The Drosophila Female Aphrodisiac Pheromone Activates ppk23+ Sensory Neurons to Elicit Male Courtship Behavior

Toda, Hirofumi; Zhao, Xinghui; Dickson, Barry J.

doi:10.1016/j.celrep.2012.05.007

Cited by 146 publications

(184 citation statements)

References 56 publications

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“…Liu et al, 2003aLiu et al, ,b, 2012Lu et al, 2012;Starostina et al, 2012;Thistle et al, 2012;Toda et al, 2012;Zelle et al, 2013;Guo et al, 2014;Mast et al, 2014;Vijayan et al, 2014 Larval terminal organ…”

Section: Olfactory and Gustatory Chemoreceptors In Flies: Several Recmentioning

confidence: 99%

“…In addition, at least three members of the TRP channels, TRP1, Painless, and TRPL are expressed in bitter neurons in the labellum where they are involved in detection of aversive compounds (Al-Anzi et al, 2006;Kim et al, 2010;Zhang et al, 2013b). Also, several ppk channels are expressed in taste neurons where they are required for relevant taste modalities such as low-salt detection (Liu et al, 2003b) and intraspecific chemical communication in larvae (Mast et al, 2014), and water perception (Cameron et al, 2010) and chemical communication during courtship in adults Lu et al, 2012;Starostina et al, 2012;Thistle et al, 2012;Toda et al, 2012;Vijayan et al, 2014). Finally, DmXR, a receptor homologous to metabotropic glutamate receptors that has lost the ability to bind glutamate (Mitri et al, 2004), may also act as a taste receptor.…”

Section: Chemoreceptors and Gustatory Detectionmentioning

confidence: 99%

“…Leg Aphrodisiac for intraspecific males, female receptivity promotion Liu et al, 2012;Lu et al, 2012;Thistle et al, 2012;Toda et al, 2012;Vijayan et al, 2014 IR52c-IR52d…”

Section: Chemoreceptors Involved In Food Sources Searching and Food Cmentioning

confidence: 99%

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Chemicals and chemoreceptors: ecologically relevant signals driving behavior in Drosophila

2015

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Insects encounter a vast repertoire of chemicals in their natural environment, which can signal positive stimuli like the presence of a food source, a potential mate, or a suitable oviposition site as well as negative stimuli such as competitors, predators, or toxic substances reflecting danger. The presence of specialized chemoreceptors like taste and olfactory receptors allows animals to detect chemicals at short and long distances and accordingly, trigger proper behaviors toward these stimuli. Since the first description of olfactory and taste receptors in Drosophila melanogaster 15 years ago, our knowledge on the identity, properties, and function of specific chemoreceptors has increased exponentially. In the last years, multidisciplinary approaches combining genetic tools with electrophysiological techniques, behavioral recording, evolutionary analysis, and chemical ecology studies are shedding light on our understanding on the ecological relevance of specific chemoreceptors for the survival of Drosophila in their natural environment. In this review we discuss the current knowledge on chemoreceptors of both the olfactory and taste systems of the fruitfly. We focus on the relevance of particular receptors for the detection of ecologically relevant cues such as pheromones, food sources, and toxic compounds, and we comment on the behavioral changes that the detection of these chemicals induce in the fly. In particular, we give an updated outlook of the chemical communication displayed during one of the most important behaviors for fly survival, the courtship behavior. Finally, the ecological relevance of specific chemicals can vary depending on the niche occupied by the individual. In that regard, in this review we also highlight the contrast between adult and larval systems and we propose that these differences could reflect distinctive requirements depending on the change of ecological niche occupied by Drosophila along its life cycle.

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Section: Olfactory and Gustatory Chemoreceptors In Flies: Several Recmentioning

confidence: 99%

Section: Chemoreceptors and Gustatory Detectionmentioning

confidence: 99%

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Chemicals and chemoreceptors: ecologically relevant signals driving behavior in Drosophila

2015

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“…One limitation is that the tastant must be water soluble, as it is delivered in the recording electrode along with the electrolyte. This increases the difficulty of recording with hydrocarbon compounds, though use of a solvent like DMSO has made some recording with pheromones possible 4 . Alternative approaches are to use a sharpened tungsten electrode to perform the recordings from the socket base of the sensillum, or use a glass electrode to perform recordings from the side wall of the sensillum, in both of which the tastant is delivered independently of the recording electrode 26,27 .…”

Section: Discussionmentioning

confidence: 99%

“…Taste is also thought to play a role in mate selection, through the detection of pheromones [1][2][3][4][5] . These important and diverse functions have made the insect taste system a compelling target of investigation into how sensory systems translate environmental cues into relevant behavioral outputs.…”

Section: Introductionmentioning

confidence: 99%

Electrophysiological Recording From <em>Drosophila</em> Labellar Taste Sensilla

Delventhal

Kiely

Carlson

2014

JoVE

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The peripheral taste response of insects can be powerfully investigated with electrophysiological techniques. The method described here allows the researcher to measure gustatory responses directly and quantitatively, reflecting the sensory input that the insect nervous system receives from taste stimuli in its environment. This protocol outlines all key steps in performing this technique. The critical steps in assembling an electrophysiology rig, such as selection of necessary equipment and a suitable environment for recording, are delineated. We also describe how to prepare for recording by making appropriate reference and recording electrodes, and tastant solutions. We describe in detail the method used for preparing the insect by insertion of a glass reference electrode into the fly in order to immobilize the proboscis. We show traces of the electrical impulses fired by taste neurons in response to a sugar and a bitter compound. Aspects of the protocol are technically challenging and we include an extensive description of some common technical challenges that may be encountered, such as lack of signal or excessive noise in the system, and potential solutions. The technique has limitations, such as the inability to deliver temporally complex stimuli, observe background firing immediately prior to stimulus delivery, or use water-insoluble taste compounds conveniently. Despite these limitations, this technique (including minor variations referenced in the protocol) is a standard, broadly accepted procedure for recording Drosophila neuronal responses to taste compounds. Video LinkThe video component of this article can be found at

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Multisensory neural integration of chemical and mechanical signals

Sánchez-Alcañiz

Benton

2017

BioEssays

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Chemosensation and mechanosensation cover an enormous spectrum of processes by which animals use information from the environment to adapt their behavior. For pragmatic reasons, these sensory modalities are commonly investigated independently. Recent advances, however, have revealed numerous situations in which they function together to control animals' actions. Highlighting examples from diverse vertebrates and invertebrates, we first discuss sensory receptors and neurons that have dual roles in the detection of chemical and mechanical stimuli. Next we present cases where peripheral chemosensory and mechanosensory pathways are discrete but intimately packaged to permit coordinated reception of external cues. Finally, we consider how chemical and mechanical signals converge in central neural circuitry to enable multisensory integration. These insights demonstrate how investigation of the interplay between different sensory modalities is key to a more holistic and realistic understanding of sensory-guided behaviors.

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The Drosophila Female Aphrodisiac Pheromone Activates ppk23+ Sensory Neurons to Elicit Male Courtship Behavior

Cited by 146 publications

References 56 publications

Chemicals and chemoreceptors: ecologically relevant signals driving behavior in Drosophila

Chemicals and chemoreceptors: ecologically relevant signals driving behavior in Drosophila

Electrophysiological Recording From <em>Drosophila</em> Labellar Taste Sensilla

Multisensory neural integration of chemical and mechanical signals

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