Vigorously developing high-tech industry has been considered to be an effective way to coordinate economic growth with excessive carbon dioxide (CO 2) emissions. However, previous studies have not explored the heterogeneous impacts of hightech industry on CO 2 emissions in regions with different levels of high-tech industry development, and not distinguished the direct and indirect impacts. Based on STIRPAT model, this study investigates the impacts of high-tech industry development on CO 2 emissions in China between 2005 and 2016. Adopting the K-medians cluster method, effects in regions with high, middle, and low levels of high-tech industry development are considered. Indirect effects of high-tech industry development on CO 2 emissions by affecting industry structure upgrades and economic growth are explored. Empirical results illustrate a positive Ushaped nonlinear link between the level of high-tech industry development and CO 2 emissions at the national level and regional (high, middle, and low) level. In terms of indirect impacts, high-tech industry development attenuates the reduction of CO 2 emissions due to industry structure upgrades, and promotes economic growth to increase CO 2 emissions slightly. The indirect impact intensity gradually decreases as the level of high-tech industry development decreases across three regions. Reasonable implications of our findings are proposed. Keywords CO 2 emissions. High-tech industry. STIRPAT model. Heterogeneous effect. Nonlinear relationship Responsible editor: Eyup Dogan