The Dynamic Face of HIV-1 Subtypes Among Men who have Sex with Men in Beijing, China

Wang, Wanhai; Xu, Jianqing; Jiang, Shulin; Yang, Kai; Meng, Zhefeng; Ma, Yan; Li, Mingkui; Zhang, Xiaoxi; Shao, Yiming; Zhang, Fengmin; Zhang, Xiaoyan

doi:10.2174/157016211795569096

Cited by 39 publications

(40 citation statements)

References 10 publications

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“…The CRF01_AE regions for both URFs were from the CRF01_AE cluster 4 lineage 11 ( Supplementary Fig. S1 16 Overall, cocirculation of CRF01_AE and subtype B among MSM is likely to facilitate the generation of different unique recombinant forms of CRF01_AE and subtype B, as reported here in two novel URFs.…”

Section: Fig 3 Genetic Map Of Bjmp3037b (A) and Bjmp3194b (B)mentioning

confidence: 52%

Genomic Characterization of Two Novel HIV-1 Unique (CRF01_AE/B) Recombinant Forms Among Men Who Have Sex with Men in Beijing, China

Feng

et al. 2015

AIDS Research and Human Retroviruses

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We report here two novel HIV-1 recombinant forms (CRF01_AE/B) isolated from two HIV-positive male subjects infected through homosexual contact in Beijing, China. Recombination contributes substantially to the genetic diversity of HIV-1, and is likely to occur in populations in which multiple subtypes circulate. Molecular epidemiological studies showed that subtype B, CRF01_AE, and CRF07_BC are currently cocirculating in parallel among men who have sex with men (MSM) in China, providing the opportunity for the emergence of new recombinants. Phylogenetic analysis of near full-length genome (NFLG) sequences showed that the unique recombinant forms (URFs) were composed of gene regions from CRF01_AE and subtype B. The CRF01_AE region of the recombinants clustered together with a previously described cluster 4 lineage of CRF01_AE. The B regions of both the recombinants clustered within the B strains. The two recombinants were quite similar with six breakpoints in common. These data highlight the importance of continuous surveillance of the dynamic change of HIV-1 subtypes and new recombinants among the MSM population.

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Section: Fig 3 Genetic Map Of Bjmp3037b (A) and Bjmp3194b (B)mentioning

confidence: 52%

Genomic Characterization of Two Novel HIV-1 Unique (CRF01_AE/B) Recombinant Forms Among Men Who Have Sex with Men in Beijing, China

Feng

et al. 2015

AIDS Research and Human Retroviruses

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“…Recently, however, MSM is the risk group associated with the most rapid increases in HIV infections within China, and studies note HIV-1 strains of different subtypes and CRFs. [38][39][40][41][42] In cities in northern China CRF01_AE infection in MSM is more common than subtype B, 24,[43][44][45] with similar trends in Beijing, Fujian, Guizho, Guandong, Guanxi, Hebei, Hong Kong, Hunan, Jiangsu, Jianxi, Shanghai, and Yunnan. CRF07_BC has recently been identified in young MSM and in some cities exceeds the prevalence of CRF01_AE infection (unpublished data).…”

Section: Hiv-1 Molecular Epidemiologymentioning

confidence: 92%

HIV Epidemic in Asia: Implications for HIV Vaccine and Other Prevention Trials

Phanuphak

Shao³

et al. 2015

AIDS Research and Human Retroviruses

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An overall decrease of HIV prevalence is now observed in several key Asian countries due to effective prevention programs. The decrease in HIV prevalence and incidence may further improve with the scale-up of combination prevention interventions. The implementation of future prevention trials then faces important challenges. The opportunity to identify heterosexual populations at high risk such as female sex workers may rapidly wane. With unabating HIV epidemics among men who have sex with men (MSM) and transgender (TG) populations, an effective vaccine would likely be the only option to turn the epidemic. It is more likely that efficacy trials will occur among MSM and TG because their higher HIV incidence permits smaller and less costly trials. The constantly evolving patterns of HIV-1 diversity in the region suggest close monitoring of the molecular HIV epidemic in potential target populations for HIV vaccine efficacy trials. CRF01_AE remains predominant in southeast Asian countries and MSM populations in China. This relatively steady pattern is conducive to regional efficacy trials, and as efficacy warrants, to regional licensure. While vaccines inducing nonneutralizing antibodies have promise against HIV acquisition, vaccines designed to induce broadly neutralizing antibodies and cell-mediated immune responses of greater breadth and depth in the mucosal compartments should be considered for testing in MSM and TG. The rationale and design of efficacy trials of combination prevention modalities such as HIV vaccine and preexposure prophylaxis (PrEP) remain hypothetical, require high adherence to PrEP, are more costly, and present new regulatory challenges. The prioritization of prevention interventions should be driven by the HIV epidemic and decided by the country-specific health and regulatory authorities. Modeling the impact and cost-benefit may help this decision process.

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“…Reports about China in recent years showed that multiple HIV-1 subtypes, including subtype B, CRF01_AE, and CRF07_BC, were coepidemic in the population of MSM (18,32,33). CRF01_AE, which was the dominant strain in the sexual-risk population (34), seems to have played a more and more important role within the population of MSM.…”

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confidence: 99%

“…CRF01_AE, which was the dominant strain in the sexual-risk population (34), seems to have played a more and more important role within the population of MSM. The percentage of CRF01_AE has been increasing recently and has exceeded that of subtype B, the previously dominant strain, in different cities (10,14,18,31,32). In addition, Chen et al reported that the time of the epidemic of the most recent common ancestor (tMRCA) of CRF01_AE in Hong Kong was in the mid1990s (3).…”

mentioning

confidence: 99%

“…The predominant role of CRF01_AE in Liaoning was consistent with but more distinct than the increasing trend of CRF01_AE virus transmission among MSM in other regions around China. For instance, among Beijing MSM, the proportion of CRF01_AE increased from 3.7% in 2005 to more than 50% in 2009, whereas the proportion of subtype B decreased from more than 90% to less than 20% over the same period (9,32). Similarly, a study of Shijiazhuang MSM showed that CRF01_AE accounted for 52.9% of infections (35.3% for subtype B) between 2008 and 2009 (18).…”

mentioning

confidence: 99%

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Reconstituting the Epidemic History of HIV Strain CRF01_AE among Men Who Have Sex with Men (MSM) in Liaoning, Northeastern China: Implications for the Expanding Epidemic among MSM in China

Han

et al. 2012

J Virol

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dHIV CRF01_AE accounted for 84% of the recent infections among men who have sex with men (MSM) in Liaoning Province of northeastern China. CRF01_AE strains were grouped into two distinct clusters (designated clusters 1 and 2) that were also detected in other regions in China. Phylodynamics study revealed that these two CRF01_AE strains were independently introduced into the population of MSM in China in the early and mid-1990s. Our study elucidated unique features of dynamics and interrelationships of MSM epidemics in China.

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The Dynamic Face of HIV-1 Subtypes Among Men who have Sex with Men in Beijing, China

Cited by 39 publications

References 10 publications

Genomic Characterization of Two Novel HIV-1 Unique (CRF01_AE/B) Recombinant Forms Among Men Who Have Sex with Men in Beijing, China

Genomic Characterization of Two Novel HIV-1 Unique (CRF01_AE/B) Recombinant Forms Among Men Who Have Sex with Men in Beijing, China

HIV Epidemic in Asia: Implications for HIV Vaccine and Other Prevention Trials

Reconstituting the Epidemic History of HIV Strain CRF01_AE among Men Who Have Sex with Men (MSM) in Liaoning, Northeastern China: Implications for the Expanding Epidemic among MSM in China

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