The early diversification of influenza A/H1N1pdm

Nelson, Martha I.; Spiro, David; Wentworth, David E.; Beck, Eric T.; Fan, Jun; Ghedin, Elodie; Halpin, Rebecca; Bera, Jayati; Hine, Erin; Proudfoot, Kathleen; Stockwell, Tim; Lin, Xudong; Griesemer, Sara B.; Kumar, Swati; Bose, Michael E.; Viboud, Cécile; Holmes, Edward C.; Henrickson, Kelly J.

doi:10.1371/currents.rrn1126

Cited by 127 publications

(207 citation statements)

References 18 publications

Supporting

Mentioning

187

Contrasting

Unclassified

Order By: Relevance

“…They have been previously reported by Ledesma et al (10), who demonstrated that Spanish viruses carried D97N, S83P, S185T, and V321I mutations, which were also found in the viruses circulating in Poland. Remarkably, P83 and I321 points diagnosed only in the HA gene of 134312 virus were present in the vaccine A/H1 component, and the first pandemic A(H1N1)2009 isolates were all classified in one pattern group (15). the S185T mutation, which occurred in A/Poland/031925/2012 virus, was identical as in the previously identified Northern hemisphere pdm SIV and the SIVs widely spread in Spain (10).…”

Section: Discussionsupporting

confidence: 52%

Substitution in position 222 of haemagglutinin of pandemic influenza A (H1N1) viruses isolated from pigs in Poland

Kowalczyk

Urbaniak

Markowska-Daniel

et al. 2015

Bulletin of the Veterinary Institute in Pulawy

View full text Add to dashboard Cite

The aim of the study was to monitor genetic diversity and antigenic changes in the genome of influenza A(H1N1)pdm09 viral isolates detected during the post-pandemic period in Poland. Clinical specimens obtained from three suspected cases of influenza were analysed by sequencing. Among the differences identified in amino acids sequences, nine substitutions were located within the antigenic HA1 sites and in five residues forming receptor-binding pocket. The HA(D222G) mutation was shown in the isolate Swine/Poland/134312/12 obtained from a mild case of the disease. It must be emphasized that, in general, clinically mild cases are caused by the viruses in which that specific mutation, i.e. haemagglutinin (D222G), does not occur.

show abstract

Section: Discussionsupporting

confidence: 52%

Substitution in position 222 of haemagglutinin of pandemic influenza A (H1N1) viruses isolated from pigs in Poland

Kowalczyk

Urbaniak

Markowska-Daniel

et al. 2015

Bulletin of the Veterinary Institute in Pulawy

View full text Add to dashboard Cite

show abstract

“…Therefore, the amino acid changes mapped in the NA (V106I and N248D) and the S203T (S220T) mapped in the HA indicated that the majority of isolates from the three countries seems to belong to clades 3, 6, and 7, which is in agreement with recent results. 13 The P83S (P100S) and I321V (I338V) were mapped in all isolates, and the S203T (S220T) was in 8 of 14 sequenced isolates. It is important to specify that, in a recent study conducted in Brazil, 22 the S220T mutation was identified in 78.6% of fatal pandemic influenza cases.…”

Section: Discussionmentioning

confidence: 98%

A Subregional Analysis of Epidemiologic and Genetic Characteristics of Influenza A(H1N1)pdm09 in Africa: Senegal, Cape Verde, Mauritania, and Guinea, 2009–2010

Dia

Ndiaye²,

Monteiro³

et al. 2013

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. During the pandemic 2009 episode, we conducted laboratory-based surveillance in four countries from West Africa: Senegal, Mauritania, Cape Verde, and Guinea. Specimens were obtained from 3,155 patients: 2,264 patients from Senegal, 498 patients from Cape Verde, 227 patients from Mauritania, and 166 patients from Guinea; 911 (28.9%) patients were positive for influenza, 826 (90.7%) patients were positive for influenza A, and 85 (9.3%) patients were positive for influenza B. Among the influenza A positives, 503 (60.9%) positives were H1N1pdm09, 314 (38.0%) positives were H3N2, and 9 (1.1%) positives were seasonal H1N1. The highest detection rate for seasonal influenza viruses (17.1%) occurred in the 5-14 years age group. However, for A(H1N1)pdm09, the detection rate was highest in the 15-24 years age group (35.8%). Based on the present study data, the timeline of detection of A(H1N1)pdm09 viruses in these four countries should be Cape Verde, Guinea, Mauritania, and finally, Senegal. Genetic and antigenic analyses were performed in some isolates.

show abstract

“…This study clearly indicates that the cosmopolitan clade VII viruses are continuously circulating in India. This molecular epidemiology information will facilitate better pandemic planning and response capacity for future epidemiological surveillance in Indian subcontinent and abroad [22][23][24][25][26][27][28][29].…”

Section: Discussionmentioning

confidence: 99%

Laboratory Investigation and Molecular Epidemiology of H1N1pdm Virus 2012-2013 from India

Sharma¹,

Joshi²,

K³

et al. 2015

J Phylogenetics Evol Biol

View full text Add to dashboard Cite

Influenza A virus is the most unpredictable global threat, past pandemic witnessed the community swaps happened due to this virus. The recent emergence of H7N9 in China is the result of new and recent reassortmant of Influenza A virus. Emergence of a novel human influenza A virus (H1N1pdm) in 2009 is an unprecedent event of molecular virology. This novel emerged virus affected millions of persons and raised WHO pandemic alert to phase 6. Therefore continuous monitoring is required to have adequate genome information and to track mutations during course of viral evolution. In present study we investigated acute phase suspected In the course of its evolution, 2009-2013 the virus acquired many mutations and which could be responsible for severity of this virus and emergence of new virus subtypes. India also witnessed high morbidity and mortality reported from all parts of the country. This study clearly indicates that recently reported cosmopolitan clade VII has undergone positive selection in India as well globally revealed continuous circulation of clade VII since 2009. This study of recent H1N1pdm Indian virus isolate will facilitate future epidemiological surveillance in Indian subcontinent and abroad.

show abstract

The early diversification of influenza A/H1N1pdm

Abstract: Background Since its initial detection in April 2009, the A/H1N1pdm influenza virus has spread rapidly in humans, with over 5,700 human deaths. However, little is known about the evolutionary dynamics of H1N1pdm and its geographic and temporal diversification.

Cited by 127 publications

References 18 publications

Substitution in position 222 of haemagglutinin of pandemic influenza A (H1N1) viruses isolated from pigs in Poland

Substitution in position 222 of haemagglutinin of pandemic influenza A (H1N1) viruses isolated from pigs in Poland

A Subregional Analysis of Epidemiologic and Genetic Characteristics of Influenza A(H1N1)pdm09 in Africa: Senegal, Cape Verde, Mauritania, and Guinea, 2009–2010

Laboratory Investigation and Molecular Epidemiology of H1N1pdm Virus 2012-2013 from India

Contact Info

Product

Resources

About