The dual function of ovo/shavenbaby in germline and epidermis differentiation is conserved between Drosophila melanogaster and the olive fruit fly Bactrocera oleae

Khila, Abderrahman; Haidani, Ahmed El; Víncent, Alaín; Payre, François; Koraichi, Saâd Ibnsouda

doi:10.1016/s0965-1748(03)00063-8

Cited by 19 publications

(18 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Contrasting with the large number of molecules that are involved in the establishment of the trichome pattern during development, all examined cases of naked dorsal morphology in different fly species correlate with the modification of svb expression (Sucena and Stern, 2000;Khila et al, 2003;Sucena et al, 2003). In each case of trichome loss, while all other patterning genes that have been analysed display expression profiles indistinguishable from those of "hairy" species, svb expression is restricted to the remaining epidermal cells that produce extensions in "naked" species (Sucena and Stern, 2000;Khila et al, 2003;Sucena et al, 2003). This shows that modification of svb epidermal expression has been repeatedly selected during evolution to generate novel trichome patterns.…”

Section: Morphogenesis Of Epidermal Cellsmentioning

confidence: 99%

Genetic control of epidermis differentiation in Drosophila.

Payre¹

2004

Int. J. Dev. Biol.

View full text Add to dashboard Cite

In arthropods, the animal body is isolated from the external environment by a protective exoskeleton called the cuticle. The cuticle of young larvae has certainly been the most scrutinized structure in Drosophila and genetic studies of the pattern of cuticular extensions has provided the main source of our comprehension of the control of embryonic development. However, the complex structure of the cuticle remains poorly understood and analysis of the underlying epidermis has started only recently. Here I review different aspects of epidermis differentiation with the aim of presenting an integrated view of the organisation of the Drosophila integument. Although profound differences in epidermis organisation are observed across species, accumulated results suggest that epidermis formation and differentiation might share an unsuspected number of homologies between Drosophila and vertebrates.

show abstract

Section: Morphogenesis Of Epidermal Cellsmentioning

confidence: 99%

Genetic control of epidermis differentiation in Drosophila.

Payre¹

2004

Int. J. Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…from ovo loci may also be conserved, as dual ovo promotThe ovo genes of Drosophila and mice encode C 2 H 2 ers and ORFs are found in the distantly related olive zinc-finger transcription factors (Mevel-Ninio et al fruit fly, Bactrocera oleae (Khila et al 2003(Khila et al ). 1991Garfinkel et al 1992) …”

Section: G Ermline Sex Determination Inmentioning

confidence: 99%

“…Although the ovo gene sequence of several other Drosophila species is available, noncoding regulatory region sequence is not included. To obtain these sequences from other species, the putative regulatory region of ovo (Ϫ1 kb from the start of exon 2, which is common to both ovo-A and ovo-B transcripts) was compared with blastn (Altschul et al 1990) (Khila et al 2003) was extracted from BOL535757, accession AJ535757, gi:27656719. VISTA sequence alignments were used to compare each species to D. melanogaster (Mayor et al 2000).…”

Section: Required For Germ Cell Andmentioning

confidence: 99%

“…Mapping cis-regulatory domains: To identify cis-regucritical for ovo regulation are present (Khila et al 2003 gaster homology is at the ovo-B transcription start site. The deletion series built from lacZ ⌬ap revealed that tested them in wild-type and sex-transformed flies (Figure 2).…”

Section: Required For Germ Cell Andmentioning

confidence: 99%

“…The region flanking the modules derived from two species fail to function (Ludwig et al 2000). It is therefore possible that function of the B. oleae ovo-B core promoter in a D. melanogaster encoding an OVO-A isoform from the ovo-B promoter, ovary (Khila et al 2003) is maintained using a slightly and in flies bearing various copy numbers of ovo ⌬ap , an different transcription factor solution.…”

Section: Required For Germ Cell Andmentioning

confidence: 99%

See 2 more Smart Citations

Core Promoter Sequences Contribute to ovo-B Regulation in the Drosophila melanogaster Germline

Bielińska¹,

Lü²,

Sturgill

et al. 2005

Genetics

View full text Add to dashboard Cite

Utilization of tightly linked ovo-A vs. ovo-B germline promoters results in the expression of OVO-A and OVO-B, C 2 H 2 transcription factors with different N -termini, and different effects on target gene transcription and on female germline development. We show that two sex-determination signals, the X chromosome number within the germ cells and a female soma, differentially regulate ovo-B and ovo-A. We have previously shown that OVO regulates ovarian tumor transcription by binding the transcription start site. We have explored the regulation of the ovo-B promoter using an extensive series of transgenic reporter gene constructs to delimit cis-regulatory sequences as assayed in wild-type and sex-transformed flies and flies with altered ovo dose. Minimum regulated expression of ovo-B requires a short region flanking the transcription start site, suggesting that the ovo-B core promoter bears regulatory information in addition to a "basal" activity. In support of this idea, the core promoter region binds distinct factors in ovary and testis extracts, but not in soma extracts, suggesting that regulatory complexes form at the start site. This idea is further supported by the evolutionarily conserved organization of OVO binding sites at or near the start sites of ovo loci in other flies.

show abstract

Identification of tarsal-less peptides from the silkworm Bombyx mori

Cao

Gong

et al. 2018

Appl Microbiol Biotechnol

View full text Add to dashboard Cite

The polycistronic and non-canonical gene tarsal-less (tal, known as pri) was reported to be required for embryonic and imaginal development in Drosophila; however, there are few reports of the tal gene in the silkworm Bombyx mori. Here, we cloned a tal-like (Bmtal) gene, and a sequence analysis showed that the Bmtal cDNA (1661 bp) contains five small open reading frames (smORFs) (A1, A2, A3, A4, and B) that encode short peptides of 11-12 (A1-A4) amino acid residues containing an LDPTG(E)L(Q)(V)Y motif that is conserved in Drosophila Tal, as well as a 32-amino-acid B peptide. Reverse transcription-quantitative polymerase chain reaction showed that the expression of the Bmtal gene was highest in the trachea, followed by the silk gland and Malpighian tubule, in day 3 fifth-instar larvae. Subcellular localization showed that BmTal localized in the nucleus. By regulating the expression of the full-length Bmtal gene and the functional smORFs of Bmtal, we showed that the expression levels of the Bmovo gene and genes related to the Notch, transforming growth factor-β, and Hippo signaling pathways changed with changes in BmTal peptide expression. A co-immunoprecipitation assay showed that BmTal interacts with polyubiquitin, which triggered degradation and/or processing of the 14-3-3 protein zeta. A comparative transcriptome analysis showed that 2843 (2045) genes were up- (down)-regulated after Bmtal gene expression was up-regulated. The up- (down)-regulated differentially expressed genes were enriched in 326 (278) gene ontology terms (P ≤ 0.05) and 54 (59) Kyoto Encyclopedia of Genes and Genomes pathways (P ≤ 0.05), and the results indicated that the BmTal peptides could function as mediators of hormone levels or the activities of multiple pathways, including the peroxisome proliferator-activated receptor, Hedgehog, mitogen-activated protein kinase, adipocytokine, and gonadotropin-releasing hormone signaling pathways, as well as the innate immune response. These results increase our understanding of the function and mechanism of BmTal at the genome-wide level.

show abstract

The dual function of ovo/shavenbaby in germline and epidermis differentiation is conserved between Drosophila melanogaster and the olive fruit fly Bactrocera oleae

Cited by 19 publications

References 45 publications

Genetic control of epidermis differentiation in Drosophila.

Genetic control of epidermis differentiation in Drosophila.

Core Promoter Sequences Contribute to ovo-B Regulation in the Drosophila melanogaster Germline

Identification of tarsal-less peptides from the silkworm Bombyx mori

Contact Info

Product

Resources

About