The dual-hit metabolic modulator LDCA synergistically potentiates doxorubicin to selectively combat cancer-associated hallmarks

Saha, Sanjoy Kumar; Ghosh, Monisankar; Dutta, Sourav

doi:10.1039/c7ra08625c

Cited by 2 publications

(2 citation statements)

References 43 publications

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“…6,7 The combination of multiple drugs with various mechanisms could be an effective strategy that might exhibit a synergistic activity. [8][9][10][11][12][13] However, the proper delivery of the combined therapy has some limitations and a proper chemical combination is highly desired due to the various physiological barriers and enzymatic processes in the body.…”

Section: Introductionmentioning

confidence: 99%

Combretastatin A4-camptothecin micelles as combination therapy for effective anticancer activity

et al. 2019

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Section: Introductionmentioning

confidence: 99%

Combretastatin A4-camptothecin micelles as combination therapy for effective anticancer activity

et al. 2019

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“…However, a significant correlation was also observed in long term assays indicating that both tests are reliable markers to prove the functional impacts of metabolic reprogramming on in vitro studies and could be used interchangeably. Although the comparison of scratch test and clonogenic assay have not been reported for the impact of short and long term reduction of glucose with or without beta-hydroxybutyrate supplementation in ovarian stem-like cancer cells the similar findings were reported for other kinds of treatments in different cancers [ 14 - 16 ].…”

Section: Discussionmentioning

confidence: 55%

Evaluation of Impacts of Cellular Metabolism on the Migration of Ovarian Cancer Cells by Two in Vitro Assays: A Method Comparison Study

Ghahremani

Sabet

Salami

2020

GMJ

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Background: Alteration of metabolic pathways in cancer cells can intensely modulate their migration as an important step in invasion and metastasis. Ketogenic diet showed some contradictory results in cancer patients. In this study the impact of metabolic reprogramming of A2780CP as a model of ovarian cancer stem-like cells on cell migration by two in vitro methods: wound healing and soft agar colony-forming assays. Materials and Methods: short term and long term metabolic reprogramming were done by restriction of glucose to 250mg/L with or without enrichment with beta-hydroxybutyrate (5 milimolar) for 48 hours and 30 days, respectively. Wound healing assay was done and the wound ratio was calculated for 24 and 48 hours. Soft agar colony formation assay was also done in treated and control cells. For method comparison, ten biological replicates were analyzed in triplicate. Results: Migration of A2780CP ovarian cancer stem-like cells were significantly alleviated by long term glucose restriction but no significant changes were observed in short term study. Beta-hydroxybutyrate enrichment did not produce significant impacts on glucose restriction in short or long term studies. Conclusion: The results of colony formation in soft agar and wound or scratch healing assay were in good correlation and convergence which could be used interchangeably in the investigation of metabolic reprogramming in cancer cells. [GMJ.2020;9:e1831]

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The dual-hit metabolic modulator LDCA synergistically potentiates doxorubicin to selectively combat cancer-associated hallmarks

Abstract: Dual-hit metabolic modulator LDCA synergistically potentiates doxorubicin to counter melanoma progression.

Cited by 2 publications

References 43 publications

Combretastatin A4-camptothecin micelles as combination therapy for effective anticancer activity

Combretastatin A4-camptothecin micelles as combination therapy for effective anticancer activity

Evaluation of Impacts of Cellular Metabolism on the Migration of Ovarian Cancer Cells by Two in Vitro Assays: A Method Comparison Study

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