In this study, we analyzed the temporal-spatial variations of the characteristics of land use change in central Asia over the past two decades. This was conducted using four indicators (change rate, equilibrium extent, dynamic index, and transfer direction) and a multi-scale correlation analysis method, which explained the impact of recent environmental transformations on land use changes. The results indicated that the integrated dynamic degree of land use increased by 2.2% from 1995 to 2015. The areas of cropland, water bodies, and artificial land increased, with rates of 1047 km 2 /a, 39 km 2 /a, and 129 km 2 /a, respectively. On the other hand, the areas of forest, grassland, and unused land decreased, with rates of 54 km 2 /a, 803 km 2 /a, and 359 km 2 /a, respectively. There were significant increases in cropland and water bodies from 1995 to 2005, while the amount of artificial land significantly increased from 2005 to 2015. The increased areas of cropland in Xinjiang were mainly converted from grassland and unused land from 1995 to 2015, while the artificial land increase was mainly a result of the conversion from cropland, grassland, and unused land. The area of cropland rapidly expanded in south Xinjiang, which has led to centroid position to move cropland in Xinjiang in a southwest direction. Economic development and the rapid growth of population size are the main factors responsible for the cropland increases in Xinjiang. Runoff variations have a key impact on cropland changes at the river basin scale, as seen in three typical river basins.In arid areas, the main land use type is unused land, whereas cropland is distributed in oasis regions, while forest land and grassland are mainly located in mountainous areas [15]. In arid and semi-arid regions, there is a consistent performance showed that when cropland increased, the forest and grassland decreased. This occurred in South Asian [16], Central Asian [17], and the Mongolian plateau [18]. The stability of land use structure is relatively fragile and water resources are the basis and key factor for the changes of land use structure in arid regions. When glaciers and snow melt water runoff increase [17], cultivated land will also increase [19]. In the middle and later periods of glacier melt, the river outflow will be reduced and when the amounts of available water cannot support the levels of water use required by croplands, this can be followed by the desertification of cropland, such as in the Shiyang River Basin [20]. At the same time, human activities have also driven land use changes [21,22] and this anthropogenic role will increase with economic development or technology. The impact of human activities on land use types is multifaceted.Therefore, it is important to study the impacts of climate change and human activities on land use changes in arid regions. In this study, we focused on temporal-spatial variations of land use under climate change, in addition to human activities in arid regions from 1995 to 2015, based on land use data, runoff, c...