The early erosive vesicular stage of lipoid proteinosis: clinical and histopathological features

Lipoid Proteinosis: An Unusual Presentation with Verruca Vulgaris

“…Beaded eyelid papules, which are quite characteristic, are easily recognized. In adulthood, although rare, an unusual presentation may have no cutaneous manifestations but have visceral involvement (10). Luckily, our patient did not show any central nervous system involvement, because there can be calcifications in the temporal lobe identified by brain computed tomography which could lead to epileptic seizures or neuropsychological disturbances (2, 3).…”

Lipoid proteinosis: a case series from Istanbul

“…In our literature search, we found reports concerning 23 further patients from different clinics (excluding the cases reported in our clinic) throughout Turkey (Table 2). Of these reported cases, 12 were published in the English literature 6–8,12,15,17,19–21 , six were published in the Turkish literature, 9–11,13,22 and five patients were presented in national congresses only 5,14,16,18,23 . The reports originated from medical centers in 10 different cities in Turkey, but the places of birth of the patients were not stated in most cases.…”

“…Although various agents have been used, no effective therapy is available for LP. Limited success has been claimed with dimethyl sulfoxide, 4,37 oral corticosteroids, 21 etretinate, 47 and d ‐penicillamine 20 . Facial lesions have been treated successfully by dermabrasion, chemical peeling, blepharoplasty, and CO 2 laser 48–50 …”

“…We have observed 14 LP patients belonging to nine different families in our university clinic since 1990 (five have been reported elsewhere) 3–5 . In the current study, we reviewed all reported Turkish patients with a diagnosis of LP between 1991 and 2005 from the relevant literature, including national congress reports 6–23 . The total number of LP patients reached 37, including our nine newly diagnosed patients.…”

Lipoid proteinosis: Histopathological characterization of early papulovesicular lesions

“…reported epidermal atrophy, scale crust, extravasation of RBCs, extremely narrowed and eroded dermal papillae along with deposition of hyaline material within the dermis and vessel walls and speculated that abrupt increase in the amorphous mass might be the cause of epidermal atrophy and ulcerations might be due to the blockage of the capillary circulation in the papillary dermis as a result of perivascular depositions. [7]…”