The DrosophilaSTIM1 orthologue, dSTIM, has roles in cell fate specification and tissue patterning

Eid, Jean-Pierre; Arias, Alfonso Martínez; Robertson, H. M.; Hime, Gary R.; Dziadek, Marie

doi:10.1186/1471-213x-8-104

Cited by 22 publications

(21 citation statements)

References 101 publications

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“…Whereas for the locus at 50 cM, there is a mounting indication that the causal mutation might be located within or near the NCAPG gene, the genetic background of the putative second QTL at position 55 cM remains open. Although peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PPARGC1A) and stromal interaction molecule 2 (STIM2) are candidate genes for fetal growth due to their function in energy metabolism and embryonic development (Puigserver and Spiegelman 2003;Eid et al 2008), our data do not convincingly support a causal role of either gene regarding genetic modulation of fetal growth. Further research is necessary to elucidate the background of the second QTL affecting fetal growth.…”

Section: Discussioncontrasting

confidence: 51%

Dissection of Genetic Factors Modulating Fetal Growth in Cattle Indicates a Substantial Role of the Non-SMC Condensin I Complex, Subunit G (NCAPG) Gene

Eberlein¹,

Takasuga

Setoguchi³

et al. 2009

Genetics

144

161

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The increasing evidence of fetal developmental effects on postnatal life, the still unknown fetal growth mechanisms impairing offspring generated by somatic nuclear transfer techniques, and the impact on stillbirth and dystocia in conventional reproduction have generated increasing attention toward mammalian fetal growth. We identified a highly significant quantitative trait locus (QTL) affecting fetal growth on bovine chromosome 6 in a specific resource population, which was set up by consistent use of embryo transfer and foster mothers and, thus, enabled dissection of fetal-specific genetic components of fetal growth. Merging our data with results from other cattle populations differing in historical and geographical origin and with comparative data from human whole-genome association mapping suggests that a nonsynonymous polymorphism in the non-SMC condensin I complex, subunit G (NCAPG) gene, NCAPG c.1326T.G, is the potential cause of the identified QTL resulting in divergent bovine fetal growth. NCAPG gene expression data in fetal placentomes with different NCAPG c.1326T.G genotypes, which are in line with recent results about differential NCAPG expression in placentomes from studies on assisted reproduction techniques, indicate that the NCAPG locus may give valuable information on the specific mechanisms regulating fetal growth in mammals.

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Section: Discussioncontrasting

confidence: 51%

Dissection of Genetic Factors Modulating Fetal Growth in Cattle Indicates a Substantial Role of the Non-SMC Condensin I Complex, Subunit G (NCAPG) Gene

Eberlein¹,

Takasuga

Setoguchi³

et al. 2009

Genetics

144

161

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“…This induces apoptosis and reduces cell-cell adhesion (Mekahli et al, 2011). Smaller, blistered wings with thicker veins have been reported when SERCA, Stim or Orai is inhibited (Balaji et al, 2017;Eid et al, 2008;Restrepo and Basler, 2016). We confirmed that knocking down SERCA, Stim, and Orai led to smaller, blistered wings when driven by nub ( Fig.…”

Section: Oscillatory Ca 2+ Signal Exhibits Four Categories Of Ca 2+ Asupporting

confidence: 81%

“…Destabilizing the homeostatic concentrations of Ca 2+ in the ER and the cytoplasm influences Ca 2+ signaling differently than disrupting transient phenomena such as Ca 2+ release. SOC channels have been implicated in the control of growth and patterning in wing disc development (Eid et al, 2008;Richard and Hoch, 2015). Interestingly, knockdown of SOC channel components did not strongly impact ICT frequency.…”

Section: Discussionmentioning

confidence: 98%

In vivo relevance of intercellular calcium signaling inDrosophilawing development

Brodskiy

Huizar

et al. 2017

Preprint

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Recently, organ-scale intercellular Ca 2+ transients (ICTs) were reported in the Drosophila wing disc. However, the functional in vivo significance of ICTs remains largely unknown. Here we demonstrate the in vivo relevance of intercellular Ca 2+ signaling and its impact on wing development. We report that Ca 2+ signaling in vivo decreases as wing discs mature. Ca 2+ signaling ex vivo responds to fly extract in a dose-dependent manner. This suggests ICTs occur in vivo due to chemical stimulus that varies in concentration during development. RNAi mediated inhibition of genes required for ICTs results in defects in the size, shape, and vein patterning of adult wings. It also leads to reduction or elimination of in vivo Ca 2+ transients. Further, perturbations to the extracellular matrix along the basal side of the wing disc stimulates intercellular Ca 2+ waves. This is the first identified chemically defined, non-wounding stimulus of ICTs. Together, these results point toward specific in vivo functions of intercellular Ca 2+ signaling to mediate mechanical stress dissipation and ensure robust patterning during development.

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“…Stim1, which couples ER-PM Ca 2+ flux in mammals, is also highly conserved in flies and is essential for proper larval development and mechano-sensory bristle differentiation. 32,33 The yeast enoyl-reductase Tsc13 that localizes to ER-vacuole NVJs in yeast is conserved in flies as Sc2, whose loss is embryonic lethal. Mutant Sc2 alleles have also been shown to exacerbate fly models of spinocerebellar ataxia.…”

Section: Organelle Contact Site Proteins In Drosophila mentioning

confidence: 99%

Inter-organelle ER-endolysosomal contact sites in metabolism and disease across evolution

Hariri

Ugrankar

Liu

2016

Communicative & Integrative Biology

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Since their initial observation, contact sites formed between different organelles have transitioned from ignored curiosities to recognized centers for the exchange of metabolites and lipids. Contact formed between the ER and endomembrane system (eg. the plasma membrane, endosomes, and lysosomes) is of particular biomedical interest, as it governs aspects of lipid metabolism, organelle identity, and cell signaling. Here, we review the field of ER-endolysosomal communication from the perspective of three model systems: budding yeast, the fruit fly D. melanogaster, and mammals. From this broad perspective, inter-organelle communication displays a consistent role in metabolic regulation that was differentially tuned during the development of complex metazoan life. We also examine the current state of understanding of lipid exchange between organelles, and discuss molecular mechanisms by which this occurs.

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The DrosophilaSTIM1 orthologue, dSTIM, has roles in cell fate specification and tissue patterning

Cited by 22 publications

References 101 publications

Dissection of Genetic Factors Modulating Fetal Growth in Cattle Indicates a Substantial Role of the Non-SMC Condensin I Complex, Subunit G (NCAPG) Gene

Dissection of Genetic Factors Modulating Fetal Growth in Cattle Indicates a Substantial Role of the Non-SMC Condensin I Complex, Subunit G (NCAPG) Gene

In vivo relevance of intercellular calcium signaling inDrosophilawing development

Inter-organelle ER-endolysosomal contact sites in metabolism and disease across evolution

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