The Drosophila TNF Eiger Is an Adipokine that Acts on Insulin-Producing Cells to Mediate Nutrient Response

Agrawal, Neha; Delanoue, Rénald; Mauri, Alessandra; Basco, Davide; Pasco, Matthieu Y.; Thorens, Bernard; Léopold, Pierre

doi:10.1016/j.cmet.2016.03.003

Cited by 177 publications

(202 citation statements)

References 57 publications

Supporting

Mentioning

194

Contrasting

Order By: Relevance

“…It is made available under a The copyright holder for this preprint (which was not . http://dx.doi.org/10.1101/253542 doi: bioRxiv preprint first posted online Jan. 24, 2018; Our findings that IMD specifically affects insulin activity collaborate reports that the Drosophila TNFα homolog, Eiger, regulates production of insulin peptides in the brain (Agrawal et al, 2016), and that the FOXO homolog, Forkhead, regulates intestinal metabolism, and survival after infection in adult Drosophila (Bolukbasi et al, 2017). In addition, several studies identified interaction points between immune and insulin responses in the fly.…”

Section: Discussionsupporting

confidence: 62%

The Immune Deficiency Pathway Regulates Metabolic Homeostasis inDrosophila

Davoodi

Galenza

Panteluk

et al. 2018

Preprint

View full text Add to dashboard Cite

Immune and metabolic pathways collectively contribute to the containment of microbial invaders, and persistent activation of immune responses contribute to the development of severe metabolic disorders.To determine how a prolonged immune response impacts metabolism, we induced a constitutive inflammatory response in the Drosophila fat body, a key regulator of humoral immunity and metabolic homeostasis. We found that persistent immune activity replicated key features of a suppressed insulin pathway -delayed development, depleted fat reserves, and hyperglycemia. These observations led us to ask if the inhibition of insulin signaling improves host survival after infection. To test this, we challenged insulin pathway mutants with lethal doses of the enteric pathogen, Vibrio cholerae. We found that loss-of-function mutations in the insulin pathway extended viability and lowered bacterial loads, while gain-of-function mutations diminished viability and elevated bacterial loads. Combined, our results support a role for immune regulation of the insulin pathway in the survival of microbial challenges.

show abstract

Section: Discussionsupporting

confidence: 62%

The Immune Deficiency Pathway Regulates Metabolic Homeostasis inDrosophila

Davoodi

Galenza

Panteluk

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…In larvae, low protein diet induces Egr secretion from FBs into the hemolymph through inhibition of TOR (target of rapamycin) and induction of TNFα-converting enzyme (TACE), which cleaves Egr from the membrane (1). Egr binds to IPCs through the Grindelwald (Grnd) receptor, which acts through the Jun N-terminal kinase (JNK) pathway to inhibit Dilp2/5 mRNA expression and larval growth (1). In addition, under high sugar diet, Grnd signaling in FBs induces insulin resistance.…”

Section: Drosophila As a Model System To Dissect Interorgan Communicamentioning

confidence: 99%

Interorgan Communication Pathways in Physiology: Focus on Drosophila

2016

View full text Add to dashboard Cite

Studies in mammals and Drosophila have demonstrated the existence and significance of secreted factors involved in communication between distal organs. In this review, primarily focusing on Drosophila, we examine the known interorgan communication factors and their functions, physiological inducers, and integration in regulating physiology. Moreover, we describe how organ-sensing screens in Drosophila can systematically identify novel conserved interorgan communication factors. Finally, we discuss how interorgan communication enabled and evolved as a result of specialization of organs. Together, we anticipate that future studies will establish a model for metazoan interorgan communication network (ICN) and how it is deregulated in disease.

show abstract

“…Second, other signals from the brain and fat body are also associated with this biological process. For example, Agrawal et al argued that TNF-α converting enzyme (TACE)-mediated Eiger (Egr) secretion from the fat body contributes to organismal growth through Grindelwald (Grnd) activity in the brain in response to a normal protein diet (Agrawal et al, 2016). …”

Section: Links Between Larval Organsmentioning

confidence: 99%

Organ-to-Organ Communication: A Drosophila Gastrointestinal Tract Perspective

Liu

Jin

2017

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

The long-term maintenance of an organism's homeostasis and health relies on the accurate regulation of organ-organ communication. Recently, there has been growing interest in using the Drosophila gastrointestinal tract to elucidate the regulatory programs that underlie the complex interactions between organs. Data obtained in this field have dramatically improved our understanding of how organ-organ communication contributes to the regulation of various aspects of the intestine, including its metabolic and physiological status. However, although research uncovering regulatory programs associated with interorgan communication has provided key insights, the underlying mechanisms have not been extensively explored. In this review, we highlight recent findings describing gut-neighbor and neighbor-neighbor communication models in adults and larvae, respectively, with a special focus on how a range of critical strategies concerning continuous interorgan communication and adjustment can be used to manipulate different aspects of biological processes. Given the high degree of similarity between the Drosophila and mammalian intestinal epithelia, it can be anticipated that further analyses of the Drosophila gastrointestinal tract will facilitate the discovery of similar mechanisms underlying organ-organ communication in other mammalian organs, such as the human intestine.

show abstract

The Drosophila TNF Eiger Is an Adipokine that Acts on Insulin-Producing Cells to Mediate Nutrient Response

Cited by 177 publications

References 57 publications

The Immune Deficiency Pathway Regulates Metabolic Homeostasis inDrosophila

The Immune Deficiency Pathway Regulates Metabolic Homeostasis inDrosophila

Interorgan Communication Pathways in Physiology: Focus on Drosophila

Organ-to-Organ Communication: A Drosophila Gastrointestinal Tract Perspective

Contact Info

Product

Resources

About