The Early History of Tubulation in Nerve Repair

IJpma, Frank F. A.; Graaf, Robert C. van de; Meek, Marcel F.

doi:10.1177/1753193408091349

Cited by 53 publications

(28 citation statements)

References 9 publications

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“…Peripheral nerve defects of more than 10 mm are commonly treated in clinics, and in these injuries a conduit is needed to bridge the gap, prevent the formation of obstacles to nerve regeneration, and guide axonal regrowth[56]. During the past 20 years, different conduits have been used to bridge peripheral nerve defects, including veins[789], arteries[1011], muscle fiber tubes[1213], decalcified bone tubes[14], and artificial nerve conduits[15161718]. Traditionally, the effectiveness of nerve conduits was evaluated by analysis of nerve fiber density in the nerve conduit or the distal nerve stump[1920].…”

Section: Introductionmentioning

confidence: 99%

Sensory reinnervation of muscle spindles after repair of tibial nerve defects using autogenous vein grafts

2014

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Motor reinnervation after repair of tibial nerve defects using autologous vein grafts in rats has previously been reported, but sensory reinnervation after the same repair has not been fully investigated. In this study, partial sensory reinnervation of muscle spindles was observed after repair of 10-mm left tibial nerve defects using autologous vein grafts with end-to-end anastomosis in rats, and functional recovery was confirmed by electrophysiological studies. There were no significant differences in the number, size, or electrophysiological function of reinnervated muscle spindles between the two experimental groups. These findings suggest that repair of short nerve defects with autologous vein grafts provides comparable results to immediate end-to-end anastomosis in terms of sensory reinnervation of muscle spindles.

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Section: Introductionmentioning

confidence: 99%

Sensory reinnervation of muscle spindles after repair of tibial nerve defects using autogenous vein grafts

2014

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“…The use of hollow NGCs was originally proposed for use for nerve repair as early as 1881 with the first successful application occurring in 1882, where a hollow bone tube was used to bridge a 30 mm nerve gap in a dog [19]. Today, the use of hollow NGCs is the clinically approved alternative to autograft repair.…”

Section: The Development Of Nerve Guidance Conduitsmentioning

confidence: 99%

A biomaterials approach to peripheral nerve regeneration: bridging the peripheral nerve gap and enhancing functional recovery

Daly

Yao

Zeugolis

et al. 2011

J. R. Soc. Interface.

490

508

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Microsurgical techniques for the treatment of large peripheral nerve injuries (such as the gold standard autograft) and its main clinically approved alternative-hollow nerve guidance conduits (NGCs)-have a number of limitations that need to be addressed. NGCs, in particular, are limited to treating a relatively short nerve gap (4 cm in length) and are often associated with poor functional recovery. Recent advances in biomaterials and tissue engineering approaches are seeking to overcome the limitations associated with these treatment methods. This review critically discusses the advances in biomaterial-based NGCs, their limitations and where future improvements may be required. Recent developments include the incorporation of topographical guidance features and/or intraluminal structures, which attempt to guide Schwann cell (SC) migration and axonal regrowth towards their distal targets. The use of such strategies requires consideration of the size and distribution of these topographical features, as well as a suitable surface for cell-material interactions. Likewise, cellular and molecular-based therapies are being considered for the creation of a more conductive nerve microenvironment. For example, hurdles associated with the short half-lives and low stability of molecular therapies are being surmounted through the use of controlled delivery systems. Similarly, cells (SCs, stem cells and genetically modified cells) are being delivered with biomaterial matrices in attempts to control their dispersion and to facilitate their incorporation within the host regeneration process. Despite recent advances in peripheral nerve repair, there are a number of key factors that need to be considered in order for these new technologies to reach the clinic.

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“…Nerve tubulation approach to the repair of peripheral nerve gaps can be traced back to the nineteenth century. Gluck (Gluck, 1881) performed the first experiment of nerve tabulation, with a tube of decalcified bone to aid the approximation of transected nerve ends, in animals [78,84,85]. Later, Dahlin and Lundborg [86] developed the first synthetic tube, made of silicone.…”

Section: Nerve Conduitsmentioning

confidence: 99%

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Pedrosa¹,

Caseiro²,

Santos³

et al. 2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

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Human adult peripheral nerve injuries are a high incidence clinical problem that greatly affects patients' quality of life. Although peripheral nervous system has intrinsic regenerative capacity, this occurs in an incomplete or poorly functional manner. When a nerve fiber loses its continuity with consequent damage of the basal lamina tubes, axon spontaneous regeneration is disorganized and mismatched. These phenomena translate in an inadequate nerve functional recovery and consequent musculoskeletal incapacity. Nerve grafts still remain the gold standard in peripheral injuries treatment. However, this approach contains its disadvantages such as the necessity of primary surgery to harvest the autografts, loss of a functional nerve, donor site morbidity and longer surgery procedures. Therefore, biomaterials and tissue engineering can provide efficient resources and alternatives to nerve injury repair not only by the development of biocompatible structures but also, introducing neurotrophic factors and cellular systems to stimulate optimum clinical outcome. In this chapter, a comprehensive state-of-the art picture of tissue-engineered nerve grafts scaffolds, their application in nerve regeneration along with latest advances in peripheral nerve repair and future perspectives will be discussed, including our own large experience in this field of knowledge.

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The Early History of Tubulation in Nerve Repair

Cited by 53 publications

References 9 publications

Sensory reinnervation of muscle spindles after repair of tibial nerve defects using autogenous vein grafts

Sensory reinnervation of muscle spindles after repair of tibial nerve defects using autogenous vein grafts

A biomaterials approach to peripheral nerve regeneration: bridging the peripheral nerve gap and enhancing functional recovery

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

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