The dysregulated Pink1- Drosophila mitochondrial proteome is partially corrected with exercise

Ebanks, Brad; Ingram, Thomas L; Katyal, Gunjan; Ingram, John R.; Moisoi, Nicoleta; Chakrabarti, Lisa

doi:10.18632/aging.203128

Cited by 3 publications

(2 citation statements)

References 78 publications

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“…The proteomics analysis showed that exercise downregulated tropomyosin-1 isoforms 33/34, tropomyosin-2, acyl-coenzyme A dehydrogenase, isocitrate dehydrogenase, enolase, probable isocitrate dehydrogenase [NAD] subunit alpha, glycerol-3-phosphate dehydrogenase [NAD (+)], pyruvate dehydrogenase E1 component subunit beta, aldo-keto reductase isoform C, alcohol dehydrogenase, and CG9992 isoform A in PD drosophila. These molecules might be candidates to develop therapeutic approaches in PD ( Ebanks et al, 2021 ). Exercise can reverse many of the PD-related changes by downregulating the levels of hippocampal proteins functionally associated with energy metabolism (nucleoside diphosphate kinase B, enolase, and triosephosphate isomerase) and synaptic plasticity (α-synuclein, tenascin-R, Ba1-667, brevican and neurocan core protein) in the non-lesioned hemisphere of PD model rats ( Dimatelis et al, 2013 ).…”

Section: Resultsmentioning

confidence: 99%

Multi-omics studies reveal ameliorating effects of physical exercise on neurodegenerative diseases

Guo

Wang²,

Chao³

et al. 2022

Front. Aging Neurosci.

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IntroductionNeurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease, are heavy burdens to global health and economic development worldwide. Mounting evidence suggests that exercise, a type of non-invasive intervention, has a positive impact on the life quality of elderly with neurodegenerative diseases. X-omics are powerful tools for mapping global biochemical changes in disease and treatment.MethodThree major databases were searched related to current studies in exercise intervention on neurodegenerative diseases using omics tools, including metabolomics, metagenomics, genomics, transcriptomics, and proteomics.ResultWe summarized the omics features and potential mechanisms associated with exercise and neurodegenerative diseases in the current studies. Three main mechanisms by which exercise affects neurodegenerative diseases were summed up, including adult neurogenesis, brain-derived neurotrophic factor (BDNF) signaling, and short-chain fatty acids (SCFAs) metabolism.ConclusionOverall, there is compelling evidence that exercise intervention is a feasible way of preventing the onset and alleviating the severity of neurodegenerative diseases. These studies highlight the importance of exercise as a complementary approach to the treatment and intervention of neurodegenerative diseases in addition to traditional treatments. More mechanisms on exercise interventions for neurodegenerative diseases, the specification of exercise prescriptions, and differentiated exercise programs should be explored so that they can actually be applied to the clinic.

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Section: Resultsmentioning

confidence: 99%

Multi-omics studies reveal ameliorating effects of physical exercise on neurodegenerative diseases

Guo

Wang²,

Chao³

et al. 2022

Front. Aging Neurosci.

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“…The genes being assessed are LRRK2, GBA, SNCA, PRKN, PARK 7, PINK1, and VPS35 . The potential importance of this line of research can be understood from a recent study in PINK1-deficient Drosophila melanogaster which showed that exercise caused the organism’s proteomic profile to return towards wild-type levels [ 108 ]. Future DNA analysis beyond these known PD genes in the future may help us to discern the effects of genetic risk factors for progression and response to exercise as well as potentially provide subgroup analyses based on the genetic profiles.…”

Section: Discussionmentioning

confidence: 99%

Study in Parkinson’s disease of exercise phase 3 (SPARX3): study protocol for a randomized controlled trial

Patterson

Joslin²,

Gil³

et al. 2022

Trials

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Background To date, no medication has slowed the progression of Parkinson’s disease (PD). Preclinical, epidemiological, and experimental data on humans all support many benefits of endurance exercise among persons with PD. The key question is whether there is a definitive additional benefit of exercising at high intensity, in terms of slowing disease progression, beyond the well-documented benefit of endurance training on a treadmill for fitness, gait, and functional mobility. This study will determine the efficacy of high-intensity endurance exercise as first-line therapy for persons diagnosed with PD within 3 years, and untreated with symptomatic therapy at baseline. Methods This is a multicenter, randomized, evaluator-blinded study of endurance exercise training. The exercise intervention will be delivered by treadmill at 2 doses over 18 months: moderate intensity (4 days/week for 30 min per session at 60–65% maximum heart rate) and high intensity (4 days/week for 30 min per session at 80–85% maximum heart rate). We will randomize 370 participants and follow them at multiple time points for 24 months. The primary outcome is the Movement Disorders Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) motor score (Part III) with the primary analysis assessing the change in MDS-UPDRS motor score (Part III) over 12 months, or until initiation of symptomatic antiparkinsonian treatment if before 12 months. Secondary outcomes are striatal dopamine transporter binding, 6-min walk distance, number of daily steps, cognitive function, physical fitness, quality of life, time to initiate dopaminergic medication, circulating levels of C-reactive protein (CRP), and brain-derived neurotrophic factor (BDNF). Tertiary outcomes are walking stride length and turning velocity. Discussion SPARX3 is a Phase 3 clinical trial designed to determine the efficacy of high-intensity, endurance treadmill exercise to slow the progression of PD as measured by the MDS-UPDRS motor score. Establishing whether high-intensity endurance treadmill exercise can slow the progression of PD would mark a significant breakthrough in treating PD. It would have a meaningful impact on the quality of life of people with PD, their caregivers and public health. Trial registration ClinicalTrials.govNCT04284436. Registered on February 25, 2020.

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Drosophila exercise, an emerging model bridging the fields of exercise and aging in human

Ding

Li²,

Zheng³

2022

Front. Cell Dev. Biol.

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Exercise is one of the most effective treatments for the diseases of aging. In recent years, a growing number of researchers have used Drosophila melanogaster to study the broad benefits of regular exercise in aging individuals. With the widespread use of Drosophila exercise models and the upgrading of the Drosophila exercise apparatus, we should carefully examine the differential contribution of regular exercise in the aging process to facilitate more detailed quantitative measurements and assessment of the exercise phenotype. In this paper, we review some of the resources available for Drosophila exercise models. The focus is on the impact of regular exercise or exercise adaptation in the aging process in Drosophila and highlights the great potential and current challenges faced by this model in the field of anti-aging research.

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The dysregulated Pink1- Drosophila mitochondrial proteome is partially corrected with exercise

Cited by 3 publications

References 78 publications

Multi-omics studies reveal ameliorating effects of physical exercise on neurodegenerative diseases

Multi-omics studies reveal ameliorating effects of physical exercise on neurodegenerative diseases

Study in Parkinson’s disease of exercise phase 3 (SPARX3): study protocol for a randomized controlled trial

Drosophila exercise, an emerging model bridging the fields of exercise and aging in human

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