The downregulation of IL-18R defines bona fide kidney-resident CD8+ T cells

Liao, Wei; Liu, Yong; Ma, Chaoyu; Wang, Liwen; Guo, Li; Mishra, Shruti; Srinivasan, Saranya; Fan, Kenneth; Wu, Haijing; Li, Qianwen; Zhao, Ming; Liu, Xun; Demel, Erika L.; Zhang, Xin; Qiu, Yuanzheng; Lu, Qianjin; Zhang, Nu

doi:10.1016/j.isci.2020.101975

Cited by 11 publications

(18 citation statements)

References 51 publications

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“…The expression of CD103 was TGF-b-dependent. Consistent with the findings in acute infection-induced TRM (43,56,57), the induction of CD69 was reduced, but not completely abolished in Tgfbr2 -/cells. Importantly, the highly restricted distribution of CD69 + CD103 + OT-1 in B16-OVA-draining LN, but not in B16-draining LN demonstrated that CD69 + CD103 + cells were bona fide TRM cells without circulation.…”

Section: Tgf-b and Tumor Antigen Together Induce Trm Phenotype On Stem-like T Cells In Tdlnsupporting

confidence: 89%

“…It is well established that TGF-b provides an essential signal for TRM differentiation after acute infections (38)(39)(40)(41)(42)(43). Stem-like T cells largely reside inside secondary lymphoid organs without circulation during chronic LCMV (lymphocytic choriomeningitis virus) infection (35).…”

Section: Tgf-b and Tumor Antigen Together Induce Trm Phenotype On Stem-like T Cells In Tdlnmentioning

confidence: 99%

“…It is well known that TGF-b signaling to CD8 + T cells is essential for the differentiation and maintenance of TRM after acute infection (38)(39)(40)(41)(42)(43). When focusing on tumor immunity, TRMlike signature has often been positively associated with the capacity of TILs to control tumor (44)(45)(46)(47)(48)(49)(50)(51).…”

Section: Introductionmentioning

confidence: 99%

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TGF-β-dependent Lymphoid Tissue Residency of Stem-like T cells Limits the Response to Tumor Vaccine

Guo

Wang

et al. 2021

Preprint

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Stem-like CD8+ T cells represent the key subset responding to multiple tumor immunotherapies, including tumor vaccination. However, the signals that control the differentiation of stem-like T cells are not entirely known. Most previous investigations on stem-like T cells are focused on tumor infiltrating T cells (TIL). The behavior of stem-like T cells in other tissues remains to be elucidated. Tissue-resident memory T cells (TRM) are often defined as a non-circulating T cell population residing in non-lymphoid tissues. TILs carrying TRM features are associated with better tumor control. Here, we found that stem-like CD8+ T cells differentiated into TRMs in a TGF-β and tumor antigen dependent manner almost exclusively in tumor draining lymph node (TDLN). TDLN-resident stem-like T cells were negatively associated with the response to tumor vaccine. In other words, after tumor vaccine, TDLN stem-like T cells transiently lost TRM features, differentiated into migratory effectors and exerted tumor control.

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Section: Tgf-b and Tumor Antigen Together Induce Trm Phenotype On Stem-like T Cells In Tdlnsupporting

confidence: 89%

Section: Tgf-b and Tumor Antigen Together Induce Trm Phenotype On Stem-like T Cells In Tdlnmentioning

confidence: 99%

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TGF-β-dependent Lymphoid Tissue Residency of Stem-like T cells Limits the Response to Tumor Vaccine

Guo

Wang

et al. 2021

Preprint

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“…275In the kidney, local TGFβ promotes the formation of Trm through enhancing the entry of effector memory T cells (Tem) into the tissue,276 consistent with similar mechanisms acting in the intestinal epithelium and skin 270,277. Furthermore, downregulation of the IL18 receptor, promoted through TGFβ signaling appears to be an important step in establishing T cells with a cell surface marker profile consistent with residency (CD103 + and CD69 + ), and an upregulated transcriptional residency programme in the kidney 278. While in mice, TGFβ has been identified as a signal influencing the differentiation of kidney-resident Trm, the environmental signals controlling the retention and maintenance of transcriptional and epigenetic programming of these cells remains to be uncovered.…”

mentioning

confidence: 73%

Epigenetics and tissue immunity—Translating environmental cues into functional adaptations*

Tuong

Stewart

Guo

et al. 2021

Immunological Reviews

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Tissue immune responses require the coordinated activation of specialized cell types, both professional immune cells and organ structural cells, each with differing, but tightly regulated, transcriptional programmes that are switched on and off in response to pathogen or tissue damage signals. The precise immune functionality of these tissue populations is determined by the selection of genes they express, encoding proteins that differentially contribute to immune responses. Tissue immune cells encounter an array of organ-specific conditions

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“…T RM cells have been reported in several human tissues such as the pancreas, liver, intestine, skin, kidney, brain, lung, as well as lymph nodes, adipose tissues, and salivary glands. [16][17][18][19][20][21][22][23][24][25][26] Various studies reported a core transcriptional residency program of T RM cells characterized by high expression of adhesion and retention biomarkers as well as down-regulation of tissue egress ones (S1PR1, CCR7, CD62L). 23 27 Expression of CD103 and/or CD69 are considered bona fide markers of T RM cells.…”

Section: Introductionmentioning

confidence: 99%

Tissue-resident memory T cells in gastrointestinal cancer immunology and immunotherapy: ready for prime time?

Abdeljaoued

Arfa

Kroemer

et al. 2022

J Immunother Cancer

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Tissue-resident memory T (TRM) cells have emerged as immune sentinels that patrol the tissue microenvironment and orchestrate localized antitumor immunity in various solid cancers. Recent studies have revealed that TRM cells are key players in cancer immunosurveillance, and their involvement has been linked to favorable responses to immunotherapy as well as general better clinical outcome in cancer patients. In this review, we provide an overview of the major advances and recent findings regarding TRM cells phenotype, transcriptional and epigenetic regulation in cancer with a special focus on gastrointestinal tumors. Finally, we highlight the exciting clinical implication of TRM cells in these types of tumors.

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The downregulation of IL-18R defines bona fide kidney-resident CD8+ T cells

Cited by 11 publications

References 51 publications

TGF-β-dependent Lymphoid Tissue Residency of Stem-like T cells Limits the Response to Tumor Vaccine

TGF-β-dependent Lymphoid Tissue Residency of Stem-like T cells Limits the Response to Tumor Vaccine

Epigenetics and tissue immunity—Translating environmental cues into functional adaptations*

Tissue-resident memory T cells in gastrointestinal cancer immunology and immunotherapy: ready for prime time?

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