The Draize Test and Modifications

Johnson, Amanda; Goodwin, Benjamin

doi:10.1159/000411605

Cited by 28 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Staff carefully inspected the skin at the sites of sensor insertions and used the Draize scale to grade skin irritation. 24 Sensors were inspected by the study staff and the sponsor to assess any sensor breakoff during use.…”

Section: Veriomentioning

confidence: 99%

Improved Accuracy of Continuous Glucose Monitoring Systems in Pediatric Patients with Diabetes Mellitus: Results from Two Studies

Laffel

2016

Diabetes Technology & Therapeutics

View full text Add to dashboard Cite

Objective: This study was designed to evaluate accuracy, performance, and safety of the Dexcom (San Diego, CA) G4Ò Platinum continuous glucose monitoring (CGM) system (G4P) compared with the Dexcom G4 Platinum with Software 505 algorithm (SW505) when used as adjunctive management to blood glucose (BG) monitoring over a 7-day period in youth, 2-17 years of age, with diabetes. Research Design and Methods: Youth wore either one or two sensors placed on the abdomen or upper buttocks for 7 days, calibrating the device twice daily with a uniform BG meter. Participants had one in-clinic session on Day 1, 4, or 7, during which fingerstick BG measurements (self-monitoring of blood glucose [SMBG]) were obtained every 30 -5 min for comparison with CGM, and in youth 6-17 years of age, reference YSI glucose measurements were obtained from arterialized venous blood collected every 15 -5 min for comparison with CGM. The sensor was removed by the participant/family after 7 days. Results: In comparison of 2,922 temporally paired points of CGM with the reference YSI measurement for G4P and 2,262 paired points for SW505, the mean absolute relative difference (MARD) was 17% for G4P versus 10% for SW505 (P < 0.0001). In comparison of 16,318 temporally paired points of CGM with SMBG for G4P and 4,264 paired points for SW505, MARD was 15% for G4P versus 13% for SW505 (P < 0.0001). Similarly, error grid analyses indicated superior performance with SW505 compared with G4P in comparison of CGM with YSI and CGM with SMBG results, with greater percentages of SW505 results falling within error grid Zone A or the combined Zones A plus B. There were no serious adverse events or device-related serious adverse events for either the G4P or the SW505, and there was no sensor breakoff. Conclusions: The updated algorithm offers substantial improvements in accuracy and performance in pediatric patients with diabetes. Use of CGM with improved performance has potential to increase glucose time in range and improve glycemic outcomes for youth.

show abstract

Section: Veriomentioning

confidence: 99%

Improved Accuracy of Continuous Glucose Monitoring Systems in Pediatric Patients with Diabetes Mellitus: Results from Two Studies

Laffel

2016

Diabetes Technology & Therapeutics

View full text Add to dashboard Cite

show abstract

“…Normal behaviour of guinea pigs includes walking, running, tunnelling, horizontal stretching, retreating to a shelter, foraging, gnawing, and leaping (Johnson 2006). They exhibit thigmotaxis, a tendency to remain close to walls.…”

Section: Housing Requirementsmentioning

confidence: 99%

“…Durable, non‐toxic plastic flooring is ideal. Floor area should be a minimum of 2500 cm2 for guinea pigs over 450 g with an additional 900 cm2 for each additional guinea pig weighing over 700 g (Johnson 2006). Pregnant sows should be given plenty of room to exercise to reduce the risk of pregnancy toxaemia.…”

Section: Housing Requirementsmentioning

confidence: 99%

Management of husbandry‐related problems in guinea pigs

Fawcett¹

2011

In Practice

View full text Add to dashboard Cite

Poor husbandry is a leading cause of morbidity and mortality in guinea pigs. Subtle signs of illness in guinea pigs are also easily overlooked by owners, which means that many guinea pigs are often presented to the veterinary surgeon in a critical condition. By this stage, treatment, no matter how aggressive, may be unrewarding. This article discusses the common conditions affecting pet guinea pigs and the role of husbandry and diet in the aetiology and prevention of these diseases. In addition, it highlights the importance of educating clients to ensure they seek veterinary attention as soon as possible if their guinea pigs display signs of illness.

show abstract

“…Subjects underwent physical examination and vital sign measurements (blood pressure, pulse, aural temperature) after sensor removal. The sensor explant sites were evaluated for edema and erythema using the Draize scoring system 17,18 approximately 5 min following removal of the two sensors. Follow-up assessments were conducted 3 to 7 days after the procedure, including an assessment of adverse event reporting, a review of concomitant medications, and an examination of the sensor explant sites.…”

Section: Safetymentioning

confidence: 99%