The Duffy null genotype is associated with a lower level of CCL2, leukocytes and neutrophil count but not with the clinical outcome of HTLV-1 infection

Silva-Malta, Maria Clara Fernandes da; Sales, Camila Campos; Guimarães, Jacqueline Cronemberger; Gonçalves, Poliane de Cássia; Chaves, Daniel Gonçalves; Santos, Hadassa Campos; Pereira, Alexandre da Costa; Ribas, João Gabriel Ramos; Carneiro-Proietti, Anna Bárbara de Freitas; Martins, Marina Lobato

doi:10.1099/jmm.0.000539

Cited by 6 publications

(5 citation statements)

References 46 publications

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“…The same as the other papers published previously, our data in the paper also found that the lymphocyte percentage descend with the disease, which indicates the direct result of viral infection (Dymond, 2018;Qin et al, 2019Qin et al, , 2020Liu Z. et al, 2020). And more interesting, we also found that the higher of white blood cell count and absolute value of neutrophil, the higher risk of severity, which give us a clue that abnormal virus-immune response cross talk in the early stage might affect the outcome of the disease (da Silva-Malta et al, 2017;Abd El-Kader and Al-Jiffri, 2018).…”

Section: Discussionsupporting

confidence: 88%

A Novel Scoring System for Prediction of Disease Severity in COVID-19

Zhang

Qin

et al. 2020

Front. Cell. Infect. Microbiol.

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Background: A novel enveloped RNA beta coronavirus, Corona Virus Disease 2019 (COVID-19) caused severe and even fetal pneumonia in China and other countries from December 2019. Early detection of severe patients with COVID-19 is of great significance to shorten the disease course and reduce mortality.Methods: We assembled a retrospective cohort of 80 patients (including 56 mild and 24 severe) with COVID-19 infection treated at Beijing You'an Hospital. We used univariable and multivariable logistic regression analyses to select the risk factors of severe and even fetal pneumonia and build scoring system for prediction, which was validated later on in a group of 22 COVID-19 patients.Results: Age, white blood cell count, neutrophil, glomerular filtration rate, and myoglobin were selected by multivariate analysis as candidates of scoring system for prediction of disease severity in COVID-19. The scoring system was applied to calculate the predictive value and found that the percentage of ICU admission (20%, 6/30) and ventilation (16.7%, 5/30) in patients with high risk was much higher than those (2%, 1/50; 2%, 1/50) in patients with low risk (p = 0.009; p = 0.026). The AUC of scoring system was 0.906, sensitivity of prediction is 70.8%, and the specificity is 89.3%. According to scoring system, the probability of patients in high risk group developing severe disease was 20.24 times than that in low risk group. Conclusions:The possibility of severity in COVID-19 infection predicted by scoring system could help patients to receiving different therapy strategies at a very early stage.

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Section: Discussionsupporting

confidence: 88%

A Novel Scoring System for Prediction of Disease Severity in COVID-19

Zhang

Qin

et al. 2020

Front. Cell. Infect. Microbiol.

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“…This is common among African and African-Americans and is associated with resistance to malaria infection. 13, 14 Variations in ACKR1 are also associated with a survival advantage in leukopenic HIV patients. 15 The recessive African-specific ACKR1 null allele increases the risk of HIV-1 infection.…”

Section: Introductionmentioning

confidence: 99%

“… 15 The recessive African-specific ACKR1 null allele increases the risk of HIV-1 infection. 14 In the ABO blood group system, individuals with group O blood are more prone to vaso-occlusive crises associated with sickle cell disease (SCD). 16 However, the sickle hemoglobin of SCD combined with the O- blood group also confers some resistance to Plasmodium falciparum infection.…”

Section: Introductionmentioning

confidence: 99%

Using whole-genome sequencing to characterize clinically significant blood groups among healthy older Australians

et al. 2022

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There have been no comprehensive studies of a full range of blood group polymorphisms within the Australian population. The problem is compounded by the absence of any databases carrying genomic information on chronically transfused patients and low frequency blood group antigens in Australia. Here, we use RBCeq, a web server-based blood group genotyping software, to identify unique blood group variants among Australians and compare the variation detected versus global data. Whole genome sequencing data was analysed for 2796 healthy older Australians from the Medical Genome Reference Bank and compared with data from 1000G phase 3 (1KGP3) databases comprising 661 African, 347 American, 503 European, 504 East Asian, and 489 South Asian participants. There were 661 rare variants detected in this Australian sample population, including nine variants that had clinical associations. Notably, we identified 80 variants that were computationally predicted to be novel and deleterious. No clinically significant rare or novel variants were found associated with the genetically complex ABO blood group system. For the Rh blood group system, two novel and 15 rare variants were found. Our detailed blood group profiling results provide a starting point for the creation of an Australian blood group variant database.

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“…The absence of FY glycoprotein genotype is common among Africans and African-Americans, conferring these populations with resistance to malaria infection. 13,14 Variations in ACKR1 are also associated with a survival advantage in leukopenic HIV patients. 15 The recessive African-specific ACKR1 null allele increases the risk of HIV-1 infection.…”

Section: Introductionmentioning

confidence: 99%

“…15 The recessive African-specific ACKR1 null allele increases the risk of HIV-1 infection. 14 In the ABO blood group system, individuals with group O blood type are more prone to vaso-occlusive crises associated with sickle cell disease (SCD). 16 However, the sickle hemoglobin (HbS) of SCD combined with O-type blood group confers some resistance to Plasmodium falciparum infection.…”

Section: Introductionmentioning

confidence: 99%

Using Whole Genome Sequencing to Characterize Clinically Significant Blood Groups Among Healthy Older Australians

Jadhao

Davison

Roulis

et al. 2021

Preprint

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There have been no comprehensive studies of a full range of blood group polymorphisms within the Australian population. The problem is compounded by the absence of any databases carrying genomic information on chronically transfused patients and low frequency blood group antigens in Australia. Here, we use RBCeq, a web server-based blood group genotyping software, to identify unique blood group variants among Australians and compare the variation detected versus global data. Whole genome sequencing data was analysed from for 2796 healthy older Australians from the Medical Genome Reference Bank and compared with data from 1000G phase 3 (1KGP3) databases comprising 661 African, 347 American, 503 European, 504 East Asian, and 489 South Asian participants. There were 688 rare variants detected in this Australian sample population, including nine variants that had clinical associations. Notably, we identified 149 variants that were computationally predicted to be novel and deleterious. No clinically significant rare or novel variants were found associated with the genetically complex ABO blood group system. For the Rh blood group system one novel and 16 rare variants were found. Our detailed blood group profiling results provide a starting point for the creation of an Australian blood group variant database.

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The Duffy null genotype is associated with a lower level of CCL2, leukocytes and neutrophil count but not with the clinical outcome of HTLV-1 infection

Cited by 6 publications

References 46 publications

A Novel Scoring System for Prediction of Disease Severity in COVID-19

A Novel Scoring System for Prediction of Disease Severity in COVID-19

Using whole-genome sequencing to characterize clinically significant blood groups among healthy older Australians

Using Whole Genome Sequencing to Characterize Clinically Significant Blood Groups Among Healthy Older Australians

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