The dynamics of Klebsiella pneumoniae drug-resistant profile in a regional burn center: a retrospective study between 2009 and 2018

Abstract

BACKGROUND: The aim is to observe drug-resistant trends of Klebsiella pneumoniae (K.pneumoniae) isolated from Jiangxi burn center in recent 10 years, and to analyze its causes and provide general information on preventive measures. METHODS: All data were collected by Hospital Laboratory Information System (LIS) and electronic cases. SPSS23.0 software was used to analyze bacterial isolation rate and drug-resistant trend . A chi-square test had been adopted to observe drug-resistant difference of K.pneumoniae in ICU ward and non-ICU ward. RESULTS: During 10 years, 593 K.pneumoniae isolates were acquired from the burn center, which mainly from wound secretion, bloodstream, sputum. The resistance rate of K.pneumoniae to many drugs, including 3 or 4 generation cephalosporins, carbapenems, fluoroquinolones, aminoglycosides, and even tegacycline showed an obvious upward trend (P < 0.05) in this period. The isolated K.pneumoniae was mainly concentrated in 1-3 weeks and carbapenem-resistant K.pneumoniae was mostly acquired in later stage after their hospitalization. CONCLUSION: We should pay attention to the increasing trend of K.pneumoniae in the burn center. Some measures should be taken to reduce isolated rate and drug- resistant rate in the future.