The double life of a chemotherapy drug: Immunomodulatory functions of gemcitabine in cancer
Alaina C. Larson,
Kenadie R. Doty,
Joyce C. Solheim
Abstract:Although the development of immunotherapies has been revolutionary in the treatment of several cancers, many cancer types remain unresponsive to immune‐based treatment and are largely managed by chemotherapy drugs. However, chemotherapeutics are not infallible and are frequently rendered ineffective as resistance develops from prolonged exposure. Recent investigations have indicated that some chemotherapy drugs have additional functions beyond their normative cytotoxic capacity and are in fact immune‐modifying… Show more
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