The Dynamics of Neurohumoral Mediators of Vasoconstriction and Vasodilation and Troponin I in Patients With Acute Myocardial Infarction Depending on the Degree of Concomitant Obesity

Ryndina, N. G.; Кравчун, Павло Григорович; Yermak, O.; Borovyk, K. M.; Tytova, Ganna; Kozhyn, M. I.

doi:10.36740/wlek202009208

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…The baseline levels and/ or the time course of these two markers are influenced by the BMI [16]. Other markers that demonstrate adverse relation to high BMI in acute myocardial infarction were the high activity of copeptin and MRproADM [17]. On the other hand, myocardial infarction occurring in the underweight group was found to be an independent predictor of sudden cardiac death [18].…”

Section: Discussionmentioning

confidence: 99%

Correlation Between Different Parameters of Acute Myocardial Infarction and Obesity

Alqahtani¹,

Omeish²,

Ghulam³

et al. 2022

Cureus

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Objective: To study if obesity had a detrimental effect on troponin after acute coronary syndrome. We investigated the effects of the body mass index (BMI) in post-myocardial infarction (MI) patients, and see the difference in troponin levels and other parameters between normal and overweight patients.Methodology: A retrospective cohort study was conducted. Data were extracted from the electronic medical files of patients hospitalized due to acute ST-elevation MI to examine the association between BMI and MI. Sixty-one patients were categorized into normal BMI category, overweight, and obese/morbid obesity groups using the baseline measurements, to assess the independent factors associated with a patient with a high BMI who had a MI.Results: In total, 61 post-myocardial infarction patients with a mean age of 56.9 ± 11.2 years were included in the study. The average BMI was 28.5 ± 6.5 kg/m 2 . Just more than a third (37.4%, n=23) were in the normal BMI category, 19 (31.2%) overweight, and 19 (31.2%) obese/morbid obesity. The mean left ventricle mass was 93.74 ± 32.69 gram and the mean left ventricular ejection fraction was 44.02% ± 10.02. A significant difference in the mean level of troponin and mean heart rate between the body mass index groups (normal vs. overweight groups) was noted. A fair correlation was noted between BMI and left ventricle mass. No statistically significant relation could be linked to high BMI with total cholesterol, low-density lipoprotein (LDL), or aspartate transferase/alanine transaminase (AST/ALT) levels.Conclusions: In this pilot study, the group with a high BMI had a statistically significant lower troponin level and higher mean heart rate. Such data need to be considered when assessing a patient's risk. In addition, obese persons with a MI had a higher left ventricle mass.

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Section: Discussionmentioning

confidence: 99%

Correlation Between Different Parameters of Acute Myocardial Infarction and Obesity

Alqahtani¹,

Omeish²,

Ghulam³

et al. 2022

Cureus

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“…Introduction. Coronary heart disease (CHD) is an important problem in practical medicine, as it requires special measures to prevent such a disease with combined syntropic pathology [11]. At the same time, the primary measure is the statistical determination of cases of re-hospitalization of patients to the hospital due to the available risk factors under conditions of polymorbidity.…”

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Assessment of Re-Hospitalization Probability in Patients With Post-Infarction Cardiosclerosis and Comorbid Pathology

Koteliukh

2021

Scientific and practical journal

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Abstract. The aim of our research was to examine the risk factors for re-hospitalization in patients with acute myocardial infarction with concomitant diabetes mellitus (DM) 2 type or obesity. Materials and methods. The research involved examination of 262 patients with post-infarction cardiosclerosis in combination with type 2 DM or obesity. They were divided into groups: Group 1 included 96 patients who were not hospitalized for 12 months; comparison group 2 consisted of 166 patients who were hospitalized to an in-patient department. The average age of the first group was 65.13±1.43 years, the comparison group – 63.47 ± 1.28 years. Patients were divided into 3 groups to assess the value of CTRP 3 in chronic heart failure (CHF): Group 1 included 80 patients with post-infarction cardiosclerosis without type 2 DM or obesity, Group 2 consisted of 74 patients with post-infarction cardiosclerosis with type 2 DM, Group 3 comprised 60 patients with post-infarction cardiosclerosis and obesity. The research included patients who were treated at the State Institution “L.T. Malaya National Institute of Therapy of the National Academy of Medical Sciences of Ukraine” and in the first cardiology department of Kharkiv Clinical Hospital or Rail Transport No.1 of the “Healthcare Center” branch of the Joint Stock Company “Ukrainian Railways”. Determination of cartonectin and adropin levels was performed by enzyme-linked immunosorbent assays using the commercial test system Human CTRP 3 (Aviscera Bioscience Inc, Santa Clara, USA) and Human Adropin (Elabscience Biotechnology, USA). Statistical processing of the obtained data was performed using the statistical software package “IBM SPPS Statistics 27.0” and “GraphPad Prism software version 9.0.2”. For all types of analysis, the differences were considered statistically significant at p <0.05. One-factor analysis of variance was used to characterize the influence of factors on the indicators. The method of discriminant analysis was used to assess the occurrence of re-hospitalization. Results. The research revealed a decrease in CTRP 3 in the progression of CHF in patients with post-infarction cardiosclerosis in the presence and absence of concomitant type 2 DM or obesity. The effect of diastolic blood pressure, CHF, glucose, the presence of type 2 DM and obesity on the content of CTRP 3 and adropin was determined. Cartonectin has been shown to be a risk factor for re-hospitalization. An assessment scale for the likelihood of re-hospitalization in patients with post-infarction cardiosclerosis and concomitant type 2 DM or obesity has been developed. We analyzed clinical cases of re-hospitalization among patients with post-infarction cardiosclerosis in the presence of concomitant pathology. Conclusions: CTRP 3 has been shown to be associated with the progression of CHF in patients with post-infarction cardiosclerosis and comorbid pathology. The results indicate the effect of hypertension, CHF, type 2 DM and obesity on the content of cartonectin and adropin. As a result, it has been shown that cartonectin is a factor influencing the occurrence of re-hospitalization in patients with post-infarction cardiosclerosis in the presence of syntropic pathology. The proposed method allows to assess the likelihood of re-hospitalization in patients with post-infarction cardiosclerosis with comorbid pathology.

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The Dynamics of Neurohumoral Mediators of Vasoconstriction and Vasodilation and Troponin I in Patients With Acute Myocardial Infarction Depending on the Degree of Concomitant Obesity

Cited by 2 publications

References 21 publications

Correlation Between Different Parameters of Acute Myocardial Infarction and Obesity

Correlation Between Different Parameters of Acute Myocardial Infarction and Obesity

Assessment of Re-Hospitalization Probability in Patients With Post-Infarction Cardiosclerosis and Comorbid Pathology

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