The dual expression of minor and major bcr/abl chimeric mRNA in blast crisis of chronic myelogenous leukemia

Successful treatment of lymphoid blastic crisis in chronic myelogenous leukemia with the additional bcr/abl transcript using imatinib-combined chemotherapy and high-dose chemotherapy with allogeneic bone marrow stem cell transplantation

“…Therefore there were limited previous reports, the molecular meaning, biological significance and prognosis of CML-BC with co-existence of major and minor BCR/ABL remain unclear. However, Tanaka et al [5] reported that minor BCR/ABL transcript was reported to be the relation of the proliferation of lymphoid cells and disease progression in vivo. Consistent with previous reports, our case also suggested that the acquisition of the minor BCR/ABL transcript may be associated with disease progression in CML and the lymphoid crisis of CML.…”

“…Among patients with CML blast crisis and chromosomal abnormalities, there were only 4 patients who had additional chromosomal abnormalities such as the presence of major and minor BCR/ABL transcripts associated with the progression of CML blast crisis (Table 2). Tanaka et al [5] reported that the acquisition of the minor BCR/ABL transcript may be related to disease progression and the lymphoid crisis of CML.…”

“…Although the major BCR/ABL protein is present in majority of CML patients (95%), the minor BCR/ABL protein is present in minority of patients with acute lymphoblastic leukemia (20%) [1][2][3][4]. The coexpression of major and minor BCR/ABL transcripts in patients with CML was rarely reported as an additional chromosomal abnormality related to progression of CML [5].…”

Analysis of mRNA transcripts in chronic myeloid leukemia patients

“…Only studies in which the type of mRNA was determined by tests with a sensitivity similar to that employed in the present study, i.e., two consecutive rounds of PCR or one round with the use of radioactive probes to detect the amplified fragments, were considered. Data from the following reports were used in our search for associations between mRNA type and clinical parameters: Yin et al (1995) and Shepherd et al (1995) for the Sokal index, 123 cases; Yin et al (1995) and Gaiger et al (1995), for age at diagnosis, 35 cases; Ponzetto et al (1990), Nakamura et al (1991), Shepherd et al (1995), Gaiger et al (1995), Yin et al (1995), and Tanaka et al (1996), for sex, 181 cases; Hooberman et al (1989), Morgan et al (1990), Ponzetto et al (1990), Nakamura et al(1991), Fioretos et al (1993) and Tanaka et al (1996) for cell lineage, 43 cases.…”

Biphenotypic Acute Leukemia withBCR-ABLmRNA Transcript b3a2 Type: A Case Report with Review of the Literature

“…CML 환자의 절단 위치 별 빈도는 b3a2, b2a2 및 b3a2/b2a2가 각각 51-65%, 28-43% 및 6-10% 정도이다 [16]. CML에서의 e1a2의 형태의 존재는 ALL로 의 전환과 연관이 있다고 보고하였다 [19]. 성인 ALL에서는 b3a2 15%, b2a2 15% 및 e1a2 70%로 minor BCR-ABL이 대부분을 차지하며, 불량한 예후인자로 알려져 있다 [5].…”