The dynamic changes of cellular immunity among frontline medical workers who supported Wuhan for fighting against the COVID-19

Yang, Juanjuan; Wang, Qian; Zhang, Shuqun; Li, Zongfang; Jiang, Wei

doi:10.1016/j.intimp.2021.108392

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…Some studies indicated that neuropsychological alterations could affect the inflammatory mechanisms, which were related to graft rejection [ 5 ]. Psychological factors were shown to affect the number of immune cells in the peripheral blood [ 6 ].For instance, white blood cell counts and its subsets were increased in patients with psychiatric disorders. The patients with major depressive disorder had higher neutrophils and monocyte counts [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Can Pre-Transplant Psychometric Testing Predict Tacrolimus Intrapatient Variability After Living Kidney Transplantation?

Lee,

Kang

et al. 2024

Psychiatry Investig

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Objective Tacrolimus intrapatient variability (Tac IPV) has been considered a marker for post-graft risk. We investigated pre-transplant psychometric testing to predict Tac IPV after living kidney transplantation.Methods Minnesota Multiphasic Personality Inventory-2 (MMPI-2) examined during pre-transplant evaluation by 102 recipients were analyzed. Subjects were divided into two groups, low IPV (L-IPV) and high IPV (H-IPV), by cutoffs of Tac IPV: median of 24 and value of 30. T-scores of MMPI-2 scales were used to analyze difference between L-IPV and H-IPV using independent t-tests. Stepwise multiple logistic regression was used to test whether MMPI-2 scales affected Tac IPV. Confusion matrix of logistic regression was used to explain statistical power. Cutoff values of significant scales for H-IPV were analyzed by constructing receiver operating characteristic curves.Results Hysteria (Hy) and depression (D) scale scores and Tac IPV were associated in IPV 24 (odds ratio [OR]: 1.08, p<0.01 for Hy; OR: 0.93, p<0.01 for D) and IPV 30 models (OR: 1.09, p<0.01 for Hy; OR: 0.92, p<0.01 for D). Paranoia (Pa) scale scores were associated with Tac IPV in IPV 24 model (OR=1.10, p<0.01) and were significantly higher in H-IPV 24 (p<0.01). F1 scores of confusion matrix in IPV 24 and 30 models were 0.70 and 0.71, respectively. Cutoffs of Hy, D, and Pa scales were 51, 57, and 47, respectively.Conclusion MMPI-2 profile is suggested as a predictor for high Tac IPV after living kidney transplantation.

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Section: Introductionmentioning

confidence: 99%

Can Pre-Transplant Psychometric Testing Predict Tacrolimus Intrapatient Variability After Living Kidney Transplantation?

Lee,

Kang

et al. 2024

Psychiatry Investig

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“…Compared to non-frontline medical workers, frontline healthcare workers appear to experience much more anxiety, stress, and sleeplessness ( 11 , 13 ). Furthermore, an immunological study has revealed that the lymphocyte count and lymphocyte ratio in the peripheral blood of frontline medical workers increased significantly after struggling with COVID-19, but gradually returned to normal several months later ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

Comparison of peripheral blood T, B, and NK lymphocytes between frontline medical workers for treating patients of COVID-19 and normal outpatient and emergency medical workers in China

et al. 2023

Front. Psychiatry

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The outbreak of the novel coronavirus disease 2019 (COVID-19) has led to significant mental stress for frontline medical workers treating patients with confirmed COVID-19 in China. Psychological stress has an impact on the immune system. The number and percentage of lymphocyte subsets are standard indicators of cellular immune detection. Here, we reported the differences in CD3, CD4, CD8, CD19, and CD56 lymphocytes between 158 frontline medical workers and 24 controls from medical staffs of the outpatient and emergency departments. We found that frontline medical workers had significantly lower absolute values and percentages of CD19+ B cells, especially in the female and the aged ≥40 years subgroup. Stratification analysis showed that the absolute values of CD4+ T cells were significantly lower in the aged <40 years subgroup, while percentages of CD8+ T cells were lower and percentages of CD56+ NK cells were higher in the aged ≥40 years subgroup. In summary, this study suggests paying more attention to frontline medical workers’ mental health and immune function, and properly providing them with psychological interventions and measures of care.

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“…Sleep disturbances, as stressors for the body, are associated with immunological dysfunction, which may be involved in the onset and prognosis of psychiatric symptoms (18). Psychological factors were shown to affect the number of immune cells in the peripheral blood (19,20). Many studies have investigated changes in cytokine levels in the peripheral blood of patients with psychiatric disorders (5).…”

Section: Introductionmentioning

confidence: 99%

Association between immune cells in peripheral blood and psychiatric symptoms

Yang,

Wang,

Jiang

2023

Front. Psychiatry

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BackgroundThere are bidirectional associations between immunological dysfunction and psychiatric symptoms. However, the associations between the levels of immune cells in the peripheral blood and psychiatric symptoms remain unclear. The present study aimed to evaluate levels of immune cells in peripheral blood in people with positive psychiatric symptoms.MethodsThis retrospective study analyzed data from routine blood tests and psychopathology and sleep quality assessments. Data were compared between a group of 45 patients with de novo psychological symptoms and 225 matched controls.ResultsPatients with psychiatric symptoms had higher white blood cell and neutrophil counts compared with controls. However, in a subgroup analysis, neutrophil counts were significantly higher than in controls only in patients with multiple psychiatric symptoms. Furthermore, monocyte counts were significantly higher in patients with multiple psychiatric symptoms than in controls. Further, sleep quality was lower in patients with psychiatric symptoms than in controls.ConclusionWhite blood cell and neutrophil counts in the peripheral blood of patients with psychiatric symptoms were significantly higher and sleep quality was significantly lower than in controls. Participants with multiple psychiatric symptoms showed more significant differences in peripheral blood immune cell counts than other subgroups. These results provided evidence for the relationship between psychiatric symptoms, immunity, and sleep.

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The dynamic changes of cellular immunity among frontline medical workers who supported Wuhan for fighting against the COVID-19

Cited by 5 publications

References 35 publications

Can Pre-Transplant Psychometric Testing Predict Tacrolimus Intrapatient Variability After Living Kidney Transplantation?

Can Pre-Transplant Psychometric Testing Predict Tacrolimus Intrapatient Variability After Living Kidney Transplantation?

Comparison of peripheral blood T, B, and NK lymphocytes between frontline medical workers for treating patients of COVID-19 and normal outpatient and emergency medical workers in China

Association between immune cells in peripheral blood and psychiatric symptoms

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