The DRASIC Cation Channel Contributes to the Detection of Cutaneous Touch and Acid Stimuli in Mice

Abstract

In the article by Price et al. (Neuron 32, 1071-1083 [December 20, 2001]), the x axis for stimulus response functions shown in Figures 3A-3F were incorrectly labeled and should read 50, 100, 200, and 400 m instead of 5, 10, 20, 40 m, as indicated in the original article. This error does not alter any of the conclusions made in the manuscript.

Recent advances in understanding molecular mechanisms of primary afferent activation

“…Disrupting the mouse DRASIC gene increased the sensitivity of mechanoreceptors detecting light touch, but it reduced the sensitivity of a mechanoreceptor responding to noxious pinch and decreased the response of acid and noxious heat sensitive nociceptors. 8 The data support the view that DRASIC subunits participate in heteromultimeric channel complexes in sensory neurons. One way to directly identify mechanosensitive channels is to expression clone them after characterising them in primary cultures of sensory neurons…”

Acid-sensing ion channel 3 expressed in type B synoviocytes and chondrocytes modulates hyaluronan expression and release

“…Congenic ASIC3−/− and ASIC3+/+ mice on a C57Bl/6J background29 were bred at the University of Iowa Animal Care Facility. Male mice, 9–10 weeks of age, were used in these studies.…”

Visceral hypersensitivity in non-erosive reflux disease

“…Whilst little is known of their role in inflammation/nociception in the gastrointestinal tract, their importance is suggested from altered transgenic animal responses to mucosal acid exposure31 32 as well as a study demonstrating their upregulation with gastrointestinal inflammation 33. NGF and serotonin (both of which are increased in mucosal inflammation) stimulate ASIC3 transcription in peripheral sensory neurons by a direct interaction with the promoter region of the ASIC3 gene 34…”