The ducts of carcinomatous breasts, with particular reference to connectivetissue changes

Jackson, J; Orr, John W.

doi:10.1002/path.1700740203

Cited by 45 publications

(12 citation statements)

References 2 publications

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“…Although studies in the 1950s proposed that the desmoplasia represented the condensation of pre-existing collagen [1] there is now good evidence that the collagen is synthesised by myofibroblasts present in the interstitium [2,3]. Several mechanisms that result in myofibroblast activation and collagen synthesis have been proposed.…”

Section: Introductionmentioning

confidence: 99%

The complexities of breast cancer desmoplasia

2001

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The stromal, or 'desmoplastic', responses seen histologically in primary breast carcinomas can vary from being predominantly cellular (fibroblasts/myofibroblasts) with little collagen to being a dense acellular tissue. The mechanisms underlying the stromal response are complex; paracrine activation of myofibroblasts by growth factors is important but the contribution of cytokines/chemokines should not be ignored. A recent xenograft study has proposed that platelet-derived growth factor (PDGF) is the initiator of the desmoplastic response, but this has not been confirmed by (limited) analyses in vivo. Further studies are required to elaborate the mechanisms of the desmoplastic response, to determine its role in breast cancer progression and whether it is the same for all carcinomas.

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Section: Introductionmentioning

confidence: 99%

The complexities of breast cancer desmoplasia

2001

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“…AI-Adnani et al (1975) have alternatively proposed that desmoplasia is the result of an increased amount of newly synthesized collagen directly produced by invasive carcinoma cells themselves. Jackson and Orr (1957) have postulated that this stromal reaction represents a condensation of pre-existing collagen as a result of collapse of mammary tissue.…”

Section: Discussionmentioning

confidence: 99%

“…AI-Adnani et al (1975) have alternatively proposed that desmoplasia is the result of an increased amount of newly synthesized collagen directly produced by invasive carcinoma cells themselves. Jackson and Orr (1957) cells cannot be determined with our technique. Ahmed (1986, 1987) have individualized various types of cells in breast carcinoma stroma: i.e., resting and active fibroblasts, early and mature myofibroblasts which can all be involved in the biosynthesis of type-I collagen.…”

Section: Ish Is a Technique Aimed At Localizing Gene Expressionmentioning

confidence: 92%

Detection by in situ hybridization of messenger RNAs of collagen types I and IV in murine mammary cancer

Doco¹,

Lallemand²,

Laurent³

et al. 1989

Intl Journal of Cancer

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Ten breast carcinomas developing in C3H/Bi female mice were studied by an in situ hybridization technique using cDNA probes encoding alpha-I chains of collagens of types I and IV. The results obtained are compared to histochemical data on antibodies to collagens of types I and IV and ultrastructural observations on these tumors. Immunohistochemistry has revealed the presence of type-IV collagen in basement membranes lining intraductal and well-differentiated cancer nests. Type-I collagen was detected in the stroma surrounding these cells. There was no cellular labelling when these antisera were used. In situ hybridization has shown that type-IV collagen mRNA is detected in non-invasive intraductal and well-differentiated tumor cells and in endothelial cells in the stroma. Good correlation between detection of type-IV collagen lining these cells and evidence of mRNA by in situ hybridization was thus observed. Invasive cancer cells did not express hybridization grains with the type-IV collagen probe. Type-I collagen mRNA was visualized in stromal cells, probably fibroblasts and myofibroblasts as shown by electron microscopy. The most active cells were localized close to non-invasive areas. Our data indicate persistent in-vivo biosynthesis of type-IV collagen by some cancer cells that produce their own limitative environment; they suggest that type-IV collagen is not produced by invasive tumor cells and that stromal cells lining the non-invasive regions have a peculiar behavior.

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“…7 rosing adenosis, and areas of papillary intraductal hyperplasia. Sections made corresponding to the dense zone noted on the specimen radiograph revealed areas of papillary hyperpiasia with central sclerosis.…”

Section: Casementioning

confidence: 98%

Indurative mastopathy: A benign sclerosing lesion of breast with elastosis which may simulate carcinoma

Rickert

Kalisher

Hutter

1981

Cancer

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Five cases of a benign sclerosing lesion of breast are described. The lesion is characterized by a stellate, indurated zone of sclerosis and elastosis in a region of benign ductal proliferation. Because of the stellate configuration and frequently retracted cut surface, the lesion may grossly resemble scirrhous carcinoma. Microscopically, there is often entrapment of benign but distorted ducts at the sclerotic margin, which may further cause confusion with cancer. Of special interest is the radiographic appearance, which may be indistinguishable from scirrhous carcinoma. The term "indurative mastopathy" is a descriptively valid designation for these lesions.

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The ducts of carcinomatous breasts, with particular reference to connectivetissue changes

Cited by 45 publications

References 2 publications

The complexities of breast cancer desmoplasia

The complexities of breast cancer desmoplasia

Detection by in situ hybridization of messenger RNAs of collagen types I and IV in murine mammary cancer

Indurative mastopathy: A benign sclerosing lesion of breast with elastosis which may simulate carcinoma

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