The Drosophila clotting system and its messages for mammals

Theopold, Ulrich; Krautz, Robert; Dushay, Mitchell S.

doi:10.1016/j.dci.2013.03.014

Cited by 61 publications

(45 citation statements)

References 45 publications

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“…We show that IDGF3 is an integral part of the hemolymph clot and contributes to the protection against EPNs. The latter finding provides further support for the clot's function in immunity [38,39] . Notably, the mouse CLP member Ym1 is amongst the most strongly induced proteins upon nematode infections in mice [40] , and its function in the protection against nematodes was strongly suggested in recent studies of the 3 mouse CLP members [8] .…”

Section: Discussionsupporting

confidence: 50%

The Drosophila Chitinase-Like Protein IDGF3 Is Involved in Protection against Nematodes and in Wound Healing

et al. 2015

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required for the formation of hemolymph clots that seal wounds, and Idgf3 mutants display an extended developmental delay during wound healing. Altogether, our findings indicate that vertebrate and invertebrate CLP proteins function in analogous settings and have a broad impact on inflammatory reactions and infections. This opens the way to further genetic analysis of Drosophila IDGF3 and will help to elucidate the exact molecular context of CLP function.

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Section: Discussionsupporting

confidence: 50%

The Drosophila Chitinase-Like Protein IDGF3 Is Involved in Protection against Nematodes and in Wound Healing

et al. 2015

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“…Drosophila blood cell formation also gives rise to smaller fractions of invertebrate-specific cell types. Crystal cells, named for their crystalline inclusions of Prophenoloxidase, mediate melanization reactions in innate immunity and wound healing 21,26 . Lamellocytes have roles in the encapsulation of large immune targets and melanization, but emerge only in the larva and mainly upon immune challenge 2,21,23,27-29 .…”

Section: Overview Of Drosophila Hematopoietic Waves and The Ontogeny mentioning

confidence: 99%

Drosophila as a model for the two myeloid blood cell systems in vertebrates

Gold¹,

Brückner

2014

Experimental Hematology

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Fish, mice and men rely on two coexisting myeloid blood cell systems. One is sustained by hematopoietic progenitor cells, which reside in specialized microenvironments in hematopoietic organs and give rise to cells of the monocyte lineage. The other system corresponds to the independent lineage of self-renewing tissue macrophages, which colonize organs during embryonic development and are maintained during later life by proliferation in local tissue microenvironments. However, little is known about the nature of these microenvironments and their regulation. Moreover, many vertebrate tissues contain a mix of both tissue-resident and monocyte-derived macrophages, posing a challenge to the study of lineage-specific regulatory mechanisms and function. This review highlights how research in the simple model organism Drosophila melanogaster can address many of these outstanding questions in the field. Drawing parallels between hematopoiesis in Drosophila and vertebrates, we illustrate the evolutionary conservation of the two myeloid systems across animal phyla. Much like vertebrates, Drosophila possesses a lineage of self-renewing tissue-resident macrophages, as well as a ‘definitive’ lineage of macrophages that derive from hematopoiesis in the progenitor-based lymph gland. We summarize key findings from Drosophila hematopoiesis that illustrate how local microenvironments, systemic signals, immune challenges and nervous inputs regulate adaptive responses of tissue-resident macrophages and progenitor-based hematopoiesis to achieve optimal fitness of the animal.

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“…Expression of AMPs is controlled by the evolutionary conserved signaling pathways Toll and IMD (immune deficiency), which regulate the activity of transcription factors of the NF-κB family [5, 6]. Proteolytic cascades involving sequential activation of serine proteases participate in the activation of the Toll pathway, and in the clotting and melanization responses to wounding [7, 8]. Cellular responses involving both circulating and sessile hemocytes also participate in antimicrobial host defense in flies, in particular via phagocytosis of bacteria by macrophage-like plasmatocytes and encapsulation of parasitic wasp eggs in larvae by lamellocytes [9–11].…”

Section: Introductionmentioning

confidence: 99%

Innate and intrinsic antiviral immunity in Drosophila

Mussabekova

Daeffler

Imler

2017

Cell. Mol. Life Sci.

116

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The fruitfly Drosophila melanogaster has been a valuable model to investigate the genetic mechanisms of innate immunity. Initially focused on the resistance to bacteria and fungi, these studies have been extended to include antiviral immunity over the last decade. Like all living organisms, insects are continually exposed to viruses and have developed efficient defense mechanisms. We review here our current understanding on antiviral host-defense in fruit flies. A major antiviral defense in Drosophila is RNA interference, in particular the small interfering (si) RNA pathway. In addition, complex inducible responses and restriction factors contribute to the control of infections. Some of the genes involved in these pathways have been conserved through evolution, highlighting loci that may account for susceptibility to viral infections in humans. Other genes are not conserved and represent species-specific innovations.

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The Drosophila clotting system and its messages for mammals

Cited by 61 publications

References 45 publications

The <b><i>Drosophila</i></b> Chitinase-Like Protein IDGF3 Is Involved in Protection against Nematodes and in Wound Healing

The <b><i>Drosophila</i></b> Chitinase-Like Protein IDGF3 Is Involved in Protection against Nematodes and in Wound Healing

Drosophila as a model for the two myeloid blood cell systems in vertebrates

Innate and intrinsic antiviral immunity in Drosophila

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