When two macromolecules come very near in a fluid, the molecules that surround them, having finite volume, are less likely to get in between. This leads to a pressure difference manifesting as an entropic attraction, called depletion force. Here we calculate the density profile of liquid molecules surrounding a disordered linear macromolecule, and analytically determine the position dependence of the depletion force between two such molecules. We then verify our formulas with realistic molecular dynamics simulations. Our result can be regarded as an extension of the classical Asakura-Oosawa formula.Objects immersed or dissolved in a liquid will experience an emergent attractive force, as the liquid molecules, having finite volume, cannot squeeze between them [1]. Put another way, it is entropically favorable for the objects to be close, since each have surrounding volumes unavailable to the liquid molecules; and when objects approach to the extent that these volumes overlap, the molecules have more volume to explore [2,3]. Thus objects are more likely to be near each other, as if they attract. This entropic force is called "depletion".Since the seminal papers of Asakura and Oosawa, depletion forces has had far reaching implications from molecular physics [4][5][6][7][8] and biochemistry [9][10][11], to high energy physics [12][13][14][15][16]. It has even been suggested that gravity [17][18][19][20] and the Coulomb force [21] might stem from depletion. So far, depletion forces between plates immersed in rods [22,23] or spherocylinders [24], forces between colloids [25], semiflexible chains [26], spherocylinders [27], and ellipsoids [28,29] immersed in colloids, and forces between colloids immersed in polymer [30] have been established. Forces mediated by mixtures of two types of particles have also been studied [31].While depletion forces always originate from disordered arrangements of a solvent, the objects experiencing the force themselves have always been chosen by authors to be orderly geometric shapes, such as planes, cylinders and spheres. In this work, we study for the first time, the depletion forces between two disordered objects. We analytically derive the depletion force between two linear disordered macromolecules.Specifically, we first solve for the depleted liquid density profile surrounding a disordered granular chain, then calculate the free energy and associated entropic force between two such chains, and lastly, we verify both results with realistic molecular dynamics simulations.A granular chain is a linear arrangement of hard spheres [32], similar to a necklace. Their equilibrium [33-35] transport [36-42] and diffusion [43] properties provide insights into the physics of polymers [44] and biological macromolecules [45,46]. Decoration and tapering [47,48], interfaces [49,50], impurities [51][52][53], disorder and quasiperiodicity [51][52][53][54] are also of interest.