The Dynamic Response of Intraocular Pressure and Ocular Pulse Amplitude to Acute Hemodynamic Changes in Normal and Glaucomatous Eyes

Li, J.; Gupta, Vivek; You, Yuyi; Ng, Keith; Graham, Stuart L.

doi:10.1167/iovs.13-12405

Cited by 10 publications

(7 citation statements)

References 47 publications

(52 reference statements)

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“…(2) Only a single intervention is needed to produce a sustained IOP elevation. Taken these two points together, some IOP models require multiple injections of foreign agents into the anterior chamber 47 or a single injection of hypertonic saline into aqueous drainage veins. 48 Laser models involve photocoagulation of the trabecular meshwork 49 and other models require cauterization of the episcleral veins.…”

Section: Discussionmentioning

confidence: 99%

A Mouse Model of Chronic Ocular Hypertension Induced by Circumlimbal Suture

Liu

Flanagan

2017

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To develop a chronic ocular hypertension mouse model by inducing intraocular pressure (IOP) elevation using a suture technique previously developed for rats.METHODS. C57BL/6 mice were given monocular circumlimbal suture (10/0) placement under anesthesia (ketamine/xylazine). The suture was left in place for 12 weeks (n ¼ 10). A control group had the same treatment while it was removed after day 1 (n ¼ 10). Intraocular pressure, electroretinogram (ERG), and optical coherence tomography (OCT) were measured in both groups for 12 weeks. At week 12, animals were euthanized and retina was harvested for histologic assessment.RESULTS. In the group with extended suture placement, IOP spiked from 14.3 6 0.9 to 48.4 6 4.8 mm Hg immediately after suture implantation. At day 1, it declined to 33.2 6 3.7 mm Hg and remained elevated for 12 weeks. In the suture removal group, IOP normalized to baseline within a day following suture removal. In the group with prolonged IOP elevation, the retinal ganglion cell (RGC) mediated ERG responses continued to exacerbate and were significantly reduced by week 12 (P < 0.001). Progressive loss of retinal nerve fiber layer was found and it became significant from week 4 (P < 0.001). At week 12, significant loss of RGCs (P < 0.001) was noted. In the IOP normalization group, no alteration in ERG, OCT, and RGC counting was observed.CONCLUSIONS. The circumlimbal suture approach produces a mild chronic IOP elevation in mice. Functional and structural changes under model induction are largely independent of the initial IOP spike.Keywords: glaucoma, intraocular pressure, electroretinogram, optical coherence tomography, ganglion cell G laucoma is a chronic ocular disease, which is characterized by selective retinal ganglion cell (RGC) degeneration and progressive visual field loss. Elevated intraocular pressure (IOP) is a critical risk factor for disease development, and IOP lowering is the mainstay of disease management. [1][2][3] Over the past few decades, a variety of rodent models have been developed to simulate human glaucoma. [4][5][6][7] These models aim to induce either acute or chronic ocular hypertension leading to glaucomatous-like changes. By using such models, investigators have made significant insights into understanding the pathogenesis of the disease.Previously, a rat model of chronic IOP elevation using conjunctival circumlimbal suture was developed. 8,9 This minimally invasive technique employed the concept of oculopression to produce elevated IOP. [10][11][12] An advantage of the suture compression model is that it is not associated with ocular tissue penetration or traumatization, and therefore relatively preserves the immune privilege of the eye. It was reported that a mild, chronic IOP elevation was induced for at least 15 weeks following an initial IOP spike that appeared immediately after suture placement. Progressive loss of RGC function, retinal nerve fiber layer (RNFL) defect, and eventual cell death in the ganglion cell layer were observed under model induction, ...

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Section: Discussionmentioning

confidence: 99%

A Mouse Model of Chronic Ocular Hypertension Induced by Circumlimbal Suture

Liu

Flanagan

2017

Invest. Ophthalmol. Vis. Sci.

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“…Li JC et al. showed the correlation between intraocular pressure and ocular pulse amplitude to acute hemodynamic changes in normal and glaucomatous eyes. There is also a significant group of papers on corneal deformation, but deformations with a frequency above 100 Hz were not taken into account, for example, Leung et al .…”

Section: Critical Summarymentioning

confidence: 99%

Scheimpflug camera in the quantitative assessment of reproducibility of high‐speed corneal deformation during intraocular pressure measurement

Koprowski

Ambrósio²,

Reisdorf

2015

Journal of Biophotonics

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The paper presents an original analysis method of corneal deformation images from the ultra-high-speed Scheimpflug camera (Corvis ST tonometer). Particular attention was paid to deformation frequencies exceeding 100 Hz and their reproducibility in healthy subjects examined repeatedly. A total of 4200 images with a resolution of 200 × 576 pixels were recorded. The data derived from 3 consecutive measurements from 10 volunteers with normal corneas. A new image analysis algorithm, written in Matlab with the use of the Image Processing package, adaptive image filtering, morphological analysis methods and fast Fourier transform, was proposed. The following results were obtained: (1) reproducibility of the eyeball reaction in healthy subjects with precision of 10%, (2) corneal vibrations with a frequency of 369 ± 65 Hz (3) and amplitude of 7.86 ± 1.28 µm, (4) the phase shift within two parts of the cornea of the same subject of about 150°. The result of image sequence analysis for one subject and deformations with a corneal frequency response above 100 Hz.

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“…Li et al 15 evaluated the effects of acute arterial blood pressure (ABP) and venous pressure changes on IOP in rats with experimental glaucoma and revealed that increased venous pressure resulted in a sustained rise in IOP. For this reason, we assessed the effects of increased INP on the human eye.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Intranasal Pressure on Intraocular Pressure

Kumral¹,

Erden²,

Erçalık³

et al. 2017

Ophthalmol Open J

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Brief Research ReportABSTRACT Purpose: The aim of this study was to evaluate intraocular pressure (IOP) after the application of the nasal packing for sinonasal surgery. Methods: A total of 40 patients who underwent sinonasal surgery were enrolled in this prospective study. Patients were randomly assigned into two groups: gauze packing (group 1) and silicone nasal septal splint (group 2). All participants completed a comprehensive questionnaire and underwent an ocular examination including measurement of IOP by Goldmann applanation tonometry (GAT). All the measurements were repeated before removing the nasal packings. IOP measurements before the operation and during the nasal packing were compared with each other. Results:The study group comprised 21 males (52.5 %) and 19 females (47.5%). The mean age was 29.10±8.18 years (median 27.50) (min-max=18-51). Twenty-three (57.5%) had silicone nasal packing while 17 (42.5%) had gauze nasal packing. Mean nasal packing duration was 2.575±0.712 days. The post-operative increase in the intraocular pressure of the both eyes were not statistically significant (p>0.05). IOPs of the patients' eyes showed no significant increase, compared to the pre-operative results according to the type of nasal packing used (p>0.05). Conclusions: Increased intranasal pressure due to nasal packing did not increase intraocular pressure. The type of the nasal packing also did not differ to increase the intraocular pressure.

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The Dynamic Response of Intraocular Pressure and Ocular Pulse Amplitude to Acute Hemodynamic Changes in Normal and Glaucomatous Eyes

Cited by 10 publications

References 47 publications

A Mouse Model of Chronic Ocular Hypertension Induced by Circumlimbal Suture

A Mouse Model of Chronic Ocular Hypertension Induced by Circumlimbal Suture

Scheimpflug camera in the quantitative assessment of reproducibility of high‐speed corneal deformation during intraocular pressure measurement

The Effect of Intranasal Pressure on Intraocular Pressure

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