The early diagnostic value of serum neopterin and cartilage oligomeric matrix protein for osteoarticular changes among brucellosis patients at an early period

Zhao, Zhijun; Li, Qiang; Ma, Lian; Li, Jiquan; Xu, Liqing

doi:10.1186/s13018-018-0932-9

Cited by 6 publications

(4 citation statements)

References 22 publications

(25 reference statements)

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“…15 Brucellosis epidemics have been reported in 32 provinces (autonomous regions) in mainland China. 12 It is classified as a class B statutory infectious disease in China 3 and is considered a public health problem endangering health and property in China. [15][16][17] Early warning is important for controlling or reducing the risk of infectious disease outbreaks, and it is therefore vital to ensure the accuracy of Brucellosis predictions.…”

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confidence: 99%

Comparison of ARIMA model and XGBoost model for prediction of human brucellosis in mainland China: a time-series study

Alim

Guan

et al. 2020

BMJ Open

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ObjectivesHuman brucellosis is a public health problem endangering health and property in China. Predicting the trend and the seasonality of human brucellosis is of great significance for its prevention. In this study, a comparison between the autoregressive integrated moving average (ARIMA) model and the eXtreme Gradient Boosting (XGBoost) model was conducted to determine which was more suitable for predicting the occurrence of brucellosis in mainland China.DesignTime-series study.SettingMainland China.MethodsData on human brucellosis in mainland China were provided by the National Health and Family Planning Commission of China. The data were divided into a training set and a test set. The training set was composed of the monthly incidence of human brucellosis in mainland China from January 2008 to June 2018, and the test set was composed of the monthly incidence from July 2018 to June 2019. The mean absolute error (MAE), root mean square error (RMSE) and mean absolute percentage error (MAPE) were used to evaluate the effects of model fitting and prediction.ResultsThe number of human brucellosis patients in mainland China increased from 30 002 in 2008 to 40 328 in 2018. There was an increasing trend and obvious seasonal distribution in the original time series. For the training set, the MAE, RSME and MAPE of the ARIMA(0,1,1)×(0,1,1)12 model were 338.867, 450.223 and 10.323, respectively, and the MAE, RSME and MAPE of the XGBoost model were 189.332, 262.458 and 4.475, respectively. For the test set, the MAE, RSME and MAPE of the ARIMA(0,1,1)×(0,1,1)12 model were 529.406, 586.059 and 17.676, respectively, and the MAE, RSME and MAPE of the XGBoost model were 249.307, 280.645 and 7.643, respectively.ConclusionsThe performance of the XGBoost model was better than that of the ARIMA model. The XGBoost model is more suitable for prediction cases of human brucellosis in mainland China.

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confidence: 99%

Comparison of ARIMA model and XGBoost model for prediction of human brucellosis in mainland China: a time-series study

Alim

Guan

et al. 2020

BMJ Open

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“…The monitoring of the serological Nep may be helpful for the prediction of the death risk from acute pancreatitis [ 100 ]. The Nep level may be a biomarker for osteoarticular changes of human brucellosis at an early stage [ 101 ]. The C-reactive protein and Nep serum levels are significantly higher in patients with gastric intestinal metaplasia and gastric atrophy: the best cut-off value to differentiate between patients with metaplasia and/or atrophy from controls was ≥10.15 nM for the Nep levels and ≥1.95 mg l −1 for the C-reactive protein levels [ 102 ].…”

Section: Different Oxidation States Relate To Different Biological Ro...mentioning

confidence: 99%

Insights into Molecular Structure of Pterins Suitable for Biomedical Applications

Buglak

Kapitonova

Vechtomova

et al. 2022

IJMS

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Pterins are an inseparable part of living organisms. Pterins participate in metabolic reactions mostly as tetrahydropterins. Dihydropterins are usually intermediates of these reactions, whereas oxidized pterins can be biomarkers of diseases. In this review, we analyze the available data on the quantum chemistry of unconjugated pterins as well as their photonics. This gives a comprehensive overview about the electronic structure of pterins and offers some benefits for biomedicine applications: (1) one can affect the enzymatic reactions of aromatic amino acid hydroxylases, NO synthases, and alkylglycerol monooxygenase through UV irradiation of H4pterins since UV provokes electron donor reactions of H4pterins; (2) the emission properties of H2pterins and oxidized pterins can be used in fluorescence diagnostics; (3) two-photon absorption (TPA) should be used in such pterin-related infrared therapy because single-photon absorption in the UV range is inefficient and scatters in vivo; (4) one can affect pathogen organisms through TPA excitation of H4pterin cofactors, such as the molybdenum cofactor, leading to its detachment from proteins and subsequent oxidation; (5) metal nanostructures can be used for the UV-vis, fluorescence, and Raman spectroscopy detection of pterin biomarkers. Therefore, we investigated both the biochemistry and physical chemistry of pterins and suggested some potential prospects for pterin-related biomedicine.

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“…In human brucellosis, it would seem that abnormal musculoskeletal changes are present during the early stage despite changes being undetectable via radiography. While a few studies have identified serum cartilage oligomeric matrix protein (COMP) and C-terminal telopeptide of type II collagen (CTX-II) as biomarkers that are associated with brucellosis-induced musculoskeletal changes 11 , 12 , there is still a need to identify potential bone markers that can identify early changes and aid in an early diagnosis. When assessing osteoarthritis (OA), commonly utilized biomarkers include pyridinoline (PYD), type II collagen cleavage neoepitope (C2C), and osteocalcin (OC).…”

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confidence: 99%

Serum changes in pyridinoline, type II collagen cleavage neoepitope and osteocalcin in early stage male brucellosis patients

Zhao

et al. 2020

Sci Rep

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Musculoskeletal changes are the most common clinical manifestation of brucellosis. The main objective of this study was to provide a better understanding of this disease, while also attempting to identify potential markers that can identify the early stage musculoskeletal changes associated with human brucellosis. In this case–control study, 41 male early-stage brucellosis patients (within 6 months of diagnosis) who had not received drug therapy and 44 matched controls were examined. Venous blood samples were collected and serum pyridinoline (PYD), type II collagen cleavage neoepitope (C2C) and osteocalcin (OC) levels were quantified using an enzyme-linked immunosorbent assay (ELISA). In the brucellosis group, the median serum levels of PYD (278.53 µg/L), C2C (82.23 µg/L) and OC (8.41 µg/L) were significantly elevated relative to the control group (Z = 5.686, 3.997, 3.579; P = 0.000). Serum PYD, C2C, and OC levels were increased in early-stage male brucellosis patients, and these factors appear to have promise as potential indicator biomarkers that can reflect the osteoarticular changes that occur in the early stage of human brucellosis.

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The early diagnostic value of serum neopterin and cartilage oligomeric matrix protein for osteoarticular changes among brucellosis patients at an early period

Cited by 6 publications

References 22 publications

Comparison of ARIMA model and XGBoost model for prediction of human brucellosis in mainland China: a time-series study

Comparison of ARIMA model and XGBoost model for prediction of human brucellosis in mainland China: a time-series study

Insights into Molecular Structure of Pterins Suitable for Biomedical Applications

Serum changes in pyridinoline, type II collagen cleavage neoepitope and osteocalcin in early stage male brucellosis patients

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