The dynamic interactions between chemotherapy drugs and plasmid DNA investigated by atomic force microscopy

Li, Mi; Liu, Lianqing; Xiao, Xiubin; Xi, Ning; Wang, Yuechao

doi:10.1007/s40843-016-5152-2

Cited by 10 publications

(2 citation statements)

References 45 publications

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“…This reduction in binding probability was comparable to the results obtained with the TGF-β1 antibody treatment (6.4 ± 1.9%). Additionally, Li et al [139] explored the nanoscale interactions between plasmid DNAs and drugs (methotrexate and cisplatin) and demonstrated significant alterations in the geometric characteristics of the plasmid DNAs upon drug stimulation. Moreover, Yun et al [140] investigated the biomechanical properties of HeLa cells before and after treatment with docetaxel.…”

Section: Investigating Binding Mechanismsmentioning

confidence: 99%

Atomic Force Microscopy as a Tool to Study Transport Phenomena in Biological Systems

Kandapal

2023

Processes

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Biological interactions often involve the transport of molecules, ions, or other species across biological membranes or between interacting proteins. The understanding of these transport phenomena is crucial for the development of therapies for various diseases. Atomic force microscopy is a powerful tool that has been increasingly used to study biological systems at the nano scale. The high resolution, quantitative measurements, and the ability to probe biological interactions under near-physiological conditions make AFM an attractive tool for investigating transport phenomena in biological systems. In this article, we focus on the use of AFM in the study of the transport phenomena in biological systems. We discuss the principles of AFM, its instrumentation, and its application in the study of biomolecules and biological systems. We also provide a comprehensive overview of recent articles that have utilized AFM in the study of biomarkers in biological systems.

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Section: Investigating Binding Mechanismsmentioning

confidence: 99%

Atomic Force Microscopy as a Tool to Study Transport Phenomena in Biological Systems

Kandapal

2023

Processes

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“…164 In 1994, Zlatanova et al 165 used AFM to investigate chromatin structures. Chromatin was prepared from chicken erythrocytes and fixed by glutaraldehyde, which was then deposited on 172 showing that the stimulation of chemotherapy drugs resulted in significant changes in both morphology and geometry of DNA. Based on the DNA origami scaffold, DNA activities can be precisely observed.…”

Section: Nucleusmentioning

confidence: 99%

Nanoscale imaging and force probing of biomolecular systems using atomic force microscopy: from single molecules to living cells

Dang

et al. 2017

Nanoscale

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Due to the lack of adequate tools for observation, native molecular behaviors at the nanoscale have been poorly understood. The advent of atomic force microscopy (AFM) provides an exciting instrument for investigating physiological processes on individual living cells with molecular resolution, which attracts the attention of worldwide researchers. In the past few decades, AFM has been widely utilized to investigate molecular activities on diverse biological interfaces, and the performances and functions of AFM have also been continuously improved, greatly improving our understanding of the behaviors of single molecules in action and demonstrating the important role of AFM in addressing biological issues with unprecedented spatiotemporal resolution. In this article, we review the related techniques and recent progress about applying AFM to characterize biomolecular systems in situ from single molecules to living cells. The challenges and future directions are also discussed.

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In Situ Evaluation of Anticancer Monoclonal Antibody Nivolumab‐DNA Interaction Using a DNA‐Electrochemical Biosensor

2019

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The cancer treatment based on monoclonal antibodies has become one of the most successful therapeutic strategies. Among the monoclonal antibodies, nivolumab (NIVO) stands out as being a relatively new anticancer drug. The NIVO‐dsDNA interaction was evaluated, in incubated solutions, by differential pulse voltammetry, UV‐Visible spectrophotometry and gel electrophoresis, and in situ with dsDNA‐, poly[G]‐ or poly[A]‐electrochemical biosensors, by differential pulse voltammetry, electrochemical impedance spectroscopy, and quartz crystal microbalance. The interfacial behaviour of the dsDNA‐electrochemical biosensor was also investigated by cyclic voltammetry and electrochemical impedance spectroscopy. The NIVO‐dsDNA interaction mechanism caused, for shorter times, the binding of the NIVO to DNA, resulting in a NIVO‐dsDNA complex, and for longer times, the relaxation/unwinding of this complex structure. The monoclonal antibody NIVO did not promote oxidative damage to DNA.

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The dynamic interactions between chemotherapy drugs and plasmid DNA investigated by atomic force microscopy

Cited by 10 publications

References 45 publications

Atomic Force Microscopy as a Tool to Study Transport Phenomena in Biological Systems

Atomic Force Microscopy as a Tool to Study Transport Phenomena in Biological Systems

Nanoscale imaging and force probing of biomolecular systems using atomic force microscopy: from single molecules to living cells

In Situ Evaluation of Anticancer Monoclonal Antibody Nivolumab‐DNA Interaction Using a DNA‐Electrochemical Biosensor

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