The Dysexecutive Questionnaire Advanced

Bodenburg, Sebastian; Dopslaff, Nina

doi:10.1097/nmd.0b013e31815faa2b

Cited by 59 publications

(27 citation statements)

References 14 publications

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“…Furthermore, DEX has two versions, self- and informant-reported questionnaires. In other studies using DEX, sometimes only the self-reported version (Amieva et al 2003; Bodenburg and Dopslaff 2008; Heffernan et al 2004) and sometimes only the informant-reported version (Chaytor and Schmitter-Edgecombe 2007; Krabbendam et al 1999) was used, yet in other cases both versions were used (Burgess et al 1998; Odhuba et al 2005). Some studies have reported that the informant-reported version correlated better with psychological measures, such as other executive functions, general cognitive functions, and perception, than the self-reported version (Burgess et al 1998; Evans et al 1997).…”

Section: Discussionmentioning

confidence: 99%

Brain structures associated with executive functions during everyday events in a non-clinical sample

et al. 2012

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Executive functions involve control processes such as goal-oriented planning, flexible strategy generation, sustaining set maintenance, self-monitoring, and inhibition. Executive functions during everyday events (EFEEs) are distinct from those measured under laboratory settings; the former can be severely impaired while the latter remain intact. Non-routine everyday problems due to executive dysfunctions affect individual functioning in everyday life and are of great clinical interest. Despite the importance of anatomical bases underlying better EFEEs, such bases have never been investigated among non-clinical samples. Using voxel-based morphometry to measure regional gray matter volume (rGMV) and regional white matter volume (rWMV) and diffusion tensor imaging to determine fractional anisotropy values, we identified the anatomical correlates of better EFEEs using the Dysexecutive Questionnaire in 303 normal young subjects (168 men and 135 women). Better EFEEs were associated with a smaller rGMV in the orbitofrontal cortex (OFC) spread across Brodmann areas (BA) 25, 11, and 12 and larger rWMV in the WM area of OFC adjacent to BA 11. Furthermore, individual EFEEs were positively associated with rWMV in the temporal areas, primarily the inferior longitudinal fasciculus and inferior fronto-occipital fasciculus, the latter of which connects OFC and posterior regions. Thus, our findings suggest that brain structures involving OFC, together with other regions, contribute to the maintenance of effective EFEEs among non-clinical subjects.

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Section: Discussionmentioning

confidence: 99%

Brain structures associated with executive functions during everyday events in a non-clinical sample

et al. 2012

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“…The Dysexecutive Questionnaire (DEX) (42) is a rating tool with participant and surrogate forms, which assesses behaviors mediated by executive functioning such as decision-making, impulsivity, social appropriateness, and planning for the future. Though the psychometric properties of the DEX have been relatively little studied, recent investigations have demonstrated it to be a reliable measure (r = 0.85) (52). …”

Section: Methodsmentioning

confidence: 99%

Cognitive and physical rehabilitation of intensive care unit survivors

Jackson

Ely

Morey

et al. 2012

Critical Care Medicine

254

121

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Background Millions of patients who survive medical and surgical general ICU care every year suffer from newly acquired long-term cognitive impairment and profound physical and functional disabilities. To overcome the current reality in which patients receive inadequate rehabilitation, we devised a multi-faceted, in-home tele-rehabilitation program implemented using social workers and psychology technicians with the goal of improving cognitive and functional outcomes. Methods This was a single-site, feasibility, pilot randomized trial of 21 general medical/surgical ICU survivors (8 controls and 13 intervention patients) with either cognitive or functional impairment at hospital discharge. After discharge, study controls received usual care (sporadic rehabilitation) while intervention patients received a combination of in-home cognitive, physical, and functional rehabilitation over a 3-month period via a social worker or master's level psychology technician utilizing telemedicine to allow specialized multi-disciplinary treatment. Interventions over 12 weeks included 6 in-person visits for cognitive rehabilitation and 6 televisits for physical/functional rehabilitation. Outcomes were measured at the completion of the rehabilitation program (i.e., at 3 months) with cognitive functioning as the primary outcome. Analyses were conducted using linear regression to examine differences in 3-month outcomes between treatment groups while adjusting for baseline scores. Results Patients tolerated the program with only 1 adverse event (AE) reported. At baseline both groups were well-matched. At 3-month follow-up, intervention group patients demonstrated significantly improved cognitive executive functioning on the widely used and well-normed Tower Test (TOWER) (for planning and strategic thinking) versus controls [13.0 (Interquartile Range, IQR 11.5 to14.0) vs. 7.5 (4.0 to 8.5), adjusted p<0.01]. Intervention group patients also reported better performance (i.e., lower score) on one of the most frequently employed measures of functional status [Functional Activities Questionnaire (FAQ)] at 3 months vs. controls [1.0 (0.0 to 3.0) vs. 8.0 (6.0 to 11.8), adjusted p=0.04]. Conclusions A multi-component rehabilitation program for ICU survivors combining cognitive, physical, and functional training appears feasible and possibly effective in improving cognitive performance and functional outcomes in just 3 months. Future investigations with a larger sample size should be conducted to build on this pilot, feasibility program and to confirm these results as well as to elucidate the elements of rehabilitation contributing most to improved outcomes.

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“… DEX, Dysexecutive Questionnaire [35]; MMSE, Mini-mental State Exam [36]; TUG, Timed Up-and-Go Test [37]; ADL, Activities of Daily Living [11]; FAQ, Functional Activities Questionnaire [38]; EQ-5D, European Quality of Life-5 Dimensions Visual Analog Scale [39]. …”

Section: Figurementioning

confidence: 99%

Feasibility and safety of early combined cognitive and physical therapy for critically ill medical and surgical patients: the Activity and Cognitive Therapy in ICU (ACT-ICU) trial

et al. 2013

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PURPOSE Cognitive impairment after critical illness is common and debilitating. We developed a cognitive therapy program for critically ill patients and assessed the feasibility and safety of administering combined cognitive and physical therapy early during a critical illness. METHODS We randomized 87 medical and surgical ICU patients with respiratory failure and/or shock in a 1:1:2 manner to three groups: usual care, early once-daily physical therapy, or early once-daily physical therapy plus a novel, progressive, twice-daily cognitive therapy protocol. Cognitive therapy included orientation, memory, attention, and problem solving exercises, and other activities. We assessed feasibility outcomes of the early cognitive plus physical therapy intervention. At 3-months, we also assessed cognitive, functional and health-related quality of life outcomes. Data are presented as median [interquartile range] or frequency (%). RESULTS Early cognitive therapy was a delivered to 41/43 (95%) of cognitive plus physical therapy patients on 100% [92–100%] of study days beginning 1.0 [1.0–1.0] day following enrollment. Physical therapy was received by 17/22 (77%) of usual care patients, by 21/22 (95%) of physical therapy only patients and 42/43 (98%) of cognitive plus physical therapy patients on 17% [10–26%], 67% [46–87%] and 75% [59–88%] of study days, respectively. Cognitive, functional and health-related quality of life outcomes did not differ between groups at 3-month follow-up. CONCLUSIONS This pilot study demonstrates that early rehabilitation can be extended beyond physical therapy to include cognitive therapy. Future work to determine optimal patient selection, intensity of treatment and benefits of cognitive therapy in the critically ill is needed.

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The Dysexecutive Questionnaire Advanced

Cited by 59 publications

References 14 publications

Brain structures associated with executive functions during everyday events in a non-clinical sample

Brain structures associated with executive functions during everyday events in a non-clinical sample

Cognitive and physical rehabilitation of intensive care unit survivors

Feasibility and safety of early combined cognitive and physical therapy for critically ill medical and surgical patients: the Activity and Cognitive Therapy in ICU (ACT-ICU) trial

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