The Dual Effect of Copper and Gamma Irradiation on Chronic Wound Healing of Nanobioactive Glass

Ahmed, Manar M.; Abd-Allah, W. M.; Omar, Areg E.; Soliman, A. M.

doi:10.1007/s10904-020-01501-0

Cited by 12 publications

(3 citation statements)

References 41 publications

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“…Then, the suitable amounts of a series of reagents were added in the following sequence: TEP, Ca(NO 3 ) 2 •4H 2 O, and ZIF-8 nanoparticles, allowing 30 min for each reagent to react completely. The molar ratio of water/TEOS is fixed at 12/1, the ratio of H 2 O/Ethanol is 1/1, and the volume ratio of water/nitric acid is fixed at 6/1 [19]. To prevent particle aggregation, the mixture was then transferred into a standard ultrasonic bath operating at a frequency of 50-60 kHz, 100-200 W, and then, 2 M ammonia solution (a gelation catalyst) was dropped into the mixture under constant stirring.…”

Section: Preparation Of Nano Bioactive Glass (Bg)mentioning

confidence: 99%

“…The band at 1064 cm −1 refers to P-O antisymmetric stretching which could have overlapped with that of Si-O-Si asymmetric stretching, while symmetric stretching of Si-O is observed at wavenumber 797 cm −1 . The shoulder around 950 cm −1 could be related to Si-O bonds containing non-bridging oxygen (Si-O-NBO) [18,19,27]. Finally, 558 and 600 cm −1 are due to orthophosphate groups [24].…”

Section: Structural Analysismentioning

confidence: 99%

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Bioactive glass doped with zinc-based metal–organic frameworks (Zn/MOF) nanoparticles for antibiotic delivery applications

Ahmed,

Omar,

Zayed

et al. 2024

Appl. Phys. A

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Zn-MOF/bioactive glass nanoparticles were successfully prepared using quick–alkali-modified sol–gel and tested for gentamicin drug delivery. Samples of 0 and 0.8 mol% Zn MOF contents (BG and BG/Zn MOF, respectively) were characterized using XRD, FTIR, TEM, and SEM/EDX. In addition, zeta characteristics and surface area parameters were also evaluated. Moreover, the cell viability of the prepared samples was tested against the osteosarcoma MG-63 cell line to evaluate the ability of prepared samples for bone regeneration. In addition, the antimicrobial activity of glass samples with and without antibiotics was determined against different microorganisms. Finally, the samples were loaded with gentamicin drug, and drug release profile and kinetics were studied too. XRD and FTIR results confirmed the physicochemical properties of the prepared samples. TEM results showed that particles were in the nano-sized range in both samples; however, the presence of Zn MOF increased the dispersity of particles. Both samples were bioactive, as indicated by hydroxyapatite formation on their surfaces. Cytotoxicity estimation of prepared materials exhibited their safe and nontoxic nature. BG/Zn MOF sample demonstrated prolonged drug release and excellent antimicrobial activity in comparison to BG alone. Therefore, the present study provides promising preliminary results regarding the usage of BG/Zn MOF nanoparticles loaded with gentamicin as an effective approach for bone regeneration. Graphical Abstract

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Section: Preparation Of Nano Bioactive Glass (Bg)mentioning

confidence: 99%

Section: Structural Analysismentioning

confidence: 99%

Bioactive glass doped with zinc-based metal–organic frameworks (Zn/MOF) nanoparticles for antibiotic delivery applications

Ahmed,

Omar,

Zayed

et al. 2024

Appl. Phys. A

Self Cite

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“…The scratch assay method was used to measure the migration rates of BJ.1 cells [30]. In a 24-well plate, cell density of "2 × 10 5 cells" was seeded into each well, before it was incubated at 37°C and 5% CO2 with complete medium.…”

Section: Wound Healing Activity Of Different Seeds Oils Via Wound Scr...mentioning

confidence: 99%

Chemical Composition and Bioactivities of Egyptian Opuntia ficus–indica Seeds Oils Obtained by Conventional and Ultrasound-assisted Extraction Techniques

et al. 2023

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The main objective of the current work was to assess the suitability of ultrasound-assisted extraction (UAE) for the oil recovery from Opuntia ficus-indica (L.) Mill. (O. ficus indica) seeds as compared to conventional extraction technique; Soxhlet extraction (SE). In the present study, the recovery oil yield, the saponifiable and unsaponifiable lipids of seeds oils obtained by different extraction methods, were compared. In addition, determination of the wound healing and analgesic activities of the plant seed oil, in vitro and in vivo, were evaluated. UAE and SE methods recovered total oil yields of 2.15% and 2.01%; respectively. Study of fatty acids composition exposed that the predominant fatty acids were linoleic acid (75.2% and 84.9%), oleic acid (14.01% and 8.18%) and palmitic acid (8.91% and 5.71%) for UAE and SE, respectively. Moreover, the most abundant sterol was β-Sitosterol (73.41% and 72.12%) followed by campesterol (8.84% and 8.57%) for UAE and SE, respectively. UAE significantly improved bioactivities of the oil with a significant increase in wound healing rate (85.7%) and inhibition of abdominal writhing (71.0%) compared to those obtained for oil prepared by SE (73.3% and 28.1%, respectively). Conclusion: Compared to conventional extraction method SE, the application of the innovative technique UAE for oil extraction increased the obtained oil yield of O. ficus indica and enhanced the biological activities in-vitro as well as in-vivo.

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Bioactive Glasses as Biologically Active Materials for Healing of Skin Wounds

Mehrabi

Mesgar

Mohammadi

2022

Bioactive Glasses and Glass‐Ceramics

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The Dual Effect of Copper and Gamma Irradiation on Chronic Wound Healing of Nanobioactive Glass

Cited by 12 publications

References 41 publications

Bioactive glass doped with zinc-based metal–organic frameworks (Zn/MOF) nanoparticles for antibiotic delivery applications

Bioactive glass doped with zinc-based metal–organic frameworks (Zn/MOF) nanoparticles for antibiotic delivery applications

Chemical Composition and Bioactivities of Egyptian Opuntia ficus–indica Seeds Oils Obtained by Conventional and Ultrasound-assisted Extraction Techniques

Bioactive Glasses as Biologically Active Materials for Healing of Skin Wounds

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