The dynamics of cortico-thalamo-cortical interactions at the transition from pre-ictal to ictal LFPs in absence epilepsy

Lüttjohann, Annika; Luijtelaar, Gilles van

doi:10.1016/j.nbd.2012.03.023

Cited by 80 publications

(108 citation statements)

References 46 publications

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“…While the presence of a cortical focus might be sufficient for the generation of localized SWD-like discharges, which have sometimes been noted in LFP (local field potential) recordings obtained in the somatosensory cortex of WAG/Rij and GAERS rats (Luttjohann and van Luijtelaar, 2012;Seidenbecher et al, 1998), it is not sufficient for the generation of "full blown", bilaterally synchronous SWDs. Rather, an intact cortico-thalamic network is essential for the generation of bilaterally synchronous SWDs.…”

Section: Brain Regions Of Interestmentioning

confidence: 99%

“…Since TC neurons of the VPM and Po project to the somatosensory cortex, their activity "reactivates" the cortical focus and via these nuclei, provides a reverberation circuit, the cortico-thalamo-cortical network, relevant for SWD generation and maintenance. Recent network analytical studies (Luttjohann et al, 2013;Luttjohann and van Luijtelaar, 2012) demonstrated that the cortex displays a unique coupling profile with each of the above mentioned nuclei and even subparts of the nucleus (i.e. the cortex was found to interact differently with the caudal and rostral part of the NRT) during SWDs and in a short period immediately prior to SWD onset, where the network already seems to prepare towards SWD generation.…”

Section: Brain Regions Of Interestmentioning

confidence: 99%

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Upholding WAG/Rij rats as a model of absence epileptogenesis: Hidden mechanisms and a new theory on seizure development

Russo

Citraro

Constanti³

et al. 2016

Neuroscience & Biobehavioral Reviews

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128

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Upholding WAG/Rij rats as a model of absence epileptogenesis: Hidden mechanisms and a new theory on seizure development.Neuroscience and Biobehavioral Reviews http://dx.doi.org/10. 1016/j.neubiorev.2016.09.017 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractThe WAG/Rij rat model has recently gathered attention as a suitable animal model of absence epileptogenesis. This latter term has a broad definition encompassing any possible cause that determines the development of spontaneous seizures; however, most of, if not all, preclinical knowledge on epileptogenesis is confined to the study of post-brain insult models such as traumatic brain injury or post-status epilepticus models. WAG/Rij rats, but also synapsin 2 knockout, Kv7 current-deficient mice represent the first examples of genetic models where an efficacious antiepileptogenic treatment (ethosuximide) was started before seizure onset. In this review, we have critically reconsidered all articles published regarding WAG/Rij rats, from the perspective that the period before SWD onset is considered as the latent period. In our new theory on seizure development, it is proposed that genes might be considered as the initial "insult" responsible for all plastic changes underpinning the development of spontaneous seizures. According to this idea, in WAG/Rij rats, genetic predisposition would lead to the development of abnormal bilateral cortical epileptic foci, which would then nongenetically stimulate the rest of the brain to rearrange networks in order to phenotypically develop seizures similarly to what happens during electrical kindling.

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Section: Brain Regions Of Interestmentioning

confidence: 99%

Section: Brain Regions Of Interestmentioning

confidence: 99%

Upholding WAG/Rij rats as a model of absence epileptogenesis: Hidden mechanisms and a new theory on seizure development

Russo

Citraro

Constanti³

et al. 2016

Neuroscience & Biobehavioral Reviews

Self Cite

128

View full text Add to dashboard Cite

show abstract

“…A self-constructed electrode system was manufactured for multi-site local field potential recordings at specified brain locations [126,217]. It consisted of a 8.5 mm × 4 mm, 3 mm thick Teflon block, which contained small holes located at the relative anterior/posterior (A/P) and medial/lateral (M/L) coordinates of the electrode target structures as determined by the rat-brain atlas of Paxinos and Watson [164].…”

Section: Construction Of An Electrode System Suited For Multi-site Lfmentioning

confidence: 99%

Neural network dynamics in Parkinson's disease

Lourens¹

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“…1) [95]. As these circuits seem to play a role in seizure generation and propagation [18,28,29,96], CMT has been explored as a potential target for DBS therapy. However, it is important to note that CMT also has strong projections to the striatum, and some of its effects, at least in part, may be mediated via the corticostriato-thalamic circuit [97].…”

Section: Centromedian Nucleus Of the Thalamusmentioning

confidence: 99%

“…Cortico-thalamo-cortical excitatory loops appear to be involved in absence epilepsy [28] and motor cortex seizures [18]. In a nonhuman primate model of chronic focal motor seizures, thalamotomy restricted to the anterior part of the ventro-postero-lateral nucleus was able to produce longlasting benefit and in most cases led to nearly complete seizure suppression [29].…”

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confidence: 99%

Deep Brain Stimulation for the Treatment of Epilepsy: Circuits, Targets, and Trials

2014

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Deep brain stimulation (DBS) has proven remarkably safe and effective in the treatment of movement disorders. As a result, it is being increasingly applied to a range of neurologic and psychiatric disorders, including medically refractory epilepsy. This review will examine the use of DBS in epilepsy, including known targets, mechanisms of neuromodulation and seizure control, published clinical evidence, and novel technologies. Cortical and deep neuromodulation for epilepsy has a long experimental history, but only recently have better understanding of epileptogenic networks, precise stereotactic techniques, and rigorous trial design combined to improve the quality of available evidence and make DBS a viable treatment option. Nonetheless, underlying mechanisms, anatomical targets, and stimulation parameters remain areas of active investigation.

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The dynamics of cortico-thalamo-cortical interactions at the transition from pre-ictal to ictal LFPs in absence epilepsy

Cited by 80 publications

References 46 publications

Upholding WAG/Rij rats as a model of absence epileptogenesis: Hidden mechanisms and a new theory on seizure development

Upholding WAG/Rij rats as a model of absence epileptogenesis: Hidden mechanisms and a new theory on seizure development

Neural network dynamics in Parkinson's disease

Deep Brain Stimulation for the Treatment of Epilepsy: Circuits, Targets, and Trials

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