The dual role of LESION SIMULATING DISEASE 1 as a condition‐dependent scaffold protein and transcription regulator

Czarnocka, Weronika; Kelen, Katrien Van Der; Willems, Patrick J.; Szechyńska‐Hebda, Magdalena; Shahnejat-Bushehri, Sara; Balazadeh, Salma; Rusaczonek, Anna; Mueller‐Roeber, Bernd; Breusegem, Frank Van; Karpiński, Stanisław

doi:10.1111/pce.12994

Cited by 39 publications

(52 citation statements)

References 104 publications

(190 reference statements)

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“…However, there could be also another scenario and plant strategy to communicate different stimuli and induce the systemic responses to local stress. In some cases, a cross-talk is seen, in which one type of locally applied stress is capable of generating a protective response or acclimation to another type of biotic or abiotic stress (Mühlenbock et al, 2008 ; Szechyńska-Hebda et al, 2015 , 2016a , b ; Czarnocka et al, 2017 ). The environmental factors, like a sudden increase in light intensity, changes in temperature, limitation in water accessibility, or pathogen attack, all of them depress efficiency of CO 2 assimilation due to reduction of stomatal conductance, but do not limit foliar absorption of light energy (Müller et al, 2001 ; Mullineaux and Karpiński, 2002 ; Holt et al, 2004 ; Baker, 2008 ).…”

Section: Systemic Propagation Of Electrical Signals In Plantsmentioning

confidence: 99%

Electrical Signaling, Photosynthesis and Systemic Acquired Acclimation

2017

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Electrical signaling in higher plants is required for the appropriate intracellular and intercellular communication, stress responses, growth and development. In this review, we have focus on recent findings regarding the electrical signaling, as a major regulator of the systemic acquired acclimation (SAA) and the systemic acquired resistance (SAR). The electric signaling on its own cannot confer the required specificity of information to trigger SAA and SAR, therefore, we have also discussed a number of other mechanisms and signaling systems that can operate in combination with electric signaling. We have emphasized the interrelation between ionic mechanism of electrical activity and regulation of photosynthesis, which is intrinsic to a proper induction of SAA and SAR. In a special way, we have summarized the role of non-photochemical quenching and its regulator PsbS. Further, redox status of the cell, calcium and hydraulic waves, hormonal circuits and stomatal aperture regulation have been considered as components of the signaling. Finally, a model of light-dependent mechanisms of electrical signaling propagation has been presented together with the systemic regulation of light-responsive genes encoding both, ion channels and proteins involved in regulation of their activity. Due to space limitations, we have not addressed many other important aspects of hormonal and ROS signaling, which were presented in a number of recent excellent reviews.

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Section: Systemic Propagation Of Electrical Signals In Plantsmentioning

confidence: 99%

Electrical Signaling, Photosynthesis and Systemic Acquired Acclimation

2017

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“…Moreover, LSD1, EDS1 and PAD4 regulate photosynthesis, water use efficiency (WUE) and seed yield in a condition‐dependent manner, thereby differentiating plant responses in field and laboratory conditions (Wituszyńska et al ). Furthermore, LSD1 is a condition‐dependent scaffold protein and transcription regulator, and forms dimers with EDS1 (Czarnocka et al ). Recently, we reported that PAD4 and EDS1 can function in woody plants in a similar manner as in Arabidopsis (Ślesak et al , Szechyńska‐Hebda et al , Bernacki et al ).…”

Section: Introductionmentioning

confidence: 99%

LSD1‐, EDS1‐ and PAD4‐dependent conditional correlation among salicylic acid, hydrogen peroxide, water use efficiency and seed yield in Arabidopsis thaliana

Bernacki

Czarnocka

Rusaczonek

et al. 2019

Physiologia Plantarum

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In Arabidopsis thaliana, LESION SIMULATING DISEASE 1 (LSD1), ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1) and PHYTOALEXIN DEFICIENT 4 (PAD4) proteins are regulators of cell death (CD) in response to abiotic and biotic stresses. Hormones, such as salicylic acid (SA), and reactive oxygen species, such as hydrogen peroxide (H2O2), are key signaling molecules involved in plant CD. The proposed mathematical models presented in this study suggest that LSD1, EDS1 and PAD4 together with SA and H2O2 are involved in the control of plant water use efficiency (WUE), vegetative growth and generative development. The analysis of Arabidopsis wild‐type and single mutants lsd1, eds1, and pad4, as well as double mutants eds1/lsd1 and pad4/lsd1, demonstrated the strong conditional correlation between SA/H2O2 and WUE that is dependent on LSD1, EDS1 and PAD4 proteins. Moreover, we found a strong correlation between the SA/H2O2 homeostasis of 4‐week‐old Arabidopsis leaves and a total seed yield of 9‐week‐old plants. Altogether, our results prove that SA and H2O2 are conditionally regulated by LSD1/EDS/PAD4 to govern WUE, biomass accumulation and seed yield. Conditional correlation and the proposed models presented in this study can be used as the starting points in the creation of a plant breeding algorithm that would allow to estimate the seed yield at the initial stage of plant growth, based on WUE, SA and H2O2 content.

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“…The expression level of FMO1 was shown to be elevated in lsd1 background previously and confirmed in the current study ( Supplementary Figure S1 ), which strengthens the demonstrated contribution of FMO1 to the LSD1-dependent cell death pathway ( Figure 5 ). LSD1 has been recently demonstrated as a transcriptional regulator [ 47 ]. Although the FMO1 promoter was not among LSD1-bound sequences [ 47 ], it is possible that LSD1 inhibits FMO1 expression in an indirect manner, through another transcription regulator.…”

Section: Discussionmentioning

confidence: 99%

“…LSD1 has been recently demonstrated as a transcriptional regulator [ 47 ]. Although the FMO1 promoter was not among LSD1-bound sequences [ 47 ], it is possible that LSD1 inhibits FMO1 expression in an indirect manner, through another transcription regulator.…”

Section: Discussionmentioning

confidence: 99%

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FMO1 Is Involved in Excess Light Stress-Induced Signal Transduction and Cell Death Signaling

Czarnocka

Fichman

Bernacki

et al. 2020

Cells

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Because of their sessile nature, plants evolved integrated defense and acclimation mechanisms to simultaneously cope with adverse biotic and abiotic conditions. Among these are systemic acquired resistance (SAR) and systemic acquired acclimation (SAA). Growing evidence suggests that SAR and SAA activate similar cellular mechanisms and employ common signaling pathways for the induction of acclimatory and defense responses. It is therefore possible to consider these processes together, rather than separately, as a common systemic acquired acclimation and resistance (SAAR) mechanism. Arabidopsis thaliana flavin-dependent monooxygenase 1 (FMO1) was previously described as a regulator of plant resistance in response to pathogens as an important component of SAR. In the current study, we investigated its role in SAA, induced by a partial exposure of Arabidopsis rosette to local excess light stress. We demonstrate here that FMO1 expression is induced in leaves directly exposed to excess light stress as well as in systemic leaves remaining in low light. We also show that FMO1 is required for the systemic induction of ASCORBATE PEROXIDASE 2 (APX2) and ZINC-FINGER OF ARABIDOPSIS 10 (ZAT10) expression and spread of the reactive oxygen species (ROS) systemic signal in response to a local application of excess light treatment. Additionally, our results demonstrate that FMO1 is involved in the regulation of excess light-triggered systemic cell death, which is under control of LESION SIMULATING DISEASE 1 (LSD1). Our study indicates therefore that FMO1 plays an important role in triggering SAA response, supporting the hypothesis that SAA and SAR are tightly connected and use the same signaling pathways.

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The dual role of LESION SIMULATING DISEASE 1 as a condition‐dependent scaffold protein and transcription regulator

Cited by 39 publications

References 104 publications

Electrical Signaling, Photosynthesis and Systemic Acquired Acclimation

Electrical Signaling, Photosynthesis and Systemic Acquired Acclimation

LSD1‐, EDS1‐ and PAD4‐dependent conditional correlation among salicylic acid, hydrogen peroxide, water use efficiency and seed yield in Arabidopsis thaliana

FMO1 Is Involved in Excess Light Stress-Induced Signal Transduction and Cell Death Signaling

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