“…Previous studies have implicated Htt in a variety of biological processes, including neurogenesis (Ben M’Barek et al, 2013), mitotic spindle orientation (Godin et al, 2010), chromatin organization (Dietz et al, 2015; Seong et al, 2010), macroautophagy (Rui et al, 2015), iron import (Lumsden, Henshall, Dayan, Lardelli, & Richards, 2007) cargo transport (Gauthier et al, 2004; Trushina et al, 2004) and synaptic plasticity (Choi et al, 2014). Here we demonstrate that Drosophila dhtt −/− mutants display defects in axonal transport of cargos in vivo .…”