistry. The rat model has been widely used for studies in dentistry, including those which involve periodontal diseases, alveolar bone healing, tooth movement, osteogenesis, osseointegration, use of biomaterials, and altered occlusal loadings, for example (Okamoto and de Russo, 1973;Shimomoto et al, 2007;Walker et al, 2008;Wan et al, 2012;Xu et al, 2016;Zeng et al, 2016;Koutouzis et al, 2017;Lee et al, 2017;Hassumi et al, 2018;Palin et al, 2018;Uslu et al, 2018;Wang et al, 2018). Besides that, tooth extraction, inclosing incisor extraction, has been considered as a classical model of preclinical studies and has been applied in many studies with different aims in the last years (Avivi-Arber et al, 2010;Shoji et al, 2010;Boonyagul et al, 2014;Curra et al, 2016;Hassumi et al, 2018;de Oliveira Puttini et al, 2019).…”

“…Dental occlusal trauma plays an important role in alveolar bone remodeling and its effects includes many cytokines and signaling pathways. However, the exact mechanism of the traumatic stimulus for alveolar bone remodeling is still unclear (Wan et al, 2012). Changes in mechanical stimulation as a result of dental extraction can lead to changes in bone tissue.…”

Mechanical loading on the functional activity of carbonic anhydrase II in the periodontium

“…Primary occlusal trauma has been defined as an injury to the attachment apparatus as result of excessive occlusal force applied to a tooth or teeth with normal and healthy support tissues (Davies, et al, 2001). It can affect tooth mobility (Harrel & Nunn, 2001), fremitus, persistent discomfort or pain on eating (Wan, et al, 2012) and aseptic pulp necrosis.…”

“…In the first 24 hours of traumatic dental occlusion (TDO), osteogenesis in the rats, alveolar bone was inhibited, and osteoclastogenesis was not significant (Wan, et al, 2012).…”