The E3 ubiquitin ligase RNF146 promotes colorectal cancer by activating the Wnt/β-catenin pathway via ubiquitination of Axin1

Shen, Jiangli; Yu, Zhaohui; Li, Na

doi:10.1016/j.bbrc.2018.06.107

Cited by 28 publications

(27 citation statements)

References 18 publications

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“…In addition, it is recognized that ubiquitination system serves a crucial role in tumor genesis and development, including invasion and metastasis. E3 ubiquitination ligands have been reported to have important clinical significance in the regulation of cell motility and of tumor invasion and metastasis (24,25). Molecules with such structures and functions may therefore play a crucial role in tumor invasion and metastasis and may have potential value in clinical research.…”

Section: Discussionmentioning

confidence: 99%

Lower expression of PDZRN3 induces endometrial carcinoma progression via the activation of canonical Wnt signaling

Li¹,

Zhong²,

Yang

et al. 2022

Oncol Lett

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Endometrial carcinoma (EC) exhibits an extremely malignant biological behavior and has a high mortality rate. EC has recently become one of the most lethal cancers in women worldwide. E3 ubiquitin ligases play an important role in the biological function of healthy cells but can also contribute to tumorigenesis and cancer development. PDZ Domain Containing Ring Finger 3 (PDZRN3) is associated with cell differentiation and its structure includes the E3 ubiquitin ligase. However, the effects of PDZRN3 in EC remain unclear. Reverse transcription-quantitative PCR was used to detect the expression levels of PDZRN3 in EC cells, and the role of PDZRN3 in EC progression was determined using western blotting, MTT, colony formation, Transwell, subcutaneous tumor formation and pulmonary metastasis assays. A multi-pathway reporter arrays and western blotting were performed to investigate the potential biological mechanisms of PDZRN3 in EC. The present study demonstrated that PDZRN3 served an essential role in metastasis and proliferation of EC. PDZRN3 expression was lower in EC tissues compared with that in normal endometrial tissues. Low expression level of PDZRN3 in EC was correlated with certain clinicopathological features of patients with EC, such as the age of the patients, the tumor grade and the tumor subtype. The invasive and proliferative activities of EC cells with low expression of PDZRN3 were more potent than those of EC cells with high expression of PDZRN3, which was confirmed by in vivo and in vitro experiments. Furthermore, lower expression of PDZRN3 promoted metastasis and proliferation via activation of the canonical Wnt signaling pathway. The present study demonstrated that decreased PDZRN3 expression promoted metastasis and proliferation in EC cells via activation of the canonical Wnt signaling pathway, highlighting a potential biological therapeutic target for the management of EC.

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Section: Discussionmentioning

confidence: 99%

Lower expression of PDZRN3 induces endometrial carcinoma progression via the activation of canonical Wnt signaling

Li¹,

Zhong²,

Yang

et al. 2022

Oncol Lett

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“…Wnt signaling pathway plays essential parts in the regulation of cell cycle and differentiation, and the deregulation of its canonical (β-catenin-dependent) pathway has greater implications for the initiation and progression of various types of human cancers [37]. Previously, RING finger ubiquitin ligases have been reported to affect the stemness and metastasis of gastrointestinal related cancers through regulating Wnt/ β-catenin signaling pathway [38][39][40][41]. In accordance with these findings, we also revealed that the underlying mechanism of the LUAD-promotive functions of RNF115, found in this study, is at least partially via modulating Wnt canonical signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

RNF115 promotes lung adenocarcinoma through Wnt/β-catenin pathway activation by mediating APC ubiquitination

Wang

Cai

et al. 2021

Cancer Metab

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Background Patients with lung adenocarcinoma (LUAD) have high mortality rate and poor prognosis. The LUAD cells display increased aerobic glycolysis, which generates energy required for their survival and proliferation. Deregulation of Wnt/β-catenin signaling pathway induces the metabolism switching and oncogenesis in tumor cells. RING finger protein 115 (RNF115) is an E3 ligase for ubiquitin-mediated degradation. Although the oncogenic functions of RNF115 have been revealed in breast tumor cells, the effect of RNF115 on lung cancer is still not clear. Methods RNF115 expression and its correlation with the features of LUAD patients were analyzed by using public database and our own cohort. The functions of RNF115 in proliferation and energy metabolism in LUAD cells were explored by downregulating or upregulating RNF115 expression. Results We demonstrated that RNF115 was overexpressed in LUAD tissues and its expression was positively correlated with the poor overall survival of LUAD patients. Moreover, RNF115 overexpression inhibited LUAD cell apoptosis and promoted cellular proliferation and metabolism in LUAD cells. On the contrary, RNF115 knockdown displayed reverse effects. Furthermore, the underlying mechanism of the biological function of RNF115 in LUAD was through regulating Wnt/β-catenin pathway via ubiquitination of adenomatous polyposis coli (APC). Conclusion The current study reveals a close association between RNF115 expression and prognostic conditions in LUAD patients and the oncogenic roles of RNF115 in LUAD at the first time. These findings may help establish the foundation for the development of therapeutics strategies and clinical management for lung cancer in future.

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“…Additionally, negative regulatory targets inhibit cRc progression via inactivating Wnt/β-catenin signaling, and these targets include tumor suppressor genes (167,168), metastasis-suppressor genes (169), ubiquitin-like proteins (170) and anticancer bioactive peptides (171). In the present review, the effects of these therapy targets on cRc in the Wnt/β-catenin signaling pathway are presented in Table II (3,4,21,35,52,60,105,(160)(161)(162)(163)(164)(165)(166)(167)(168)(169)(170)(171)(172)(173)(174)(175)(176)(177)(178).…”

Section: Exogenous Modifier-associated Targetsmentioning

confidence: 99%

“…In addition to the aforementioned studies, researchers have found several other Wnt/β-catenin signaling-associated targets for CRC therapy. These targets include functional oncogenes ( 160 - 162 ), epidermal growth factor-like proteins ( 163 ), adaptor proteins ( 4 ), stomatin-like proteins ( 164 ), chromatin organizers ( 165 ), antioxidants ( 166 ), and architectural transcription factors ( 105 ), which promote CRC growth via activating Wnt/β-catenin signaling. Additionally, negative regulatory targets inhibit CRC progression via inactivating Wnt/β-catenin signaling, and these targets include tumor suppressor genes ( 167 , 168 ), metastasis-suppressor genes ( 169 ), ubiquitin-like proteins ( 170 ) and anticancer bioactive peptides ( 171 ).…”

Section: Therapeutic Strategies Targeting Wnt/β-catenin Signaling For Crcmentioning

confidence: 99%

Therapeutic strategies targeting Wnt/β‑catenin signaling for colorectal cancer (Review)

Sun

et al. 2021

Int J Mol Med

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colorectal cancer (cRc) is one of the most common carcinomas. Although great progress has been made in recent years, cRc survival remains unsatisfactory due to high metastasis and recurrence. Understanding the underlying molecular mechanisms of cRc tumorigenesis and metastasis has become increasingly important. Recently, aberrant Wnt/β-catenin signaling has been reported to be strongly associated with cRc tumorigenesis, metastasis and recurrence. Therefore, the Wnt/β-catenin signaling pathway has potential value as a therapeutic target for cRc. In the present review, the dysregulation of this pathway in cRc and the promoting or suppressing function of therapeutic targets on cRc were explored. In addition, the interaction between this pathway and epithelial-mesenchymal transition (EMT), cell stemness, mutations, metastasis-related genes and tumor angiogenesis in cRc cells were also investigated. Numerous studies on this pathway may help identify the potential diagnostic and prognostic markers and therapeutic targets for cRc. Contents1. Introduction 2. Role of Wnt/β-catenin signaling in colorectal cancer (cRc) 3. Therapeutic strategies targeting Wnt/β-catenin signaling for cRc 4. challenges in targeting Wnt/β-catenin signaling in cRc 5. conclusions and future perspectives

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The E3 ubiquitin ligase RNF146 promotes colorectal cancer by activating the Wnt/β-catenin pathway via ubiquitination of Axin1

Cited by 28 publications

References 18 publications

Lower expression of PDZRN3 induces endometrial carcinoma progression via the activation of canonical Wnt signaling

Lower expression of PDZRN3 induces endometrial carcinoma progression via the activation of canonical Wnt signaling

RNF115 promotes lung adenocarcinoma through Wnt/β-catenin pathway activation by mediating APC ubiquitination

Therapeutic strategies targeting Wnt/β‑catenin signaling for colorectal cancer (Review)

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