The E2 antigen, a 32 kd glycoprotein involved in T-cell adhesion processes, is the MIC2 gene product.

Gélin, Catherine; Aubrit, F; Phalipon, Armelle; Raynal, B; Cole, Susan P.C.; Kaczorek, Michel; Bernard, Alain

doi:10.1002/j.1460-2075.1989.tb08485.x

Cited by 150 publications

(85 citation statements)

References 36 publications

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“…Among normal tissues, CD99 has been shown to be highly expressed on pancreatic islet cells, Leydig and Sertoli cells (Ambros et al, 1991). In the hematopoietic system, the level of CD99 expression decreases with the degree of differentiation, with early T-and B-precursors showing the highest CD99 positivity (Gelin et al, 1989;Dworzak et al, 1994Dworzak et al, , 1999. Similarly, an inverse association of CD99 with differentiation has been demonstrated recently for osteoblasts (Bertaux et al, 2005).…”

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confidence: 77%

Suppression of KCMF1 by constitutive high CD99 expression is involved in the migratory ability of Ewing's sarcoma cells

et al. 2005

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High CD99 expression levels and rearrangements of the EWS gene with ETS transcription factor genes characterize the Ewing's sarcoma family of tumors (ESFT). CD99 is a cell surface glycoprotein whose engagement has been implicated in cell proliferation as well as upregulation and transport of several transmembrane proteins in hematopoietic cells. In ESFT, antibody ligation of CD99 induces fast homotypic cell aggregation and cell death although its functional role in these processes remains largely unknown. Here, using an RNAi approach, we studied for the first time the consequences of modulated CD99 expression in six different ESFT cell lines, representing the most frequent variant forms of EWS gene rearrangement. CD99 suppression resulted in growth inhibition and reduced migration of ESFT cells. Among genes whose expression changes in response to CD99 modulation, the potassium-channel modulatory factor KCMF1 was consistently upregulated. In a series of 22 primary ESFT, KCMF1 expression levels inversely correlated with CD99 abundancy. Cells forced to express ectopic KCMF1 showed a similar reduction in migratory ability as CD99 silenced ESFT cells. Our results suggest that in ESFT, high CD99 expression levels contribute to the malignant properties of ESFT by promoting growth and migration of tumor cells and identify KCMF1 as a potential metastasis suppressor gene downregulated by high constitutive CD99 expression in ESFT.

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confidence: 77%

Suppression of KCMF1 by constitutive high CD99 expression is involved in the migratory ability of Ewing's sarcoma cells

et al. 2005

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“…The antigen is highly expressed on thymocytes, Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) cells, pancreatic islet cells and leydig and Sertorli cells (Fellinger et al, 1991;Dworzak et al, 1994), and is expressed in other hematopoietic cells at moderate levels (Hahn et al, 1997). Originally, CD99 was described as a human thymus leukemia antigen, Ewing's sarcomaspecific membrane marker molecule, and a putative adhesion molecule (termed E2) involved in spontaneous rosette formation of T cells with erythrocytes (Bernard et al, 1988;Aubrit et al, 1989;Gelin et al, 1989). In the studies using monoclonal antibodies (mAbs) against CD99 as stimulatory ligands, engagement of CD99 led to homotypic aggregation and death of thymocytes and Jurkat T cells (Bernard et al, 1995;Bernard et al, 1997;Hahn et al, 1997;Pettersen et al, 2001) and induced up-regulation of T cell receptor (Waclavic et al, 1998) and major histocompatibility complex molecules on the cell surface (Choi et al, 1998;Kim et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

CD99 type II is a determining factor for the differentiation of primitive neuroectodermal cells

Lee

Lee²,

Park³

et al. 2003

Exp Mol Med

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“…24,[31][32][33] Membranous CD99 immunostaining can be positive in other mesenchymal uterine neoplasms including leiomyoma variants and endometrial stromal tumors, lessening its utility as a differential diagnostic marker in this setting. 30 However, it is noteworthy that 24 of 28 UTROSCT (86%) have been CD99-positive (Table 5).…”

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confidence: 99%

Uterine tumors resembling ovarian sex cord tumors are polyphenotypic neoplasms with true sex cord differentiation

2006

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In this study, we present the clinicopathologic features and immunophenotypic characteristics of five cases of uterine tumors resembling ovarian sex cord tumors and three cases of endometrial stromal tumors with sex cord-like elements, with emphasis on immunohistochemical markers of sex cord differentiation. The mean patient age was 42 years (range 19-69 years), and vaginal bleeding was the most common clinical presentation. The tumors were usually polypoid masses arising in the uterine fundus, with a mean tumor size of 6.7 cm. Sex cord patterns in uterine tumors resembling ovarian sex cord tumors, including anastomosing cords, trabeculae, small nests, tubules, and in one case, a striking retiform architecture with Leydig-like cells, comprised from 70 to 100% of the tumor volume. All uterine tumors resembling ovarian sex cord tumors were positive for two or more markers of sex cord differentiation; all five cases showed strong immunoreactivity for calretinin, with coexpression of CD99 (four cases), Melan-A (two cases), and inhibin (two cases). Endometrial stromal tumors with sex cord-like elements were less frequently positive for markers of sex cord differentiation, with each case positive for one marker (calretinin, two cases; CD99, one case). In addition, all eight cases were frequently positive for cytokeratin, CD10, vimentin, estrogen receptor, and progesterone receptor; desmin immunoreactivity, when present, was limited to minor foci of smooth muscle. Overall, the morphologic and immunohistochemical findings in uterine tumors resembling ovarian sex cord tumors strongly support that these unusual uterine tumors are polyphenotypic neoplasms with true sex cord differentiation.

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The E2 antigen, a 32 kd glycoprotein involved in T-cell adhesion processes, is the MIC2 gene product.

Abstract: These findings show that the E2 antigen, a cell surface molecule involved in T cell adhesion processes, is the product of the MIC2 gene, the only pseudoautosomal gene to be described in man.

Cited by 150 publications

References 36 publications

Suppression of KCMF1 by constitutive high CD99 expression is involved in the migratory ability of Ewing's sarcoma cells

Suppression of KCMF1 by constitutive high CD99 expression is involved in the migratory ability of Ewing's sarcoma cells

CD99 type II is a determining factor for the differentiation of primitive neuroectodermal cells

Uterine tumors resembling ovarian sex cord tumors are polyphenotypic neoplasms with true sex cord differentiation

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