The Dynamic Regulation of mRNA Translation and Ribosome Biogenesis During Germ Cell Development and Reproductive Aging

Mercer, Marianne; Jang, Seoyeon; Ni, Chunyang; Buszczak, Michael

doi:10.3389/fcell.2021.710186

Cited by 35 publications

(34 citation statements)

References 266 publications

(302 reference statements)

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“…Ribosomal proteins are overexpressed in breast cancer, liver, and colon [ 19 ]. Increased cell proliferation or development does not immediately increase ribosomal protein mRNA [ 20 ] immediately. In other words, there is valid proof that ribosomal proteins are likely to lead to cell's malignant transformation [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

The Current Status of SSRP1 in Cancer: Tribulation and Road Ahead

Jia

Guo

Wang

et al. 2022

Journal of Healthcare Engineering

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Background and Objectives. Owing to the complexity and heterogeneity of tumors, cancer’s early diagnoses and treatment have become a provocation. Structure-specific recognition protein-1 (SSRP1) is a histone (H3-H4 or H2A-H2B) chaperone in chromatin-related processes such as transcription, cell cycle control, and DNA replication, reported in various tumor tissues. It may also be used as a biomarker. This study aimed to highlight the role of SSRP1 in cancer with a focus on the current progress and future perspective. Methods. We search PubMed and Web of Sciences with keywords “SSRP1” and “Cancer.” Only English literature was included, and conference papers and abstract were all excluded. Results. Transcription factors are classified into three groups based on their DNA binding motifs: simple helix-loop-helix (bHLH), classical zinc fingers (ZF-TFs), and homeodomains. The tumor-suppressive miR-497 (microRNA-497) acted as an undesirable regulator of SSRP1 upregulation, which led to tumor growth. The siRNA (small interfering RNA) knockdown of SSRP1 hindered cell proliferation along with incursion and glioma cell migration. Through the AKT (also known as protein kinase B) signaling pathway, SSRP1 silencing affected cancer apoptosis and cell proliferation. Conclusion. The MAPK (mitogen-activated protein kinase) signaling pathway’s phosphorylation was suppressed when SSRP1 was depleted. The effect of curaxins on p53 and NF-B (nuclear factor-κB), and their toxicity to cancer cells, is attributable to the FACT (facilitates chromatin transcription) complex’s chromatin trapping.

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Section: Introductionmentioning

confidence: 99%

The Current Status of SSRP1 in Cancer: Tribulation and Road Ahead

Jia

Guo

Wang

et al. 2022

Journal of Healthcare Engineering

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“…Glycogen phosphorylase catalyzed glycogen decomposition likely reduced the deleterious effects of glycogen overproduction on germ cells of fertile individuals [51]. BOLL belongs to the DAZ gene family, which is required to establish germ cell identity, regulate germ cell development, and prepare germ cells for entry into meiosis [52]. Our RNA sequencing assay showed that the downregulation of BOLL and its regulatory lncRNA MSTRG.5675.1 might particularly impact the gametogenesis process of oysters.…”

Section: Discussionmentioning

confidence: 87%

Transcription Analysis for Core Networks of lncRNAs–mRNAs: Implication for Potential Role in Sterility of Crassostrea gigas

Liu

2022

Biology

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Long noncoding RNA (lncRNA), a type of non-protein-coding transcript, is emerging as a crucial regulator of gene expression. However, few roles of lncRNA in the reproductive process of the Pacific oyster (Crassostrea gigas) have been defined, especially in the regulatory mechanism of sterile triploids gametogenesis. To uncover the potential role of lncRNA, the gonads of diploids, sterile triploids, and partially sterile triploids underwent RNA sequencing. A total of 9618 reliable lncRNAs were identified. The target relationship between lncRNA and mRNA was predicted based on cis, trans, and antisense regulation with bioinformatic software. We chose differentially expressed lncRNAs and mRNAs when sterile triploids were compared to partially sterile triploids and diploids for subsequent functional enrichment analysis. Findings revealed that trans-regulatory lncRNAs might play a significant role in the gametogenesis of C. gigas. Combining pathway results, we constructed core networks of lncRNAs–mRNAs for triploid sterile females and hermaphrodites. Fifty-four genes related to cell division, germline-cell maintenance, and glycogen metabolism were found to be associated with sterility. A total of 28 candidate lncRNAs were predicted to trans-regulate these genes. We speculated that MSTRG.79882.3 and MSTRG.79882.4 for triploid sterile females and MSTRG.33704.1, MSTRG.63844.1, and MSTRG.5675.1 for hermaphrodites were highly important as they were predicted to regulate more sterility-specific genes than others. Our work collectively identified sterility-related lncRNAs and implicated the potential mechanism of lncRNA-mediated regulation in the gametogenesis of sterile triploid oysters.

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“…This results in discordance between mRNA and protein levels. Similarly, in various species, RA oocytes experience a decline in their ability to carry out mRNA translation [ 43 ]. The elevation in PEDF mRNA in RA GCs could derive from excessive transcription, as feedback to the decline in protein level.…”

Section: Discussionmentioning

confidence: 99%

The Role of PEDF in Reproductive Aging of the Ovary

Nemerovsky

Bar‐Joseph

Eldar‐Boock

et al. 2022

IJMS

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Reproductive aging is characterized by a decline in ovarian function and in oocytes’ quantity and quality. Pigment epithelium-derived factor (PEDF), a pivotal player in ovarian angiogenic and oxidative balance, was evaluated for its involvement in reproductive aging. Our work examines the initial stage of reproductive aging in women and mice, and the involvement of PEDF in the process. Granulosa cells from reproductively-aged (RA) women and mice (36–44 years old and 9–10 months old, respectively) indicated an increase in the level of PEDF mRNA (qPCR), with yet unchanged levels of AMH and FSHR mRNAs. However, the PEDF protein level in individual women showed an intra-cellular decrease (ELISA), along with a decrease in the corresponding follicular fluid, which reflects the secreted fraction of the protein. The in vitro maturation (IVM) rate in the oocytes of RA mice was lower compared with the oocytes of young mice, demonstrated by a reduced polar body extrusion (PBE) rate. The supplementation of PEDF improved the hampered PBE rate, manifested by a higher number of energetically-competent oocytes (ATP concentration and mtDNA copy number of individual oocytes). Our findings propose PEDF as an early marker of reproductive aging, and a possible therapeutic in vitro agent that could enhance the number of good-quality oocytes in older IVF patients.

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The Dynamic Regulation of mRNA Translation and Ribosome Biogenesis During Germ Cell Development and Reproductive Aging

Cited by 35 publications

References 266 publications

The Current Status of SSRP1 in Cancer: Tribulation and Road Ahead

The Current Status of SSRP1 in Cancer: Tribulation and Road Ahead

Transcription Analysis for Core Networks of lncRNAs–mRNAs: Implication for Potential Role in Sterility of Crassostrea gigas

The Role of PEDF in Reproductive Aging of the Ovary

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