“…Low doses of lovastatin in two patients worsened their conditions; plasma creatine kinase and ubiquinone worsened. These conditions are similar to those seen in dogs treated with high doses of lovastatin (84)(85)(86). Lovastatin in doses used clinically reduces mevalonic acid excretion by the kidney only by one-third (87).…”
Section: Potential Biologic Bases For the Observed Relationshipssupporting
“…Low doses of lovastatin in two patients worsened their conditions; plasma creatine kinase and ubiquinone worsened. These conditions are similar to those seen in dogs treated with high doses of lovastatin (84)(85)(86). Lovastatin in doses used clinically reduces mevalonic acid excretion by the kidney only by one-third (87).…”
Section: Potential Biologic Bases For the Observed Relationshipssupporting
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