The dry eye syndrome in patients treated for breast cancer and methods to correct it

Kovalevskaya, M. A.; Turovets, Yekaterina Konstantinovna

doi:10.17816/ov2014134-39

Cited by 5 publications

(2 citation statements)

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“…Keratomycosis is a vision-threatening corneal fungal infectious disease that occurs all over the world, and is associated with progressive keratolysis, perforation, scleral extension, and endophthalmitis [21]. Poor visual outcomes are correlated to delays in clinical diagnosis, the virulence of fungal organisms, and limitations in effective antifungal agents [10, 11]. Corneal trauma, the injudicious/unreasonable use of corticosteroids or immunosuppressants, immunodeficiency diseases such as diabetes and AIDS, and the overuse of contact lenses are the major risk factors for the development of fungal keratitis [22].…”

Section: Discussionmentioning

confidence: 99%

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Simultaneous dermatophytosis and keratomycosis caused by Trichophyton interdigitale infection: a case report and literature review

Zhang

Jiang

et al. 2019

BMC Infect Dis

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BackgroundDermatophytosis is a fungal infectious disease caused by dermatophytes, which produce protease and keratinase to digest keratin, leading to the colonization, invasion, and infection of the stratum corneum of the skin, hair shafts, and nails. Trichophyton interdigitale belongs to Trichophyton mentagrophytes complex, which is the common pathogen causing dermatophytosis. Fungal keratitis, also called keratomycosis, is an infectious disease of cornea.Case presentationHere, we report a case of simultaneous dermatophytosis and keratomycosis caused by Trichophyton interdigitale. A 67-year-old man presented with extensive erythema all over the body since 4 years ago, fungal infection of left eye for 2 years, and loss of vision in the eye. These symptoms had become aggravated in the last month. Dermatological examinations showed extensive erythematous plaques with clear borders and scales, scattered red papules with ulceration, and scabs throughout the body. Onychomycosis was observed on the nails of left hand, conjunctival infection with secretion and loss of vision were noted in left eye. Hyaline septate hyphae were observed under direct microscopic examination, fungal culture and internal transcribed spacer sequencing revealed T. interdigitale. Histopathological examination suggested infectious granuloma. A diagnosis of dermatophytosis and keratomycosis caused by T. interdigitale with loss of vision in left eye was made. The patient was treated with luliconazole cream (two applications per day) and itraconazole (100 mg, BID, PO). Complete clinical remission was achieved after 1 month. Subsequently, the patient underwent left eye enucleation in the ophthalmology department.ConclusionsIn the present study, we reported a case of simultaneous dermatophytosis and keratomycosis caused by T. interdigitale, and reviewed the literature on corneal infection caused by Trichophyton. A total of 10 articles with 45 patients were published between 1973 and 2018. The pathogen of 27 patient were identified to species level. There were T. schoenleinii (17), T. mentagrophytes (4), T. verrucosum (3), T. rubrum (1), T. erinacei (1), and T. interdigitale (1). Five patients had corneal trauma, one had contact lens use history. Direct microscopic examination, fungal culture, and analysis of physiological characteristics were the main methods of identification. Early diagnosis and prompt treatment may help improve the management and outcomes.

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Section: Discussionmentioning

confidence: 99%

“…Fungal keratitis, also called keratomycosis, is an infectious disease of the cornea. Low awareness and delayed diagnosis of this condition lead to complications that can result in permanent loss of vision, and even necessitate enucleation [10, 11].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous dermatophytosis and keratomycosis caused by Trichophyton interdigitale infection: a case report and literature review

Zhang

Jiang

et al. 2019

BMC Infect Dis

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Advances in the Field of Microbial Infection in the Cornea and the Role of Nanotechnology in Treating Keratitis

Al-Mashahedah

Kanwar

2018

Drug Delivery for the Retina and Posterior Segment Disease

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The sino-nasal warzone: transcriptomic and genomic studies on sino-nasal aspergillosis in dogs

Valdés

Ruijter

Torres

et al. 2020

npj Biofilms Microbiomes

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We previously showed that each dog with chronic non-invasive sino-nasal aspergillosis (SNA) was infected with a single genotype of Aspergillus fumigatus. Here, we studied the transcriptome of this fungal pathogen and the canine host within the biofilm resulting from the infection. We describe here transcriptomes resulting from natural infections in animal species with A. fumigatus. The host transcriptome showed high expression of IL-8 and alarmins, uncontrolled inflammatory reaction and dysregulation of the Th17 response. The fungal transcriptome showed in particular expression of genes involved in secondary metabolites and nutrient acquisition. Single-nucleotide polymorphism analysis of fungal isolates from the biofilms showed large genetic variability and changes related with adaptation to host environmental factors. This was accompanied with large phenotypic variability in in vitro stress assays, even between isolates from the same canine patient. Our analysis provides insights in genetic and phenotypic variability of Aspergillus fumigatus in biofilms of naturally infected dogs reflecting in-host adaptation. Absence of a Th17 response and dampening of the Th1 response contributes to the formation of a chronic sino-nasal warzone.

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The dry eye syndrome in patients treated for breast cancer and methods to correct it

Cited by 5 publications

References 4 publications

Simultaneous dermatophytosis and keratomycosis caused by Trichophyton interdigitale infection: a case report and literature review

Simultaneous dermatophytosis and keratomycosis caused by Trichophyton interdigitale infection: a case report and literature review

Advances in the Field of Microbial Infection in the Cornea and the Role of Nanotechnology in Treating Keratitis

The sino-nasal warzone: transcriptomic and genomic studies on sino-nasal aspergillosis in dogs

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