The Drosophila Split Gal4 System for Neural Circuit Mapping

Luan, Haojiang; Diao, Feiyang; Scott, Robert L.; White, Benjamin H.

doi:10.3389/fncir.2020.603397

Cited by 53 publications

(46 citation statements)

References 153 publications

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“…Meanwhile, the cellular diversity of the Drosophila visual system has been rigorously determined by taking advantage of the powerful genetic tools as well as the smaller brain size that allows for the completion of a detailed EM-level connectome (Venken et al 2011;Takemura et al 2013;Zheng et al 2018;Scheffer et al 2020). Through multiple systematic screening studies, tools are available for robust cell type-specific genetic manipulation at multiple developmental stages (Nern et al 2015;Luan et al 2020), making the fly an ideal model system to study how individual cell types participate in the correlation of spontaneous activity.…”

Section: Using An Invertebrate Model To Study Correlated Spontaneous ...mentioning

confidence: 99%

Building a circuit through correlated spontaneous neuronal activity in the developing vertebrate and invertebrate visual systems

2021

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During the development of the vertebrate nervous systems, genetic programs assemble an immature circuit that is subsequently refined by neuronal activity evoked by external stimuli. However, prior to sensory experience, the intrinsic property of the developing nervous system also triggers correlated network-level neuronal activity, with retinal waves in the developing vertebrate retina being the best documented example. Spontaneous activity has also been found in the visual system of Drosophila. Here, we compare the spontaneous activity of the developing visual system between mammalian and Drosophila and suggest that Drosophila is an emerging model for mechanistic and functional studies of correlated spontaneous activity.

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Section: Using An Invertebrate Model To Study Correlated Spontaneous ...mentioning

confidence: 99%

Building a circuit through correlated spontaneous neuronal activity in the developing vertebrate and invertebrate visual systems

2021

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“…Thus, it is most likely that the reduced Per function in a subset of LNds rather than that in one of the l-LNvs impairs LTM consolidation, and Per in the LNds is critical for the acute physiologic regulation of the consolidation of courtship LTM. In Drosophila courtship memory, MB neurons are critically involved in the consolidation and maintenance of LTM (Fitzsimons & Scott, 2011;Inami et al, 2020Inami et al, ,2021Luan et al, 2020;Sakai et al, 2013). Thus, LNds may modulate physiologic properties in MB neurons in a Per-dependent manner (Figure 6a).…”

Section: Discussionmentioning

confidence: 99%

Dorsal–lateral clock neurons modulate consolidation and maintenance of long‐term memory in Drosophila

2022

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In nature, animals acquire various memories throughout the day. A newly acquired memory is initially unstable and cannot be maintained for a long time. However, under certain conditions, it is consolidated into the brain and maintained as stable long-term memory (LTM). Because of the availability of genetic tools to modify gene expression and neural function, the fruitfly Drosophila melanogaster is an excellent model to elucidate the molecular and cellular mechanisms of learning and memory. One of the behavioral assays to measure Drosophila memory, courtship conditioning, has been used to investigate molecular mechanisms of Drosophila LTM (Fitzsimons &

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“…Importantly, most of these lines are available from public repositories. In particular, there are a plethora of GAL4 lines for different brain cell types ( Pfeiffer et al, 2008 ; Jenett et al, 2012 ), allowing studies of very specific neuronal or glial sub-populations (see Doherty et al, 2009 ; Luan et al, 2020 ).…”

Section: Drosophila As a Model Systemmentioning

confidence: 99%

Mitochondria Dysfunction in Frontotemporal Dementia/Amyotrophic Lateral Sclerosis: Lessons From Drosophila Models

2021

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Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders characterized by declining motor and cognitive functions. Even though these diseases present with distinct sets of symptoms, FTD and ALS are two extremes of the same disease spectrum, as they show considerable overlap in genetic, clinical and neuropathological features. Among these overlapping features, mitochondrial dysfunction is associated with both FTD and ALS. Recent studies have shown that cells derived from patients’ induced pluripotent stem cells (iPSC)s display mitochondrial abnormalities, and similar abnormalities have been observed in a number of animal disease models. Drosophila models have been widely used to study FTD and ALS because of their rapid generation time and extensive set of genetic tools. A wide array of fly models have been developed to elucidate the molecular mechanisms of toxicity for mutations associated with FTD/ALS. Fly models have been often instrumental in understanding the role of disease associated mutations in mitochondria biology. In this review, we discuss how mutations associated with FTD/ALS disrupt mitochondrial function, and we review how the use of Drosophila models has been pivotal to our current knowledge in this field.

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The Drosophila Split Gal4 System for Neural Circuit Mapping

Cited by 53 publications

References 153 publications

Building a circuit through correlated spontaneous neuronal activity in the developing vertebrate and invertebrate visual systems

Building a circuit through correlated spontaneous neuronal activity in the developing vertebrate and invertebrate visual systems

Dorsal–lateral clock neurons modulate consolidation and maintenance of long‐term memory in Drosophila

Mitochondria Dysfunction in Frontotemporal Dementia/Amyotrophic Lateral Sclerosis: Lessons From Drosophila Models

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