2022
DOI: 10.1016/j.jpha.2022.05.005
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The dynamic metabolic profile of Qi-Yu-San-Long decoction in rat urine using UPLC-QTOF-MSE coupled with a post-targeted screening strategy

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Cited by 5 publications
(4 citation statements)
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“…Nevertheless, it is important to note that the metabolites found in feces and urine differed significantly, primarily due to variations in the physicochemical properties of the compounds themselves and the intricate in vivo metabolic processes involved. Furthermore, it should be noted that certain compounds in urine underwent phase I metabolic reactions prior to the phase II binding reactions, as evidenced by previously identified urine metabolites (Zheng et al, 2022). By contrast, fecal metabolites often resulted directly from either phase I or phase II metabolism.…”
Section: Discussionmentioning
confidence: 88%
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“…Nevertheless, it is important to note that the metabolites found in feces and urine differed significantly, primarily due to variations in the physicochemical properties of the compounds themselves and the intricate in vivo metabolic processes involved. Furthermore, it should be noted that certain compounds in urine underwent phase I metabolic reactions prior to the phase II binding reactions, as evidenced by previously identified urine metabolites (Zheng et al, 2022). By contrast, fecal metabolites often resulted directly from either phase I or phase II metabolism.…”
Section: Discussionmentioning
confidence: 88%
“…All ingredients in the QYSLD recipe were weighed according to the prescription with a total of 10 ingredients, including Astragali Radix (30 g), Hedyotis diffusa Willd (20 g), S. nigrum L. (20 g), Coicis semen (20 g), Polygonati Odorati Rhizoma (10 g), Curcumae Rhizoma (10 g), Scolopendra (6 g), Pheretima (6 g), E. helioscopia L. (6 g) and Fritillariae Cirrhosae Bulbus (6 g). The preparation of QYSLD samples follows the same method as described in previous articles published by our research group (Huang et al, 2021; Zheng et al, 2022).…”
Section: Methodsmentioning
confidence: 99%
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