The dysplastic nevus syndrome Our definition

De, Elder; Mh, Green; th, Guerry D; Kraemer, Kenneth H.; Wh, Clark

doi:10.1097/00000372-198210000-00014

Cited by 175 publications

(42 citation statements)

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“…[1][2][3][4][5][6][7] Clinically, they are characterized by four major properties ( Figure 1): Their size tends to be greater than that of common nevi but less than that of melanomas; in the most common definition, dysplastic nevi are 5 mm in diameter or greater. Also by definition, dysplastic nevi contain a junctional component, which clinically is macular or flat, sometimes with a 'pebbly' surface.…”

Section: Dysplastic Nevimentioning

confidence: 99%

“…Histologically, dysplastic nevi are characterized by two major categories of criteria: architectural and cytologic 1,3,[3][4][5][6]33 ( Figures 2 and 3). Architecturally, just as is true by definition clinically, dysplastic nevi are larger than common acquired nevi and the diagnosis should be made cautiously in lesions smaller than about 4 mm in diameter on the slide.…”

Section: Dysplastic Nevimentioning

confidence: 99%

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Precursors to melanoma and their mimics: nevi of special sites

2006

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Melanocytic nevi, which are benign tumors of melanocytes, may have occasional cosmetic significance but, for the most part, they are important only in relation to melanoma. Nevi are the most important simulants of melanoma, both clinically and histologically, and can usually be reliably distinguished from melanomas using published criteria. Some lesions are characterized by greater degrees of atypia and may be more difficult to diagnose. Dysplastic nevi are among the most important simulants of melanoma. Nevi may also be important as potential precursors of melanoma; however, most nevi are stable and will not progress to malignancy. Nevi are vastly more common than melanomas and the rate of progression of individual lesions is very low. Therefore, nevi are not as a rule managed by wholesale excision to prevent melanoma. Nevi are also important as risk markers, identifying individuals at greater risk of developing melanoma in the future. Dysplastic nevi and, to a lesser extent, common acquired and congenital nevi are among the most important melanoma risk markers. Nevi of special sites have been identified as nevi that may show atypical features suggestive of a dysplastic nevus or of a melanoma. However, they are not risk markers and they are not malignancies. Nevi of genital skin, acral skin, and flexural skin are among the most important 'nevi of special sites'. It is important, in considering the differential diagnosis of a lesion in a special site, to avoid overcalling such a lesion as a melanoma or a dysplastic nevus because this could lead to excessive treatment. Conversely, it is important to avoid undercalling a lesion that is a dysplastic nevus or a melanoma as a nevus of special sites, because in this circumstance a patient could lose the opportunity either for surveillance to recognize a developing melanoma at an early, curable stage, or for definitive treatment of an established malignancy. In this monograph, dysplastic nevi and nevi of special sites are compared and contrasted in relation to melanoma.

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Section: Dysplastic Nevimentioning

confidence: 99%

Section: Dysplastic Nevimentioning

confidence: 99%

Precursors to melanoma and their mimics: nevi of special sites

2006

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“…Because clinically atypical moles from these family members showed significant evidence ot dysplasia upon pathological evaluation of biopsies, this syndrome has more recently been defined as the dysplastic nevus syndrome (DNS) (Elder et al, 1982). Greene et al (1983) reported results from a segregation analysis of a number of families referred to the NCI because ot a high density of CMM cases.…”

Section: Introductionmentioning

confidence: 99%

Genetic Analysis Workshop 7: Summary of the melanoma workshop

Risch

Sherman²

1992

Cytogenet Genome Res

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“…It is known for many years that a group of nevi in different anatomic sites that may simulate both dysplastic nevi and melanoma [1,6,7,12]. these nevi have been termed generically "nevi of special sites".…”

Section: Discussionmentioning

confidence: 99%

Morphologic analysis of periumbilical nevi

Nicolau¹,

Aşchie²

2013

ARS Medica Tomitana

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A large number of publications recognize that there are melanocytic lesions with microscopic features similar to melanoma, related to their location, with no prognostic importance. those locations are represented by the ear, the milk lines (axillary, breast, periumbilical and inguinal regions), palms, soles and flexural regions. the periumbilical nevi are included by some authors in the category of the flexural nevi. In 2004, Rongioletti et al., performed a study on a number of 101 breast nevi, considering 10 histologic parameters. Starting from rongioletti's study we measured 10 histologic parameters on 121 nevi (26 from the periunmbilical area) and notes with 0 if absent or impossible to evaluate and with 1 if present. the score for each lesion ranged from 0 to 6 and we compared the features of the periumbilical nevi with the nevi from the control sites and found that the ones in the periumbilical area have more frequently atypical features than the nevi from the other sites (lemtiginous proliferation of nevus cells, architectural disorder of the nevus cell nests and stromal reactions as dermal fibroplasias and dermal lymphocytic infiltrate). We also performed immunohistochemical examination on lesions that presented three or more of

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The dysplastic nevus syndrome Our definition

Cited by 175 publications

References 0 publications

Precursors to melanoma and their mimics: nevi of special sites

Precursors to melanoma and their mimics: nevi of special sites

Genetic Analysis Workshop 7: Summary of the melanoma workshop

Morphologic analysis of periumbilical nevi

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