The Drosophila ninaE gene encodes an opsin

O'Tousa, Joseph E.; Baehr, Wolfgang; Martin, Richard L.; Hirsh, Jay; Pak, William L.; Applebury, Meredithe L.

doi:10.1016/0092-8674(85)90343-5

Cited by 515 publications

(322 citation statements)

References 57 publications

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“…The predominant Drosophila rhodopsin, Rh1, encoded by the ninaE (neither inactivation nor afterpotential E) gene is the only rhodopsin expressed in the R1-R6 photoreceptor cells [40,41]. The minor opsins expressed in the central R7 and R8 photoreceptor cells are coordinately expressed in nonoverlapping subsets of cells.…”

Section: Diversity Of Drosophila Rhodopsinsmentioning

confidence: 99%

“…The first mutations linked to retinal degeneration were in ninaE, which encode the major rhodopsin, Rh1 [40,41,207,208]. This observation turned out to have relevance to human retinal dystrophies, as mutations in human rhodopsin were shown subsequently to account for a large proportion of the cases of autosomal dominant retinitis pigmentosa disease (ADRP) [209][210][211][212][213].…”

Section: Retinal Degenerationmentioning

confidence: 99%

See 1 more Smart Citation

Phototransduction and retinal degeneration in Drosophila

Wang

Montell

2007

Pflugers Arch - Eur J Physiol

257

303

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Drosophila visual transduction is the fastest known G-protein-coupled signaling cascade and has therefore served as a genetically tractable animal model for characterizing rapid responses to sensory stimulation. Mutations in over 30 genes have been identified, which affect activation, adaptation, or termination of the photoresponse. Based on analyses of these genes, a model for phototransduction has emerged, which involves phosphoinoside signaling and culminates with opening of the TRP and TRPL cation channels. Many of the proteins that function in phototransduction are coupled to the PDZ containing scaffold protein INAD and form a supramolecular signaling complex, the signalplex. Arrestin, TRPL, and Gα q undergo dynamic light-dependent trafficking, and these movements function in long-term adaptation. Other proteins play important roles either in the formation or maturation of rhodopsin, or in regeneration of phosphatidylinositol 4,5-bisphosphate (PIP 2 ), which is required for the photoresponse. Mutation of nearly any gene that functions in the photoresponse results in retinal degeneration. The underlying bases of photoreceptor cell death are diverse and involve mechanisms such as excessive endocytosis of rhodopsin due to stable rhodopsin/arrestin complexes and abnormally low or high levels of Ca 2+ . Drosophila visual transduction appears to have particular relevance to the cascade in the intrinsically photosensitive retinal ganglion cells in mammals, as the photoresponse in these latter cells appears to operate through a remarkably similar mechanism.

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Section: Diversity Of Drosophila Rhodopsinsmentioning

confidence: 99%

Section: Retinal Degenerationmentioning

confidence: 99%

Phototransduction and retinal degeneration in Drosophila

Wang

Montell

2007

Pflugers Arch - Eur J Physiol

257

303

View full text Add to dashboard Cite

show abstract

“…In ninaE mutants, the defective gene results in a low amount of visual pigment resulting in a depressed PDA (Scavarda et al, 1983). Cloning of the ninaE gene demonstrated that its product is the opsin in R1-6 photoreceptor cells (O'Tousa et al, 1985).…”

Section: Photoreceptor Mutantsmentioning

confidence: 99%

Insect retinal pigments: Spectral characteristics and physiological functions

Stavenga

1995

Progress in Retinal and Eye Research

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“…The three colour pigment receptor molecules expressed in cones are proposed to be arranged in a similar way. Visual pigments of the fruit fly Drosophila photoreceptor cells, R1-R8, were shown to share sequence homology with mammalian rhodopsin [217,322]. Mammalian and Drosophila opsin genes are thus proposed to derive from a common ancestor.…”

Section: G-protein-coupled Receptorsmentioning

confidence: 99%