The Dual Association between Lymphoma and Autoimmunity

Ehrenfeld, Michael; Abu-Shakra, Mahmoud; Buskila, Dan; Shoenfeld, Yehuda

doi:10.1006/bcmd.2001.0442

Cited by 83 publications

(67 citation statements)

References 49 publications

(36 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…But even if the prevalence of other autoimmune disorders is higher in the cohort of firstdegree relatives than in the general population, it is still low in absolute terms. Taken together with reported low-range risk increases for malignant lymphomas in these conditions (34), our results are unlikely to be explained by such confounding.…”

Section: Ekströ M Et Alsupporting

confidence: 72%

“…The highly elevated risk estimate during the first year of followup is most likely inflated by an initial selection of RA patients with incipient malignant lymphoma referred for hospitalization, and some degree of initial misclassification of malignant lymphomas as RA. Indeed, a wide range of autoimmune features may occur in the course of lymphomas (34). However, even if the first year was excluded from the analyses, the risk remained increased nearly 2-fold over a 2-decade period.…”

Section: Discussionmentioning

confidence: 99%

“…Since few risk factors for RA as well as for malignant lymphomas are established, confounding is difficult to evaluate. Autoimmune disorders are known to aggregate in families, and several of these disorders have been associated with increased risks of malignant lymphomas (34). But even if the prevalence of other autoimmune disorders is higher in the cohort of firstdegree relatives than in the general population, it is still low in absolute terms.…”

Section: Ekströ M Et Almentioning

confidence: 99%

“…Reports on the association between autoimmune disorders and risk of malignant lymphomas in the same individuals are abundant (5,7,11,34,40). However, very few studies have focused on possible familial links between autoimmunity and hematopoietic malignancies in adults.…”

Section: Ekströ M Et Almentioning

confidence: 99%

See 3 more Smart Citations

Risk of malignant lymphomas in patients with rheumatoid arthritis and in their first‐degree relatives

Ekström¹,

Hjalgrim²,

Brandt³

et al. 2003

Arthritis & Rheumatism

250

152

View full text Add to dashboard Cite

Objective. Patients with rheumatoid arthritis (RA) are at increased risk for malignant lymphomas. Both conditions display a familial aggregation, and there are reports of RA and malignant lymphomas occurring in the same families. This study was undertaken to determine the risk of malignant lymphomas in first-degree relatives of RA patients, in order to investigate whether the increased risk of malignant lymphomas in RA could be due to genetic or environmental risk factors common to both conditions, rather than being a consequence of the rheumatic disease.Methods. Using Swedish nationwide and population-based registers, we identified 76,527 patients hospitalized with RA in 1964-1999 and 70,290 firstdegree relatives of a subset of these patients. These subjects were followed up for more than 3 decades, and information on cancer occurrence was recorded.Results. Patients with RA had a significantly increased risk of malignant lymphomas (535 cases; standardized incidence ratio [SIR] 2.00, 95% confidence interval [95% CI] 1.83-2.17), which was apparent for up to 2 decades of followup. Among the first-degree relatives without RA, no increased risk of malignant lymphomas was found overall, although modest and nonsignificantly elevated risk estimates were observed in subgroups. With respect to childhood cancer (0-14 years of age), we observed an increased risk of Hodgkin's lymphoma (5 cases; SIR 3.18, 95% CI 1.03-7.42).Conclusion. Patients with RA are at a markedly, but possibly time-limited, increased risk for malignant lymphomas. There is little to suggest a prominent role for coinherited or common environmental risk factors in malignant lymphomas arising in the context of RA. Instead, lymphomas complicating RA appear to be a direct consequence of the inflammation or its treatment.

show abstract

Section: Ekströ M Et Alsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Ekströ M Et Almentioning

confidence: 99%

Section: Ekströ M Et Almentioning

confidence: 99%

See 2 more Smart Citations

Risk of malignant lymphomas in patients with rheumatoid arthritis and in their first‐degree relatives

Ekström¹,

Hjalgrim²,

Brandt³

et al. 2003

Arthritis & Rheumatism

250

152

View full text Add to dashboard Cite

show abstract

“…17 Multiple types of human lymphoproliferative/autoimmune disease have been associated with increased incidence of lymphomas (reviewed in Ehrenfeld et al 18 ), and HTLVI infection can lead to both autoimmune disease and lymphoma. 19 Therefore, the presence of autoimmune disease in Gadd45aÀ/À mice may be a contributing factor to lymphomagenesis in the presence of additional tumor-promoting stimuli.…”

Section: Discussionmentioning

confidence: 99%