The duration of obesity and the risk of type 2 diabetes

Abstract

Objective: The evidence for the association between obesity and the risk of type 2 diabetes has been derived mainly from the analysis of the degree of obesity. The role of the duration of obesity as an independent risk has not been fully explored. The objective of the present study was to investigate the association between the duration of obesity and the risk of type 2 diabetes. Design: Prospective cohort study. Setting: The Framingham Heart Study (FHS), follow-up from 1948 to 1998. Subjects: A total of 1256 FHS participants who were free from type 2 diabetes at baseline, but were obese on at least two consecutive of the study's twenty-four biennial examinations, were included. Type 2 diabetes status was collected throughout the 48 years of follow-up of the study. The relationship between duration of obesity and type 2 diabetes was analysed using time-dependent Cox models, adjusting for a number of covariates. Results: The unadjusted hazard ratio (HR) for the risk of type 2 diabetes for men was 1?13 (95 % CI 1?09, 1?17) and for women was 1?12 (95 % CI 1?08, 1?16) per additional 2-year increase in the duration of obesity. Adjustment for sociodemographic variables, family history of diabetes, health behaviour and physical activity made little difference to these HR. For women the evidence of a doseresponse relationship was less clear than for men, particularly for women with an older age at obesity onset. Conclusions: The duration of obesity is a relevant risk factor for type 2 diabetes, independent of the degree of BMI.

Impact of BMI on the incidence of metabolic abnormalities in metabolically healthy men

“…Previous studies showed that duration of obesity is an independent risk factor for adverse health outcome. 36,37 Therefore, establishing MHO individuals will require additional studies that observe longer enough and further assess obesity duration and weight history in depth. There are several limitations to this study.…”

Veterans With Diabetes Receive Arthroplasty More Frequently and at a Younger Age

“…Candidate mechanisms include hyperglycemia leading to joint tissue changes, particularly in collagen [27], and obesity leading to (1) increased mechanical load to the joint [31]; and/or (2) nonbiomechanical factors such as metabolism from increased fat [8,14,20,22]. Obesity is a risk factor for diabetes [1,15,17,19,30] and osteoarthritis [8,13,20,22,26], and both factors are increasing rapidly in the US population [6,10]. Unfortunately, data that might further explore these potential hypotheses are unavailable in our data set (BMI, HbA1c, adipokine biomarkers).…”

Obesidade infantil: o problema de saúde pública do século 21

“…Considerando a influência da alimentação dos pais sobre as escolhas das crianças, é fácil perceber que os hábitos alimentares dos pequenos brasileiros estão apoiados sobre os pilares das escolhas inadequadas dos pais. Dessa forma, qualquer intervenção que busque reverter a crescente incidência da obesidade infantil precisa ser trabalhada juntamente com os responsáveis pela aquisição do gênero alimentício: os pais ou responsáveis (7,8) .…”

“…Sobrepeso e obesidade em crianças são o provável início da obesidade na idade adulta e também o início do desenvolvimento de doenças não transmissíveis como diabetes e doença cardiovascular. Sobrepeso e obesidade são doenças crônicas altamente preveníveis, mas a duração da obesidade é um fator de risco, independentemente do IMC na idade adulta (7,8) . Existe risco aumentado em 2,5 de mortalidade a cada duas décadas de obesidade do indivíduo (7) .…”